Search Results - "Miners, Kelly"

CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin by McCully, Michelle L, Ladell, Kristin, Andrews, Robert, Jones, Rhiannon E, Miners, Kelly L, Roger, Laureline, Baird, Duncan M, Cameron, Mark J, Jessop, Zita M, Whitaker, Iain S, Davies, Eleri L, Price, David A, Moser, Bernhard

“…Human skin harbors two major T cell compartments of equal size that are distinguished by expression of the chemokine receptor CCR8. In vitro studies have…”
Get full text

The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus by Murrell, Isa, Bedford, Carmen, Ladell, Kristin, Miners, Kelly L., Price, David A., Tomasec, Peter, Wilkinson, Gavin W. G., Stanton, Richard J.

“…Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire mutations that impact viral growth. These laboratory-adapted strains of…”
Get full text

T cell memory revisited using single telomere length analysis by Roger, Laureline, Miners, Kelly L, Leonard, Louise, Grimstead, Julia W, Price, David A, Baird, Duncan M, Ladell, Kristin

“…The fundamental basis of T cell memory remains elusive. It is established that antigen stimulation drives clonal proliferation and differentiation, but the…”
Get full text

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux by Ahmed, Raya, Roger, Laureline, Costa del Amo, Pedro, Miners, Kelly L., Jones, Rhiannon E., Boelen, Lies, Fali, Tinhinane, Elemans, Marjet, Zhang, Yan, Appay, Victor, Baird, Duncan M., Asquith, Becca, Price, David A., Macallan, Derek C., Ladell, Kristin

“…Adaptive immunity requires the generation of memory T cells from naive precursors selected in the thymus. The key intermediaries in this process are stem…”
Get full text

CD57+ Memory T Cells Proliferate In Vivo by Ahmed, Raya, Miners, Kelly L., Lahoz-Beneytez, Julio, Jones, Rhiannon E., Roger, Laureline, Baboonian, Christina, Zhang, Yan, Wang, Eddie C.Y., Hellerstein, Marc K., McCune, Joseph M., Baird, Duncan M., Price, David A., Macallan, Derek C., Asquith, Becca, Ladell, Kristin

“…A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells…”
Get full text

Sepsis shapes the human γδ TCR repertoire in an age‐ and pathogen‐dependent manner by Giannoni, Eric, Sanchez Sanchez, Guillem, Verdebout, Isoline, Papadopoulou, Maria, Rezwani, Moosa, Ahmed, Raya, Ladell, Kristin, Miners, Kelly L., McLaren, James E., Fraser, Donald J., Price, David A., Eberl, Matthias, Agyeman, Philipp K.A., Schlapbach, Luregn J, Vermijlen, David

“…Sepsis affects 25 million children per year globally, leading to 2.9 million deaths and substantial disability in survivors. Extensive characterization of…”
Get full text

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans by Edwards, Sarah C, Sutton, Caroline E, Ladell, Kristin, Grant, Emma J, McLaren, James E, Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L, Lalor, Stephen J, Ribot, Julie C, Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A, Thomas, Paul G, McLoughlin, Rachel M, Mills, Kingston H G

“…T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in…”
Get full text

IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine by McLaren, James E, Clement, Mathew, Marsden, Morgan, Miners, Kelly L, Llewellyn-Lacey, Sian, Grant, Emma J, Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A, Orr, Selinda J, Stanton, Richard J, Ladell, Kristin, Price, David A, Humphreys, Ian R

“…Candidate vaccines designed to generate T cell-based immunity are typically vectored by nonpersistent viruses, which largely fail to elicit durable effector…”
Get full text

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response by Culshaw, Abigail, Ladell, Kristin, Gras, Stephanie, McLaren, James E, Miners, Kelly L, Farenc, Carine, van den Heuvel, Heleen, Gostick, Emma, Dejnirattisai, Wanwisa, Wangteeraprasert, Apirath, Duangchinda, Thaneeya, Chotiyarnwong, Pojchong, Limpitikul, Wannee, Vasanawathana, Sirijitt, Malasit, Prida, Dong, Tao, Rossjohn, Jamie, Mongkolsapaya, Juthathip, Price, David A, Screaton, Gavin R

“…Cross-reactivity to dengue virus serotypes can trigger life-threatening inflammation. Culshaw et al . show that germline-encoded components of…”
Get full text

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways by Rubina, Anzelika, Patel, Mihil, Nightingale, Katie, Potts, Martin, Fielding, Ceri A, Kollnberger, Simon, Lau, Betty, Ladell, Kristin, Miners, Kelly L, Nichols, Jenna, Nobre, Luis, Roberts, Dawn, Trinca, Terrence M, Twohig, Jason P, Vlahava, Virginia-Maria, Davison, Andrew J, Price, David A, Tomasec, Peter, Wilkinson, Gavin W G, Weekes, Michael P, Stanton, Richard J, Wang, Eddie C Y

“…Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is enabled by its remarkable capacity to systematically subvert host immune…”
Get full text

HCMV pUL135 Remodels the Actin Cytoskeleton to Impair Immune Recognition of Infected Cells by Stanton, Richard J., Prod’homme, Virginie, Purbhoo, Marco A., Moore, Melanie, Aicheler, Rebecca J., Heinzmann, Marcus, Bailer, Susanne M., Haas, Jürgen, Antrobus, Robin, Weekes, Michael P., Lehner, Paul J., Vojtesek, Borivoj, Miners, Kelly L., Man, Stephen, Wilkie, Gavin S., Davison, Andrew J., Wang, Eddie C.Y., Tomasec, Peter, Wilkinson, Gavin W.G.

