Search Results - "Mingone, Christopher J"

Thiol oxidation inhibits nitric oxide-mediated pulmonary artery relaxation and guanylate cyclase stimulation by Mingone, Christopher J, Gupte, Sachin A, Ali, Noorjahan, Oeckler, Richard A, Wolin, Michael S

“…The mechanisms through which thiol oxidation and cellular redox influence the regulation of soluble guanylate cyclase (sGC) are poorly understood. This study…”
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Hypoxia enhances a cGMP-independent nitric oxide relaxing mechanism in pulmonary arteries by Mingone, Christopher J, Gupte, Sachin A, Iesaki, Takafumi, Wolin, Michael S

“…Nitric oxide (NO) donors generally relax vascular preparations through cGMP-mediated mechanisms. Relaxation of endothelium-denuded bovine pulmonary arteries…”
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Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes by Turkseven, Saadet, Kruger, Adam, Mingone, Christopher J, Kaminski, Pawel, Inaba, Muneo, Rodella, Luigi F, Ikehara, Susumu, Wolin, Michael S, Abraham, Nader G

“…Increased heme oxygenase (HO)-1 activity attenuates endothelial cell apoptosis and decreases superoxide anion (O2-) formation in experimental diabetes by…”
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Redox regulation of responses to hypoxia and NO-cGMP signaling in pulmonary vascular pathophysiology by Wolin, Michael S., Gupte, Sachin A., Mingone, Christopher J., Neo, Boon Hwa, Gao, Qun, Ahmad, Mansoor

“…Pulmonary vascular responses elicited by hypoxia and NO‐cGMP signaling are potentially influenced by ROS and redox mechanisms that change during the…”
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Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation by Mingone, Christopher J, Gupte, Sachin A, Chow, Joseph L, Ahmad, Mansoor, Abraham, Nader G, Wolin, Michael S

“…Protoporphyrin IX is an activator of soluble guanylate cyclase (sGC), but its role as an endogenous regulator of vascular function through cGMP has not been…”
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Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide by Mingone, Christopher J, Ahmad, Mansoor, Gupte, Sachin A, Chow, Joseph L, Wolin, Michael S

“…This study examines in endothelium-denuded bovine pulmonary arteries the effects of increasing heme oxygenase-1 (HO-1) activity on relaxation and soluble…”
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Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells by Abraham, Nader G, Quan, Shuo, Mieyal, Paul A, Yang, Liming, Burke-Wolin, Theresa, Mingone, Christopher J, Goodman, Alvin I, Nasjletti, Alberto, Wolin, Michael S

“…Carbon monoxide (CO) stimulates guanylate cyclase (GC) and increases guanosine 3',5'-cyclic monophosphate (cGMP) levels. We transfected rat-lung pulmonary…”
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Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP by Mingone, Christopher J, Gupte, Sachin A, Quan, Shuo, Abraham, Nader G, Wolin, Michael S

“…Heme is a co-factor required for the stimulation of soluble guanylate cyclase (sGC) by nitric oxide (NO) and carbon monoxide, and sGC activation by these…”
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Protoporphyrin IX Generation from ä‐Aminolevulinic Acid Elicits Pulmonary Artery Relaxation and Soluble Guanylate Cyclase Activation by Mingone, Christopher J., Gupte, Sachin A., Chow, Joseph L., Abraham, Nader G., Wolin, Michael S.

“…Protoporphyrin IX (PpIX) has been shown to be an activator of soluble guanylate cyclase (sGC), but, its role as an endogenous regulator of vascular function…”
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Augmented Glucose‐6‐Phosphate Dehydrogenase Activity in Diabetic Rats and Humans Regulates Vascular Function by Ahmad, Mansoor, Floyd, Beverly C, Mingone, Christopher J, Wolin, Michael S, Gupte, Sachin A

“…Glucose uptake and metabolism is altered in diabetes. In this study, we investigated whether glucose catabolism through the pentose phosphate pathway (PPP) is…”
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Mechanisms Regulating Nitric Oxide-mediated Vascular Relaxation through Soluble Guanylate Cyclase by Hypoxia, Thiol Redox and Heme Metabolism by Mingone, Christopher J

“…Soluble guanylate cyclase (sGC), a heme containing enzyme, is the major receptor for NO in the vascular smooth muscle and is responsible for the production of…”
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Influence of heme metabolism and redox regulation of sGC in the control of vascular function by Wolin, Michael S, Gupte, Sachin A, Ahmad, Mansoor, Mingone, Christopher J

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Nitric oxide-donor SNAP induces vasorelaxation of bovine pulmonary artery under hypoxia via a novel mechanism independent of cGMP by Mingone, Christopher J

“…It is well established that NO-donors like SNAP elicit relaxation of endothelium-removed bovine pulmonary arteries (BPA) through activation of a NO-cGMP…”
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