Search Results - "Minissale, Elena"

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity by Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., Kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Lu, Alvin Z., Molina, Jennifer R., Minissale, Elena, Swinger, Kerren K., Wigle, Tim J., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Niepel, Mario, Varsamis, Zacharenia A., Nayak, Sunaina P., Bamberg, Ellen, Mo, Jan-Rung, Church, W. David, Mady, Ahmed S.A., Song, Jeff, Utley, Luke, Rao, Patricia E., Mitchison, Timothy J., Kuntz, Kevin W., Richon, Victoria M., Keilhack, Heike

“…PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative…”
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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants by Schenkel, Laurie B, Molina, Jennifer R, Swinger, Kerren K, Abo, Ryan, Blackwell, Danielle J, Lu, Alvin Z, Cheung, Anne E, Church, W David, Kunii, Kaiko, Kuplast-Barr, Kristy G, Majer, Christina R, Minissale, Elena, Mo, Jan-Rung, Niepel, Mario, Reik, Christopher, Ren, Yue, Vasbinder, Melissa M, Wigle, Tim J, Richon, Victoria M, Keilhack, Heike, Kuntz, Kevin W

“…PARP14 has been implicated by genetic knockout studies to promote protumor macrophage polarization and suppress the antitumor inflammatory response due to its…”
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Abstract 1348: Targeted degradation of PARP14 Using a heterobifunctional small molecule by Wigle, Tim, Ren, Yue, Molina, Jennifer, Blackwell, Danielle, Schenkel, Laurie, Swinger, Kerren, Cheug, Anne, Abo, Ryan, Minissale, Elena, Lu, Alvin, Majer, Christina, Church, William, Dorsey, Bryan, Niepel, Mario, Perl, Nicholas, Kuplast-Barr, Kristy, McEachern, Kristen, Vasbinder, Melissa, Keilhack, Heike, Kuntz, Kevin

“…Abstract PARP14 is an interferon-stimulated gene that is overexpressed in multiple tumor types and has been shown to promote the pro-tumor M2 polarization of…”
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Abstract 1038: A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants by Schenkel, Laurie, Molina, Jennifer, Swinger, Kerren, Abo, Ryan, Blackwell, Danielle, Cheung, Anne, Church, William, Kuplast-Barr, Kristy, Lu, Alvin, Minissale, Elena, Niepel, Mario, Vasbinder, Melissa, Wigle, Tim, Richon, Victoria, Keilhack, Heike, Kuntz, Kevin

“…Abstract PARPs (poly-ADP-ribose polymerases) are a family of enzymes that regulate a wide variety of important cellular processes including cellular stress…”
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Abstract 48: RBN-2397: A potent and selective small molecule inhibitor of PARP7 that induces tumor-derived antitumor immunity dependent on CD8 T cells by Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., Kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Lu, Alvin Z., Molina, Jennifer R., Minissale, Elena, Swinger, Kerren K., Wigle, Tim J., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Niepel, Mario, Bamberg, Ellen, Mo, Jan-Rung, Church, David, Song, Jeff, Utley, Luke, Rao, Patricia E., Mitchison, Timothy J., Kuntz, Kevin W., Richon, Victoria M., Keilhack, Heike

“…Abstract Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in…”
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Abstract 2154: PARP7 inhibitor RBN-2397 increases tumoral IFN signaling leading to various tumor cell intrinsic effects and tumor regressions in mouse models by Molina, Jennifer R., Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Nayak, Sunaina P., Minissale, Elena, Swinger, Kerren K., Wigle, Tim J., Lu, Alvin Z., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Bamberg, Ellen, Niepel, Mario, Mo, Jan-Rung, Church, William D., Mady, Ahmed S., Song, Jeff, Varsamis, Zacharenia A., Utley, Luke, Rao, Patricia E., Mitchison, Timoty J., Kuntz, Kevin W., Richon, Victoria M., McEachern, Kristen, Keilhack, Heike

“…Abstract Targeting cytosolic nucleic acid sensing pathways to activate the Type I interferon (IFN) response is an emerging therapeutic strategy being explored…”
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