Search Results - "Miner, Stephanie J."

Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies by He, Tongchen, Xiao, Lanbo, Qiao, Yuanyuan, Klingbeil, Olaf, Young, Eleanor, Wu, Xiaoli S, Mannan, Rahul, Mahapatra, Somnath, Redin, Esther, Cho, Hanbyul, Bao, Yi, Kandarpa, Malathi, Ching-Yi Tien, Jean, Wang, Xiaoju, Eyunni, Sanjana, Zheng, Yang, Kim, NamHoon, Zheng, Heng, Hou, Siyu, Su, Fengyun, Miner, Stephanie J, Mehra, Rohit, Cao, Xuhong, Abbineni, Chandrasekhar, Samajdar, Susanta, Ramachandra, Murali, Dhanasekaran, Saravana M, Talpaz, Moshe, Parolia, Abhijit, Rudin, Charles M, Vakoc, Christopher R, Chinnaiyan, Arul M

“…The POU2F3-POU2AF2/3 transcription factor complex is the master regulator of the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we…”
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Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer by He, Tongchen, Cheng, Caleb, Qiao, Yuanyuan, Cho, Hanbyul, Young, Eleanor, Mannan, Rahul, Mahapatra, Somnath, Miner, Stephanie J, Zheng, Yang, Kim, NamHoon, Zeng, Victoria Z, Wisniewski, Jasmine P, Hou, Siyu, Jackson, Bailey, Cao, Xuhong, Su, Fengyun, Wang, Rui, Chang, Yu, Kuila, Bilash, Mukherjee, Subhendu, Dukare, Sandeep, Aithal, Kiran B, D S, Samiulla, Abbineni, Chandrasekhar, Vaishampayan, Ulka, Lyssiotis, Costas A, Parolia, Abhijit, Xiao, Lanbo, Chinnaiyan, Arul M

“…Mammalian switch/sucrose nonfermentable (mSWI/SNF) ATPase degraders have been shown to be effective in enhancer-driven cancers by functioning to impede…”
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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition by Chang, Yu, Wang, Xiaoju, Yang, Jianzhang, Tien, Jean Ching-Yi, Mannan, Rahul, Cruz, Gabriel, Zhang, Yuping, Vo, Josh N., Magnuson, Brian, Mahapatra, Somnath, Cho, Hanbyul, Dhanasekaran, Saravana Mohan, Wang, Cynthia, Wang, Zhen, Zhou, Licheng, Zhou, Kaijie, Zhou, Yang, Zhang, Pujuan, Huang, Weixue, Xiao, Lanbo, Liu, Weihuang Raymond, Hamadeh, Rudana, Su, Fengyun, Wang, Rui, Miner, Stephanie J., Cao, Xuhong, Cheng, Yunhui, Mehra, Rohit, Ding, Ke, Chinnaiyan, Arul M.

“…Cyclin-dependent kinases 12/13 play pivotal roles in orchestrating transcription elongation, DNA damage response, and maintenance of genomic stability…”
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CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13 by Tien, Jean Ching-Yi, Luo, Jie, Chang, Yu, Zhang, Yuping, Cheng, Yunhui, Wang, Xiaoju, Yang, Jianzhang, Mannan, Rahul, Mahapatra, Somnath, Shah, Palak, Wang, Xiao-Ming, Todd, Abigail J., Eyunni, Sanjana, Cheng, Caleb, Rebernick, Ryan J., Xiao, Lanbo, Bao, Yi, Neiswender, James, Brough, Rachel, Pettitt, Stephen J., Cao, Xuhong, Miner, Stephanie J., Zhou, Licheng, Wu, Yi-Mi, Labanca, Estefania, Wang, Yuzhuo, Parolia, Abhijit, Cieslik, Marcin, Robinson, Dan R., Wang, Zhen, Feng, Felix Y., Chou, Jonathan, Lord, Christopher J., Ding, Ke, Chinnaiyan, Arul M.

“…Biallelic loss of cyclin-dependent kinase 12 (CDK12) defines a metastatic castration-resistant prostate cancer (mCRPC) subtype. It remains unclear, however,…”
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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Chugh, Seema, Tien, Jean C., Hon, Jennifer, Kenum, Carson, Mannan, Rahul, Cheng, Yunhui, Li, Chi Chiang, Taher, Zainab I., Delekta, Andrew D., Bawa, Pushpinder Singh, Apel, Ingrid J., Miner, Stephanie J., Cao, Xuhong, Mehra, Rohit, Dhanasekaran, Saravana M., Qiao, Yuanyuan, Mody, Rajen, Chinnaiyan, Arul M.

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