Search Results - "Miner, Cathrine A"

STING-associated vasculopathy develops independently of IRF3 in mice by Warner, James D, Irizarry-Caro, Ricardo A, Bennion, Brock G, Ai, Teresa L, Smith, Amber M, Miner, Cathrine A, Sakai, Tomomi, Gonugunta, Vijay K, Wu, Jianjun, Platt, Derek J, Yan, Nan, Miner, Jonathan J

“…Patients with stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) develop systemic inflammation characterized by…”
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A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice by Bennion, Brock G, Ingle, Harshad, Ai, Teresa L, Miner, Cathrine A, Platt, Derek J, Smith, Amber M, Baldridge, Megan T, Miner, Jonathan J

“…We previously generated STING N153S knock-in mice that have a human disease-associated gain-of-function mutation in STING. Patients with this mutation (STING…”
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Acquisition of activation receptor ligand by trogocytosis renders NK cells hyporesponsive by Miner, Cathrine A, Giri, Tusar K, Meyer, Claire E, Shabsovich, Mark, Tripathy, Sandeep K

“…Because NK cells secrete cytotoxic granules and cytokines that can destroy surrounding cells and help shape the subsequent immune response, they must be kept…”
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The ARID Family Transcription Factor Bright Is Required for both Hematopoietic Stem Cell and B Lineage Development by Webb, Carol F., Bryant, James, Popowski, Melissa, Allred, Laura, Kim, Dongkoon, Harriss, June, Schmidt, Christian, Miner, Cathrine A., Rose, Kira, Cheng, Hwei-Ling, Griffin, Courtney, Tucker, Philip W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice by Stinson, W. Alexander, Miner, Cathrine A., Zhao, Fang R., Lundgren, Annena Jane, Poddar, Subhajit, Miner, Jonathan J.

“…STING gain-of-function mutations cause STING-associated vasculopathy with onset in infancy (SAVI) in humans, a disease characterized by spontaneous lung…”
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Loss of Bright/ARID3a Function Promotes Developmental Plasticity by An, Guangyu, Miner, Cathrine A., Nixon, Jamee C., Kincade, Paul W., Bryant, James, Tucker, Philip W., Webb, Carol F.

“…B‐cell regulator of immunoglobulin heavy chain transcription (Bright)/ARID3a, an A+T‐rich interaction domain protein, was originally discovered in B lymphocyte…”
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Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling by Fisher, Daniel A. C., Miner, Cathrine A., Engle, Elizabeth K., Hu, Hengrui, Collins, Taylor B., Zhou, Amy, Allen, Maggie J., Malkova, Olga N., Oh, Stephen T.

“…The distinct clinical features of myelofibrosis (MF) have been attributed in part to dysregulated inflammatory cytokine production. Circulating cytokine levels…”
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STING-associated lung disease in mice relies on T cells but not type I interferon by Luksch, Hella, Stinson, W. Alexander, Platt, Derek J., Qian, Wei, Kalugotla, Gowri, Miner, Cathrine A., Bennion, Brock G., Gerbaulet, Alexander, Rösen-Wolff, Angela, Miner, Jonathan J.

“…Monogenic interferonopathies are thought to be mediated by type I interferon. For example, a gain-of-function mutation in stimulator of interferon genes…”
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A Human STAT1 Gain-of-Function Mutation Impairs CD8 + T Cell Responses against Gammaherpesvirus 68 by Qian, Wei, Miner, Cathrine A, Ingle, Harshad, Platt, Derek J, Baldridge, Megan T, Miner, Jonathan J

“…Autosomal dominant STAT1 mutations in humans have been associated with chronic mucocutaneous candidiasis (CMC), as well as with increased susceptibility to…”
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Transferrable protection by gut microbes against STING-associated lung disease by Platt, Derek J., Lawrence, Dylan, Rodgers, Rachel, Schriefer, Lawrence, Qian, Wei, Miner, Cathrine A., Menos, Amber M., Kennedy, Elizabeth A., Peterson, Stefan T., Stinson, W. Alexander, Baldridge, Megan T., Miner, Jonathan J.

“…STING modulates immunity by responding to bacterial and endogenous cyclic dinucleotides (CDNs). Humans and mice with STING gain-of-function mutations develop a…”
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The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production by Oldham, Athenia L., Miner, Cathrine A., Wang, Hong-Cheng, Webb, Carol F.

“…► The transcription factor Bright was over-expressed in murine B lineage cells. ► Bright over-expression skewed mature B cell development toward marginal zone…”
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Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling by Hansen, Anne Louise, Buchan, Gregory J., Rühl, Michael, Mukai, Kojiro, Salvatore, Sonia R., Ogawa, Emari, Andersen, Sidsel D., Iversen, Marie B., Thielke, Anne L., Gunderstofte, Camilla, Motwani, Mona, Møller, Charlotte T., Jakobsen, Andreas S., Fitzgerald, Katherine A., Roos, Jessica, Lin, Rongtuan, Maier, Thorsten J., Goldbach-Mansky, Raphaela, Miner, Cathrine A., Qian, Wei, Miner, Jonathan J., Rigby, Rachel E., Rehwinkel, Jan, Jakobsen, Martin R., Arai, Hiroyuki, Taguchi, Tomohiko, Schopfer, Francisco J., Olagnier, David, Holm, Christian K.

“…The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs in response to infection with DNA viruses and to presence of host…”
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Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NF[kappa]B signaling by Fisher, Daniel A. C, Miner, Cathrine A, Engle, Elizabeth K, Hu, Hengrui, Collins, Taylor B, Zhou, Amy, Allen, Maggie J

“…The distinct clinical features of myelofibrosis (MF) have been attributed in part to dysregulated inflammatory cytokine production. Circulating cytokine levels…”
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Mass Cytometry Analysis of Dysregulated Cytokine Production and Intracellular Signaling in Myelofibrosis by Fisher, Daniel A.C., Miner, Cathrine A., Engle, Elizabeth K., Brost, Taylor M., Malkova, Olga, Oh, Stephen T.

“…Myeloproliferative neoplasms including myelofibrosis (MF) are characterized by a malignant clone containing JAK2 V617F or other mutations leading to…”
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Acquisition of activation receptor ligand by trogocytosis renders natural killercells hyporesponsive by Miner, Cathrine A., Giri, Tusar K., Meyer, Claire E., Shabsovich, Mark, Tripathy, Sandeep K.

“…Since natural killer (NK) cells secrete cytotoxic granules and cytokines which can destroy surrounding cells and help shape the subsequent immune response,…”
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STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice by Bennion, Brock G., Croft, Carys A., Ai, Teresa L., Qian, Wei, Menos, Amber M., Miner, Cathrine A., Frémond, Marie-Louis, Doisne, Jean-Marc, Andhey, Prabhakar S., Platt, Derek J., Bando, Jennifer K., Wang, Erin R., Luksch, Hella, Molina, Thierry J., Roberson, Elisha D.O., Artyomov, Maxim N., Rösen-Wolff, Angela, Colonna, Marco, Rieux-Laucat, Frédéric, Di Santo, James P., Neven, Bénédicte, Miner, Jonathan J.

“…STING gain-of-function causes autoimmunity and immunodeficiency in mice and STING-associated vasculopathy with onset in infancy (SAVI) in humans. Here, we…”
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