Search Results - "Miniotis, Maria Falck"

Digital holographic microscopy for non-invasive monitoring of cell cycle arrest in L929 cells by Falck Miniotis, Maria, Mukwaya, Anthonny, Gjörloff Wingren, Anette

“…Digital holographic microscopy (DHM) has emerged as a powerful non-invasive tool for cell analysis. It has the capacity to analyse multiple parameters…”
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The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells by Delgado-Goni, Teresa, Miniotis, Maria Falck, Wantuch, Slawomir, Parkes, Harold G, Marais, Richard, Workman, Paul, Leach, Martin O, Beloueche-Babari, Mounia

“…Understanding the impact of BRAF signaling inhibition in human melanoma on key disease mechanisms is important for developing biomarkers of therapeutic…”
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MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells by MINIOTIS, Maria Falck, ARUNAN, Vaitha, EYKYN, Thomas R, MARAIS, Richard, WORKMAN, Paul, LEACH, Martin O, BELOUECHE-BABARI, Mounia

“…The RAS/BRAF/MEK/ERK signaling pathway is a central driver in cancer with many BRAF and MEK inhibitors being evaluated in clinical trials. Identifying…”
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Induction of morphological changes in death-induced cancer cells monitored by holographic microscopy by El-Schich, Zahra, Mölder, Anna, Tassidis, Helena, Härkönen, Pirkko, Falck Miniotis, Maria, Gjörloff Wingren, Anette

“…We are using the label-free technique of holographic microscopy to analyze cellular parameters including cell number, confluence, cellular volume and area…”
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Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data by Hill, Deborah K, Orton, Matthew R, Mariotti, Erika, Boult, Jessica K R, Panek, Rafal, Jafar, Maysam, Parkes, Harold G, Jamin, Yann, Miniotis, Maria Falck, Al-Saffar, Nada M S, Beloueche-Babari, Mounia, Robinson, Simon P, Leach, Martin O, Chung, Yuen-Li, Eykyn, Thomas R

“…Real-time detection of the rates of metabolic flux, or exchange rates of endogenous enzymatic reactions, is now feasible in biological systems using Dynamic…”
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A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using 19F magnetic resonance spectroscopy by Mancini, Laura, Davies, Lawrence, Friedlos, Frank, Falck-Miniotis, Maria, Dzik-Jurasz, Andrzej S, Springer, Caroline J., Leach, Martin O., Payne, Geoffrey S.

“…Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour are…”
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Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation by Johansson, Veronica M., Miniotis, Maria Falck, Hegardt, Cecilia, Jönsson, Göran, Staaf, Johan, Berntsson, Pia S.H., Oredsson, Stina M., Alm, Kersti

“…Polyamine depletion causes S phase prolongation, and earlier studies indicate that the elongation step of DNA replication is affected. This led us to…”
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Abstract 5083: Inhibition of MEK1/2 signaling in human BRAF V600E melanoma cells reduces glucose uptake and lactate dehydrogenase activity resulting in a time-dependent decrease in lactate production by Miniotis, Maria Falck, Eykyn, Thomas R., Workman, Paul, Leach, Martin O., Beloueche-Babari, Mounia

“…Abstract Background: Oncogenic transformation is associated with changes in cell metabolism. The MEK1/2 activator BRAF is mutated in ∼70% of malignant…”
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Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarized .sup.13C Magnetic Resonance Spectroscopy Data by Hill, Deborah K, Orton, Matthew R, Mariotti, Erika, Boult, Jessica K. R, Panek, Rafal, Jafar, Maysam, Parkes, Harold G, Jamin, Yann, Miniotis, Maria Falck, Al-Saffar, Nada M. S, Beloueche-Babari, Mounia, Robinson, Simon P, Leach, Martin O, Chung, Yuen-Li, Eykyn, Thomas R

“…Real-time detection of the rates of metabolic flux, or exchange rates of endogenous enzymatic reactions, is now feasible in biological systems using Dynamic…”
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A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using 19 F magnetic resonance spectroscopy by Mancini, Laura, Davies, Lawrence, Friedlos, Frank, Falck‐Miniotis, Maria, Dzik‐Jurasz, Andrzej S, Springer, Caroline J., Leach, Martin O., Payne, Geoffrey S.

“…Abstract Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour…”
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