Search Results - "Minet, Emmanuel"

Application of text mining to develop AOP-based mucus hypersecretion genesets and confirmation with in vitro and clinical samples by Minet, Emmanuel, Haswell, Linsey E., Corke, Sarah, Banerjee, Anisha, Baxter, Andrew, Verrastro, Ivan, De Abreu e Lima, Francisco, Jaunky, Tomasz, Santopietro, Simone, Breheny, Damien, Gaça, Marianna D.

“…Mucus hypersecretion contributes to lung function impairment observed in COPD (chronic obstructive pulmonary disease), a tobacco smoking-related disease. A…”
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Reduced biological effect of e-cigarette aerosol compared to cigarette smoke evaluated in vitro using normalized nicotine dose and RNA-seq-based toxicogenomics by Haswell, Linsey E., Baxter, Andrew, Banerjee, Anisha, Verrastro, Ivan, Mushonganono, Jessica, Adamson, Jason, Thorne, David, Gaça, Marianna, Minet, Emmanuel

“…Electronic cigarettes (e-cigarettes) use has increased globally and could potentially offer a lower risk alternative to cigarette smoking. Here, we assessed…”
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In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke by Haswell, Linsey E., Corke, Sarah, Verrastro, Ivan, Baxter, Andrew, Banerjee, Anisha, Adamson, Jason, Jaunky, Tomasz, Proctor, Christopher, Gaça, Marianna, Minet, Emmanuel

“…The battery of regulatory tests used to evaluate the risk of novel tobacco products such as heated tobacco products (THPs) presents some limitations including…”
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Urinary biomarkers of smokers' exposure to tobacco smoke constituents in tobacco products assessment: a fit for purpose approach by Gregg, Evan O., Minet, Emmanuel, McEwan, Michael

“…Abstract There are established guidelines for bioanalytical assay validation and qualification of biomarkers. In this review, they were applied to a panel of…”
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Mitoferrin is essential for erythroid iron assimilation by Paw, Barry H, Shaw, George C, Cope, John J, Li, Liangtao, Corson, Kenneth, Hersey, Candace, Ackermann, Gabriele E, Gwynn, Babette, Lambert, Amy J, Wingert, Rebecca A, Traver, David, Trede, Nikolaus S, Barut, Bruce A, Zhou, Yi, Minet, Emmanuel, Donovan, Adriana, Brownlie, Alison, Balzan, Rena, Weiss, Mitchell J, Peters, Luanne L, Kaplan, Jerry, Zon, Leonard I

“…Iron has a fundamental role in many metabolic processes, including electron transport, deoxyribonucleotide synthesis, oxygen transport and many essential redox…”
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Multiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers by Kaluarachchi, Manuja R, Boulangé, Claire L, Garcia-Perez, Isabel, Lindon, John C, Minet, Emmanuel F

“…Determining perturbed biochemical functions associated with tobacco smoking should be helpful for establishing causal relationships between exposure and…”
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CYP1A1/1B1 and CYP2A6/2A13 activity is conserved in cultures of differentiated primary human tracheobronchial epithelial cells by Newland, Nik, Baxter, Andrew, Hewitt, Katherine, Minet, Emmanuel

“…► NHTBE cells are primary human tracheobronchial cells. ► NHTBEs are a potential model to study bioactivation of inhaled toxicants in vitro. ► We confirmed…”
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A comparative in vitro kinetic study of [14C]-eugenol and [14C]-methyleugenol activation and detoxification in human, mouse, and rat liver and lung fractions by Minet, Emmanuel F., Daniela, Gentile, Meredith, Clive, Massey, Eian D.

