Search Results - "Minetti, Conceição A.S.A."

Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions by Chen, Li, Balabanidou, Vassilia, Remeta, David P., Minetti, Conceição A.S.A., Portaliou, Athina G., Economou, Anastassios, Kalodimos, Charalampos G.

“…Protein-protein interactions mediate a vast number of cellular processes. Here, we present a regulatory mechanism in protein-protein interactions mediated by…”
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Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion by Chen, Li, Ai, Xuanjun, Portaliou, Athina G., Minetti, Conceicao A.S.A., Remeta, David P., Economou, Anastassios, Kalodimos, Charalampos G.

“…The targeting of type III secretion (TTS) proteins at the injectisome is an important process in bacterial virulence. Nevertheless, how the injectisome…”
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Impact of α-hydroxy-propanodeoxyguanine adducts on DNA duplex energetics: Opposite base modulation and implications for mutagenicity and genotoxicity by Minetti, Conceição A. S. A., Remeta, David P., Johnson, Francis, Iden, Charles R., Breslauer, Kenneth J.

“…Acrolein is an α,β‐unsaturated aldehyde that is a major environmental pollutant, as well as a product of cellular metabolism. DNA bases react with acrolein to…”
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continuous hyperchromicity assay to characterize the kinetics and thermodynamics of DNA lesion recognition and base excision by Minetti, Conceição A.S.A, Remeta, David P, Breslauer, Kenneth J

“…We report a continuous hyperchromicity assay (CHA) for monitoring and characterizing enzyme activities associated with DNA processing. We use this assay to…”
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Energetics of Lesion Recognition by a DNA Repair Protein: Thermodynamic Characterization of Formamidopyrimidine-glycosylase (Fpg) Interactions with Damaged DNA Duplexes by Minetti, Conceição A.S.A, Remeta, David P, Zharkov, Dmitry O, Eric Plum, G, Johnson, Francis, Grollman, Arthur P, Breslauer, Kenneth J

“…As part of an overall effort to map the energetic landscape of the base excision repair pathway, we report the first thermodynamic characterization of repair…”
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Magnesium Activates Microsecond Dynamics to Regulate Integrin-Collagen Recognition by Nunes, Ana Monica, Minetti, Conceição A.S.A., Remeta, David P., Baum, Jean

“…Integrin receptors bind collagen via metal-mediated interactions that are modulated by magnesium (Mg2+) levels in the extracellular matrix. Nuclear magnetic…”
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A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N‑Terminal Acetylation by Moriarty, Gina M, Minetti, Conceição A. S. A, Remeta, David P, Baum, Jean

“…α-Synuclein (αS) is an amyloidogenic intrinsically disordered protein implicated in Parkinson’s disease, for which copper-mediated pathways of…”
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Heat Shock Protein 90 kDa (Hsp90) Has a Second Functional Interaction Site with the Mitochondrial Import Receptor Tom70 by Zanphorlin, Leticia M., Lima, Tatiani B., Wong, Michael J., Balbuena, Tiago S., Minetti, Conceição A.S.A., Remeta, David P., Young, Jason C., Barbosa, Leandro R.S., Gozzo, Fabio C., Ramos, Carlos H.I.

“…To accomplish its crucial role, mitochondria require proteins that are produced in the cytosol, delivered by cytosolic Hsp90, and translocated to its interior…”
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What Drives Proteins into the Major or Minor Grooves of DNA? by Privalov, Peter L., Dragan, Anatoly I., Crane-Robinson, Colyn, Breslauer, Kenneth J., Remeta, David P., Minetti, Conceição A.S.A.

“…The energetic profiles of a significant number of protein–DNA systems at 20 °C reveal that, despite comparable Gibbs free energies, association with the major…”
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Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion by Chen, Li, Ai, Xuanjun, Portaliou, Athina G., Minetti, Conceicao A.S.A., Remeta, David P., Economou, Anastassios, Kalodimos, Charalampos G.

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Intrinsic local destabilization of the C‐terminus predisposes integrin α1 I domain to a conformational switch induced by collagen binding by Nunes, Ana Monica, Zhu, Jie, Jezioro, Jacqueline, Minetti, Conceição A.S.A., Remeta, David P., Farndale, Richard W., Hamaia, Samir W., Baum, Jean

“…Integrin–collagen interactions play a critical role in a myriad of cellular functions that include immune response, and cell development and differentiation,…”
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Impact of thymine glycol damage on DNA duplex energetics: Correlations with lesion-induced biochemical and structural consequences by Minetti, Conceição A. S. A., Remeta, David P., Iden, Charles R., Johnson, Francis, Grollman, Arthur P., Breslauer, Kenneth J.

“…ABSTRACT The magnitude and nature of lesion‐induced energetic perturbations empirically correlate with mutagenicity/cytotoxicity profiles and can be predictive…”
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Energetics of membrane protein folding and stability by Minetti, Conceição A.S.A., Remeta, David P.

“…The critical role of membrane proteins in a myriad of biological and physiological functions has spawned numerous investigations over the past several decades…”
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Energetic signatures of single base bulges: thermodynamic consequences and biological implications by Minetti, Conceição A.S.A, Remeta, David P, Dickstein, Rian, Breslauer, Kenneth J

“…DNA bulges are biologically consequential defects that can arise from template-primer misalignments during replication and pose challenges to the cellular DNA…”
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Massively parallel, computationally guided design of a proenzyme by Yachnin, Brahm J, Azouz, Laura R, White, 3rd, Ralph E, Minetti, Conceição A S A, Remeta, David P, Tan, Victor M, Drake, Justin M, Khare, Sagar D

“…Confining the activity of a designed protein to a specific microenvironment would have broad-ranging applications, such as enabling cell type-specific…”
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The Thermodynamics of Template-Directed DNA Synthesis: Base Insertion and Extension Enthalpies by Conceição A. S. A. Minetti, Remeta, David P., Miller, Holly, Gelfand, Craig A., Plum, G. Eric, Grollman, Arthur P., Breslauer, Kenneth J.

“…We used stopped-flow calorimetry to measure the overall enthalpy change associated with template-directed nucleotide insertion and DNA extension. Specifically,…”
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Acid-Induced Changes in Thermal Stability and Fusion Activity of Influenza Hemagglutinin by Remeta, David P, Krumbiegel, Mathias, Minetti, Conceição A. S. A, Puri, Anu, Ginsburg, Ann, Blumenthal, Robert

“…The conformational and thermal stability of full-length hemagglutinin (HA) of influenza virus (strain X31) has been investigated using a combination of…”
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Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase by Crowther, Robert L., Remeta, David P., Minetti, Conceição A.S.A., Das, Debanu, Montano, Sherwin P., Georgiadis, Millie M.

“…Reverse transcriptase is an essential retroviral enzyme that replicates the single‐stranded RNA genome of the retrovirus producing a double‐stranded DNA copy,…”
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Characterization of the structure, function, and conformational stability of PorB class 3 protein from Neisseria meningitidis. A porin with unusual physicochemical properties by Minetti, C A, Blake, M S, Remeta, D P

“…PorB proteins constitute the vast majority of channels in neisserial outer membranes and can be subdivided within meningococcal strains into two distinct and…”
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Structural and functional characterization of a recombinant PorB class 2 protein from Neisseria meningitidis. Conformational stability and porin activity by Minetti, C A, Tai, J Y, Blake, M S, Pullen, J K, Liang, S M, Remeta, D P

“…An outer membrane PorB class 2 protein from Neisseria meningitidis has been overexpressed in Escherichia coli, isolated from inclusion bodies, and refolded in…”
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