Search Results - "Ming, C. C."
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Laser frequency sweep linearization by iterative learning pre-distortion for FMCW LiDAR
Published in Optics express (01-04-2019)“…We report on a laser frequency sweep linearization method by iterative learning pre-distortion for frequency-modulated continuous-wave (FMCW) light detection…”
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A large-scale microelectromechanical-systems-based silicon photonics LiDAR
Published in Nature (London) (10-03-2022)“…Three-dimensional (3D) imaging sensors allow machines to perceive, map and interact with the surrounding world 1 . The size of light detection and ranging…”
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3
RNA-based fluorescent biosensors for live cell imaging of small molecules and RNAs
Published in Current opinion in biotechnology (01-06-2020)“…[Display omitted] •Palette of fluorogenic RNA-dye pairs now are available for biosensor engineering.•RNA-based fluorescent biosensors developed for molecular…”
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Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs
Published in Cell (09-05-2013)“…Tumor necrosis factor-α (TNF-α) is the most potent proinflammatory cytokine in mammals. The degradation of TNF-α mRNA is critical for restricting TNF-α…”
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5
Optoelectronic tweezers
Published in Nature photonics (01-06-2011)“…Using projected light patterns to form virtual electrodes on a photosensitive substrate, optoelectronic tweezers are able to grab and move micro- and nanoscale…”
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Pharmacokinetics‐Bridging Between Autoinjectors and Prefilled Syringes for Subcutaneous Injection: Case Examples Revealing a Knowledge Gap
Published in Clinical pharmacology and therapeutics (01-03-2024)“…Comparative pharmacokinetics (PK) studies have efficiently served as the bridge between autoinjectors and prefilled syringes given the underlying principles…”
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A survey of FDA Approved Monoclonal Antibodies and Fc-fusion Proteins for Manufacturing Changes and Comparability Assessment
Published in Pharmaceutical research (2024)“…Objective Manufacturing changes occur commonly throughout stages of biologics development and may result in product quality attribute changes. As changes in…”
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Subwavelength metal-optic semiconductor nanopatch lasers
Published in Optics express (26-04-2010)“…We report on near infrared semiconductor nanopatch lasers with subwavelength-scale physical dimensions (0.019 cubic wavelengths) and effective mode volumes…”
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Leveraging Clinical Pharmacology Data to Assess Biosimilarity and Interchangeability of Insulin Products
Published in Clinical pharmacology and therapeutics (01-04-2023)“…There is over a hundred years of clinical experience with insulin for the treatment of diabetes. The US Food and Drug Administration (FDA) approved the first…”
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PODTherm-GP: A Physics-based Data-Driven Approach for Effective Architecture-Level Thermal Simulation of Multi-Core CPUs
Published in IEEE transactions on computers (01-10-2023)“…A thermal simulation methodology derived from the proper orthogonal decomposition (POD) and the Galerkin projection (GP), hereafter referred to as PODTherm-GP,…”
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Additive manufacturing: technology, applications and research needs
Published in Frontiers of Mechanical Engineering (01-09-2013)“…Additive manufacturing (AM) technology has been researched and developed for more than 20 years. Rather than removing materials, AM processes make…”
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High-accuracy range-sensing system based on FMCW using low-cost VCSEL
Published in Optics express (02-04-2018)“…Long-range shape measurement with high accuracy is needed for precision manufacturing of large-scale parts such as turbines, compressors, and trains. We have…”
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13
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
Published in Cell reports (Cambridge) (30-05-2013)“…The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce…”
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14
Fast-Accurate Full-Chip Dynamic Thermal Simulation With Fine Resolution Enabled by a Learning Method
Published in IEEE transactions on computer-aided design of integrated circuits and systems (01-08-2023)“…The need for full-chip dynamic thermal simulation for effective runtime thermal management of multicore processors has been growing in recent years due to the…”
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Engineering and In Vivo Applications of Riboswitches
Published in Annual review of biochemistry (20-06-2017)“…Riboswitches are common gene regulatory units mostly found in bacteria that are capable of altering gene expression in response to a small molecule. These…”
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Hierarchical Design and Optimization of Silicon Photonics
Published in IEEE journal of selected topics in quantum electronics (01-03-2020)“…Silicon photonics is a rapidly maturing platform for optical communication and sensing. As systems leveraging silicon photonics have grown in size and…”
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Evaluating and Reporting the Immunogenicity Impacts for Biological Products—a Clinical Pharmacology Perspective
Published in The AAPS journal (01-03-2016)“…Immunogenicity assessment is important for biological products due to potential impacts of immunogenicity on safety and efficacy. We reviewed the prescribing…”
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18
Optical antenna enhanced spontaneous emission
Published in Proceedings of the National Academy of Sciences - PNAS (10-02-2015)“…Significance Since the invention of the laser over 50 y ago, stimulated emission has been stronger and far more important than spontaneous emission, the…”
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Soluble Prorenin Receptor Increases Blood Pressure in High Fat–Fed Male Mice
Published in Hypertension (Dallas, Tex. 1979) (01-10-2019)“…Obesity-related hypertension is a major public health concern. We recently demonstrated that plasma levels of the soluble form of the prorenin receptor (sPRR)…”
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Clinical Pharmacology Approaches to Support Approval of New Routes of Administration for Therapeutic Proteins
Published in Clinical pharmacology and therapeutics (01-03-2024)“…Intravenous or subcutaneous routes of administration (ROAs) are common dosing routes for therapeutic proteins. Eleven therapeutic proteins with approval for…”
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