Search Results - "Miner, Philip"

A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation by Miner, Jr, Philip B, Koltun, William D, Wiener, Gregory J, De La Portilla, Marianela, Prieto, Blas, Shailubhai, Kunwar, Layton, Mary Beth, Barrow, Laura, Magnus, Leslie, Griffin, Patrick H

“…This study assessed the efficacy and safety of plecanatide, a guanylate cyclase-C (GC-C) agonist and the first uroguanylin analog approved for the treatment of…”
Get full text

Benefit–Risk Assessment of Plecanatide in the Treatment of Chronic Idiopathic Constipation by Miner, Philip B.

“…Plecanatide, a uroguanylin analog, activates the guanylate cyclase C receptors in the epithelial lining of the gastrointestinal tract in a pH-dependent fashion…”
Get full text

Effect of Treatment on the Risk of Viral Infections in Inflammatory Bowel Disease by Miner, Philip B.

Get full text

Irritable Bowel Syndrome Symptoms Following Giardiasis by Miner, Philip B.

Get full text

Elobixibat, the first-in-class Ileal Bile Acid Transporter inhibitor, for the treatment of Chronic Idiopathic Constipation by Miner, Jr, Philip B

“…Elobixibat is the first in class ileal bile acid transporter (IBAT) inhibitor. IBAT inhibitors block ileal absorption of bile acids by: (1) interrupting the…”
Get more information

Response to Currie et al by Miner, Philip B

Get full text

Plecanatide for the treatment of constipation-predominant irritable bowel syndrome by Miner, Philip B

“…: As an analogue of uroguanylin plecanatide binds to the Guanylate Cyclase-C receptor activating fluid and ion secretion in the small intestine with the same…”
Get more information

Efficacy and safety of plecanatide in treating constipation predominant irritable bowel syndrome by Miner, Jr, Philip B

“…Uroguanylin interacting with intestinal Guanylate Cyclase C (GC-C) receptors plays an important role in gastrointestinal fluid and electrolyte homeostasis…”
Get more information

Plecanatide for the Treatment of Chronic Idiopathic Constipation: An Analysis of Patient-Reported Symptoms Associated with Constipation by Miner, Philip B, Shailubhai, Kunwar, Barrow, Laura

Get full text

Economic and personal impact of fecal and urinary incontinence by Miner, Philip B

“…Failure to control the elimination of urine or stool causes psychological stress, complicates medical illnesses and management, and has major economic…”
Get full text

Long-Term Safety and Effectiveness of Lubiprostone, a Chloride Channel (ClC-2) Activator, in Patients with Chronic Idiopathic Constipation by Lembo, Anthony J., Johanson, John F., Parkman, Henry P., Rao, Satish S., Miner, Philip B., Ueno, Ryuji

“…Background Lubiprostone helps relieve constipation in short-term 4-week studies. There are limited data on long-term pharmacological treatment with…”
Get full text

Influence of Demographic Factors on Clinical Outcomes in Adults With Chronic Idiopathic Constipation Treated With Plecanatide by Rao, Satish S.C., Laitman, Adam P., Miner, Philip B.

“…Chronic idiopathic constipation (CIC) is a common condition that affects some patient groups more often. Demographic/clinical characteristics can differ in…”
Get full text

Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study by Miner, Philip, Katz, Philip O, Chen, Yusong, Sostek, Mark

“…Proton pump inhibitors owe their clinical efficacy to their ability to suppress gastric acid production. The objective of this study was to evaluate and…”
Get full text

Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies by Goel, Gautam, King, Tim, Daveson, A James, Andrews, Jane M, Krishnarajah, Janakan, Krause, Richard, Brown, Gregor J E, Fogel, Ronald, Barish, Charles F, Epstein, Roger, Kinney, Timothy P, Miner, Jr, Philip B, Tye-Din, Jason A, Girardin, Adam, Taavela, Juha, Popp, Alina, Sidney, John, Mäki, Markku, Goldstein, Kaela E, Griffin, Patrick H, Wang, Suyue, Dzuris, John L, Williams, Leslie J, Sette, Alessandro, Xavier, Ramnik J, Sollid, Ludvig M, Jabri, Bana, Anderson, Robert P

“…A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed…”
Get more information

Dose-dependent effects of lesogaberan on reflux measures in patients with refractory gastroesophageal reflux disease: a randomized, placebo-controlled study by Miner, Jr, Philip B, Silberg, Debra G, Ruth, Magnus, Miller, Frank, Pandolfino, John

“…The γ-aminobutyric acid type B-receptor agonist lesogaberan (AZD3355) has been developed for use in patients with gastroesophageal reflux disease (GERD)…”
Get full text

Su1214 Efficacy and Safety of Plecanatide in the Treatment of Chronic Idiopathic Constipation (CIC): Results From a Multicenter Phase III Study (Study-03) by Miner, Philip B, Lentz, John David, Berenguer, Ramon, Nualart, Maria, Hickey, Bernadette, Barrow, Laura, Griffin, Patrick

Get full text

New pharmacological treatment options for irritable bowel syndrome with constipation by Nusrat, Salman, Miner, Jr, Philip B

“…Constipation predominant irritable bowel syndrome (IBS-C) is a common disorder and accounts for a large number of ambulatory visits. Sensory abnormalities,…”
Get more information

A Pilot, Phase IV, Randomized, Double-Blind, Placebo-Controlled Trial Investigating the Correlation Between Acid Control and Heartburn Relief During 14 Days of Treatment with Esomeprazole 20 Mg by Miner, Philip B, Johnson, David A, Katz, Philip O, Li, Jing, Gatoulis, Sergio C, Pollack, Charles

Get full text

Sa1440 A Phase III Study of the Efficacy and Safety of Plecanatide in the Treatment of Chronic Idiopathic Constipation (CIC) (Study-00) by Miner, Philip B, Prieto, Blas, De La Portilla, Marianela, Koltun, William, Layton, Mary Beth, Barrow, Laura, Magnus, Leslie

Get full text

Pilot, Randomized, Blinded, Placebo-Controlled Trial Investigating the Correlation Between Acid Control and Heartburn Relief with 14 Days of Esomeprazole Treatment by Miner, Philip B., Johnson, David A., Katz, Philip O., Li, Jing, Gatoulis, Sergio C., Pollack, Charles

“…Introduction Reflux symptoms are frequently associated with esophageal acid exposure. However, other potential causes unrelated to acid secretion are possible,…”
Get full text