Search Results - "Minhas, Paras S"

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration by Joshi, Amit U., Minhas, Paras S., Liddelow, Shane A., Haileselassie, Bereketeab, Andreasson, Katrin I., Dorn, Gerald W., Mochly-Rosen, Daria

“…In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated neuroinflammation, thus increasing neuronal death. Here we show that…”
Get full text

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy by Haileselassie, Bereketeab, Joshi, Amit U, Minhas, Paras S, Mukherjee, Riddhita, Andreasson, Katrin I, Mochly-Rosen, Daria

“…Out of the myriad of complications associated with septic shock, septic-associated encephalopathy (SAE) carries a significant risk of morbidity and mortality…”
Get full text

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology by Joshi, Amit U, Van Wassenhove, Lauren D, Logas, Kelsey R, Minhas, Paras S, Andreasson, Katrin I, Weinberg, Kenneth I, Chen, Che-Hong, Mochly-Rosen, Daria

“…Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East Asians. Recent…”
Get full text

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation by Minhas, Paras S., Liu, Ling, Moon, Peter K., Joshi, Amit U., Dove, Christopher, Mhatre, Siddhita, Contrepois, Kevin, Wang, Qian, Lee, Brittany A., Coronado, Michael, Bernstein, Daniel, Snyder, Michael P., Migaud, Marie, Majeti, Ravindra, Mochly-Rosen, Daria, Rabinowitz, Joshua D., Andreasson, Katrin I.

“…Recent advances highlight a pivotal role for cellular metabolism in programming immune responses. Here, we demonstrate that cell-autonomous generation of…”
Get full text

Restoring metabolism of myeloid cells reverses cognitive decline in ageing by Minhas, Paras S., Latif-Hernandez, Amira, McReynolds, Melanie R., Durairaj, Aarooran S., Wang, Qian, Rubin, Amanda, Joshi, Amit U., He, Joy Q., Gauba, Esha, Liu, Ling, Wang, Congcong, Linde, Miles, Sugiura, Yuki, Moon, Peter K., Majeti, Ravi, Suematsu, Makoto, Mochly-Rosen, Daria, Weissman, Irving L., Longo, Frank M., Rabinowitz, Joshua D., Andreasson, Katrin I.

“…Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty…”
Get full text

Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity by Liu, Qingkun, Johnson, Emily M., Lam, Rachel K., Wang, Qian, Bo Ye, Hong, Wilson, Edward N., Minhas, Paras S., Liu, Ling, Swarovski, Michelle S., Tran, Stephanie, Wang, Jing, Mehta, Swapnil S., Yang, Xi, Rabinowitz, Joshua D., Yang, Samuel S., Shamloo, Mehrdad, Mueller, Christoph, James, Michelle L., Andreasson, Katrin I.

“…Stroke is a multiphasic process in which initial cerebral ischemia is followed by secondary injury from immune responses to ischemic brain components. Here we…”
Get full text

Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau by Wilson, Edward N, Swarovski, Michelle S, Linortner, Patricia, Shahid, Marian, Zuckerman, Abigail J, Wang, Qian, Channappa, Divya, Minhas, Paras S, Mhatre, Siddhita D, Plowey, Edward D, Quinn, Joseph F, Zabetian, Cyrus P, Tian, Lu, Longo, Frank M, Cholerton, Brenna, Montine, Thomas J, Poston, Kathleen L, Andreasson, Katrin I

“…Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease and affects 1% of the population above 60 years old. Although…”
Get full text

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies by Minhas, Paras S, Jones, Jeffrey R, Latif-Hernandez, Amira, Sugiura, Yuki, Durairaj, Aarooran S, Wang, Qian, Mhatre, Siddhita D, Uenaka, Takeshi, Crapser, Joshua, Conley, Travis, Ennerfelt, Hannah, Jung, Yoo Jin, Liu, Ling, Prasad, Praveena, Jenkins, Brenita C, Ay, Yeonglong Albert, Matrongolo, Matthew, Goodman, Ryan, Newmeyer, Traci, Heard, Kelly, Kang, Austin, Wilson, Edward N, Yang, Tao, Ullian, Erik M, Serrano, Geidy E, Beach, Thomas G, Wernig, Marius, Rabinowitz, Joshua D, Suematsu, Makoto, Longo, Frank M, McReynolds, Melanie R, Gage, Fred H, Andreasson, Katrin I

“…Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer's disease (AD), with recent proteomic studies highlighting disrupted glial metabolism…”
Get full text

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models by Wilson, Edward N., Wang, Congcong, Swarovski, Michelle S., Zera, Kristy A., Ennerfelt, Hannah E., Wang, Qian, Chaney, Aisling, Gauba, Esha, Ramos Benitez, Javier A., Le Guen, Yann, Minhas, Paras S., Panchal, Maharshi, Tan, Yuting J., Blacher, Eran, A. Iweka, Chinyere, Cropper, Haley, Jain, Poorva, Liu, Qingkun, Mehta, Swapnil S., Zuckerman, Abigail J., Xin, Matthew, Umans, Jacob, Huang, Jolie, Durairaj, Aarooran S., Serrano, Geidy E., Beach, Thomas G., Greicius, Michael D., James, Michelle L., Buckwalter, Marion S., McReynolds, Melanie R., Rabinowitz, Joshua D., Andreasson, Katrin I.