“…Eugenol is a natural alkenylbenzene compound used in a variety of consumer products. There is limited evidence for the carcinogenicity of eugenol to…”
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Hypoxia-inducible Factor-1-dependent Overexpression of Myeloid Cell Factor-1 Protects Hypoxic Cells against tert-Butyl Hydroperoxide-induced Apoptosis by Piret, Jean-Pascal, Minet, Emmanuel, Cosse, Jean-Philippe, Ninane, Noelle, Debacq, Christophe, Raes, Martine, Michiels, Carine

“…Increased levels of Mcl-1 (myeloid cell factor-1) have been reported in several cancers, suggesting an important role played by Mcl-1 in cancer cell survival…”
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An inter-laboratory comparison of urinary 3-hydroxypropylmercapturic acid measurement demonstrates good reproducibility between laboratories by Minet, Emmanuel, Errington, Graham, Scherer, Gerhard, Newland, Kirk, Sharifi, Mehran, Bailey, Brian, McEwan, Mike, Cheung, Francis

“…Biomarkers have been used extensively in clinical studies to assess toxicant exposure in smokers and non-smokers and have recently been used in the evaluation…”
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HIF‐1 and AP‐1 Cooperate to Increase Gene Expression in Hypoxia: Role of MAP Kinases by Michiels, Carine, Minet, Emmanuel, Michel, Gaetan, Mottet, Denis, Piret, Jean‐Pascal, Raes, Martine

“…HIF‐1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT‐1, and glycolytic enzymes are such…”
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Modulation of Interprotomer Relationships Is Important for Activation of Dimeric Calcium-sensing Receptor by Jiang, Yongfeng, Minet, Emmanuel, Zhang, Zaixiang, Silver, Pamela A, Bai, Mei

“…The extracellular calcium-sensing receptor (CaR) forms a disulfide-linked dimer through cysteine residues within its N-terminal extracellular domain (ECD)…”
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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures by Baxter, Andrew, Minet, Emmanuel

“…Xenobiotic metabolizing enzymes play a key function in the biotransformation of medicines and toxicants by adding functional groups that increase solubility…”
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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures by Baxter, Andrew, Minet, Emmanuel

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Targeted omics analyses, and metabolic enzyme activity assays demonstrate maintenance of key mucociliary characteristics in long term cultures of reconstituted human airway epithelia by Baxter, Andrew, Thain, Simon, Banerjee, Anisha, Haswell, Linsey, Parmar, Aleesha, Phillips, Gary, Minet, Emmanuel

“…•Characterization of long term MucilAir™ cultures to evaluate suitability for repeat-dose testing of inhaled chemicals.•Airway surface liquid marker proteins…”
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Metabolic characterization of cell systems used in in vitro toxicology testing: Lung cell system BEAS-2B as a working example by Garcia-Canton, Carolina, Minet, Emmanuel, Anadon, Arturo, Meredith, Clive

“…•Some in vitro cell systems have deficiencies in their metabolism.•BEAS-2B cells are used in the field of pollutants, tobacco and nanomaterials.•Characterizing…”
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Assessing modified risk tobacco and nicotine products: Description of the scientific framework and assessment of a closed modular electronic cigarette by Murphy, James, Gaca, Marianna, Lowe, Frazer, Minet, Emmanuel, Breheny, Damien, Prasad, Krishna, Camacho, Oscar, Fearon, Ian M., Liu, Chuan, Wright, Christopher, McAdam, Kevin, Proctor, Christopher

“…Cigarette smoking causes many human diseases including cardiovascular disease, lung disease and cancer. Novel tobacco products with reduced yields of toxicants…”
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A genome-wide in situhybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain by McKee, Adrienne E, Minet, Emmanuel, Stern, Charlene, Riahi, Shervin, Stiles, Charles D, Silver, Pamela A

“…Abstract Background In eukaryotic cells, RNA-binding proteins (RBPs) contribute to gene expression by regulating the form, abundance, and stability of both…”
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Quantification of plasma microRNAs in a group of healthy smokers, ex-smokers and non-smokers and correlation to biomarkers of tobacco exposure by Banerjee, Anisha, Waters, David, Camacho, Oscar M., Minet, Emmanuel

“…Abstract The stability of circulating miRNAs, their non-invasive sampling techniques and deregulation in diseases make them potential candidate biomarkers of…”
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In vitro RNA-seq-based toxicogenomics assessment of two heated tobacco products shows device-specific transcriptomic response by Haswell, Linsey E., Corke, Sarah, Verrastro, Ivan, Baxter, Andrew, Banerjee, Anisha, Adamson, Jason, Jaunky, Tomasz, Gaca, Marianna, Minet, Emmanuel

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