“…Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence. Without immune pressure, laboratory-adapted HCMV strains have undergone…”
Get full text

CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity by Ciacchi, Lisa, van de Garde, Martijn D.B., Ladell, Kristin, Farenc, Carine, Poelen, Martien C.M., Miners, Kelly L., Llerena, Carmen, Reid, Hugh H., Petersen, Jan, Price, David A., Rossjohn, Jamie, van Els, Cécile A.C.M.

“…CD4+ T cell-mediated immunity against Streptococcus pneumoniae (pneumococcus) can protect against recurrent bacterial colonization and invasive pneumococcal…”
Get full text

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids by Wun, Kwok S., Reijneveld, Josephine F., Cheng, Tan-Yun, Ladell, Kristin, Uldrich, Adam P., Le Nours, Jérôme, Miners, Kelly L., McLaren, James E., Grant, Emma J., Haigh, Oscar L., Watkins, Thomas S., Suliman, Sara, Iwany, Sarah, Jimenez, Judith, Calderon, Roger, Tamara, Kattya L., Leon, Segundo R., Murray, Megan B., Mayfield, Jacob A., Altman, John D., Purcell, Anthony W., Miles, John J., Godfrey, Dale I., Gras, Stephanie, Price, David A., Van Rhijn, Ildiko, Moody, D. Branch, Rossjohn, Jamie

“…The hallmark function of αβ T cell antigen receptors (TCRs) involves the highly specific co-recognition of a major histocompatibility complex molecule and its…”
Get full text

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor by Clement, Mathew, Knezevic, Lea, Dockree, Tamsin, McLaren, James E., Ladell, Kristin, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K., Sewell, Andrew K., Bridgeman, John S., Price, David A., van den Berg, Hugo A., Wooldridge, Linda

“…CD8⁺ T cells are inherently cross-reactive and recognize numerous peptide antigens in the context of a given major histocompatibility complex class I (MHCI)…”
Get full text

Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus by Vlahava, Virginia-Maria, Murrell, Isa, Zhuang, Lihui, Aicheler, Rebecca J, Lim, Eleanor, Miners, Kelly L, Ladell, Kristin, Suárez, Nicolás M, Price, David A, Davison, Andrew J, Wilkinson, Gavin Wg, Wills, Mark R, Weekes, Michael P, Wang, Eddie Cy, Stanton, Richard J

“…Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease following congenital infection and in immunocompromised individuals. No…”
Get full text

Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells by Man, Stephen, Redman, James E, Cross, Deborah L, Cole, David K, Can, Ilona, Davies, Bethan, Hashimdeen, Shaikh Shimaz, Reid, Reiss, Llewellyn-Lacey, Sian, Miners, Kelly L, Ladell, Kristin, Lissina, Anya, Brown, Paul E, Wooldridge, Linda, Price, David A, Rizkallah, Pierre J

“…The human CD8 T cell clone 6C5 has previously been shown to recognize the -butyl-modified Bax peptide LLSY(3- Bu)FGTPT presented by HLA-A*02:01. This…”
Get full text

Inhibitory IL-10-producing CD4 + T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1 by Clement, Mathew, Ladell, Kristin, Miners, Kelly L, Marsden, Morgan, Chapman, Lucy, Cardus Figueras, Anna, Scott, Jake, Andrews, Robert, Clare, Simon, Kriukova, Valeriia V, Lupyr, Ksenia R, Britanova, Olga V, Withers, David R, Jones, Simon A, Chudakov, Dmitriy M, Price, David A, Humphreys, Ian R

“…Inhibitory CD4 T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the…”
Get full text

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene by Van Braeckel-Budimir, Natalija, Gras, Stephanie, Ladell, Kristin, Josephs, Tracy M., Pewe, Lecia, Urban, Stina L., Miners, Kelly L., Farenc, Carine, Price, David A., Rossjohn, Jamie, Harty, John T.

“…Immune response (Ir) genes, originally proposed by Baruj Benacerraf to explain differential antigen-specific responses in animal models, have become synonymous…”
Get full text

Functionally specialized human CD4 + T-cell subsets express physicochemically distinct TCRs by Kasatskaya, Sofya A, Ladell, Kristin, Egorov, Evgeniy S, Miners, Kelly L, Davydov, Alexey N, Metsger, Maria, Staroverov, Dmitry B, Matveyshina, Elena K, Shagina, Irina A, Mamedov, Ilgar Z, Izraelson, Mark, Shelyakin, Pavel V, Britanova, Olga V, Price, David A, Chudakov, Dmitriy M

“…The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4 T cells, but it has remained unclear to what…”
Get full text

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness by Costa Del Amo, Pedro, Lahoz-Beneytez, Julio, Boelen, Lies, Ahmed, Raya, Miners, Kelly L, Zhang, Yan, Roger, Laureline, Jones, Rhiannon E, Marraco, Silvia A Fuertes, Speiser, Daniel E, Baird, Duncan M, Price, David A, Ladell, Kristin, Macallan, Derek, Asquith, Becca

“…Adaptive immunity relies on the generation and maintenance of memory T cells to provide protection against repeated antigen exposure. It has been hypothesised…”
Get full text