“…Human genetics implicate defective myeloid responses in the development of late-onset Alzheimer disease. A decline in peripheral and brain myeloid metabolism,…”
Get full text

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity‐dependent synaptic and microglial transcriptomic changes in a late‐stage Alzheimer's mouse model by Latif‐Hernandez, Amira, Yang, Tao, Butler, Robert R., Losada, Patricia Moran, Minhas, Paras S., White, Halle, Tran, Kevin C., Liu, Harry, Simmons, Danielle A., Langness, Vanessa, Andreasson, Katrin I., Wyss‐Coray, Tony, Longo, Frank M.

“…INTRODUCTION Tropomyosin related kinase B (TrkB) and C (TrkC) receptor signaling promotes synaptic plasticity and interacts with pathways affected by amyloid…”
Get full text

Author Correction: Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration by Joshi, Amit U., Minhas, Paras S., Liddelow, Shane A., Haileselassie, Bereketeab, Andreasson, Katrin I., Dorn, Gerald W., Mochly-Rosen, Daria

“…A Correction to this paper has been published: https://doi.org/10.1038/s41593-020-00774-5…”
Get full text

Passport to pathology: transforming the medical student pathology elective from a passive educational experience to an exciting, immersive clinical rotation by Minhas, Paras S., Enogieru, Imarhia E., Mitchell, Richard N., Mata, Douglas A.

“…[...]of the specialty that a student ultimately plans to pursue, all medical students are required to take clinical rotations including surgery, medicine,…”
Get full text

A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation by Li, Li, Conradson, Devon M., Bharat, Vinita, Kim, Min Joo, Hsieh, Chung-Han, Minhas, Paras S., Papakyrikos, Amanda M., Durairaj, Aarooran Sivakumaran, Ludlam, Anthony, Andreasson, Katrin I., Partridge, Linda, Cianfrocco, Michael A., Wang, Xinnan

“…Mitochondria are the main site for generating reactive oxygen species, which are key players in diverse biological processes. However, the molecular pathways…”
Get full text

Immersion medicine programme for secondary students by Minhas, Paras S, Kim, Nathan, Myers, Jayson, Caceres, Wendy, Martin, Marina, Singh, Baldeep

“…Summary Background Although the proportion of ethnicities representing under‐represented minorities in medicine (URM) in the general population has…”
Get full text

Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis by Ardanaz, Carlos G, de la Cruz, Aida, Minhas, Paras S, Hernández-Martín, Nira, Pozo, Miguel Ángel, Valdecantos, M Pilar, Valverde, Ángela M, Villa-Valverde, Palmira, Elizalde-Horcada, Marcos, Puerta, Elena, Ramírez, María J, Ortega, Jorge E, Urbiola, Ainhoa, Ederra, Cristina, Ariz, Mikel, Ortiz-de-Solórzano, Carlos, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, Karsenty, Gerard, Brüning, Jens C, Solas, Maite

“…Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity of the main astrocyte glucose…”
Get full text

Abstract B046: Irradiation of patient-derived high-grade gliomas reduces 5-ALA-induced fluorescence utility during re-resection by Minhas, Paras S., Durairaj, Aarooran, McReynolds, Melanie, Andreasson, Katrin I., Jung, YooJin, Rabinowitz, Joshua

“…High grade gliomas HGGs are among the most aggressive primary brain tumors, yielding a median survival time of less than 2 years and a 5-year survival of 2.5%…”
Get full text

Macrophage de novo NAD.sup.+ synthesis specifies immune function in aging and inflammation by Minhas, Paras S, Liu, Ling, Moon, Peter K, Joshi, Amit U, Dove, Christopher, Mhatre, Siddhita, Contrepois, Kevin

“…Recent advances highlight a pivotal role for cellular metabolism in programming immune responses. Here, we demonstrate that cell-autonomous generation of…”
Get full text

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer’s disease mouse models by Wilson, Edward N., Wang, Congcong, Swarovski, Michelle S., Zera, Kristy A., Ennerfelt, Hannah E., Wang, Qian, Chaney, Aisling, Gauba, Esha, Benitez, Javier A. Ramos, Le Guen, Yann, Minhas, Paras S., Panchal, Maharshi, Tan, Yuting J., Blacher, Eran, Iweka, Chinyere A., Cropper, Haley, Jain, Poorva, Liu, Qingkun, Mehta, Swapnil S., Zuckerman, Abigail J., Xin, Matthew, Umans, Jacob, Huang, Jolie, Durairaj, Aarooran S., Serrano, Geidy E., Beach, Thomas G., Greicius, Michael D., James, Michelle L., Buckwalter, Marion S., McReynolds, Melanie R., Rabinowitz, Joshua D., Andreasson, Katrin I.

“…Human genetics implicate defective myeloid responses in the development of late onset Alzheimer’s disease (AD). A decline in peripheral and brain myeloid…”
Get full text