Search Results - "Mindrinos, Michael N."

Digital microfluidic assay for protein detection by Mok, Janine, Mindrinos, Michael N., Davis, Ronald W., Javanmard, Mehdi

“…Global studies of the human proteome have revealed a plethora of putative protein biomarkers. However, their application for early disease detection remains at…”
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Genomic responses in mouse models poorly mimic human inflammatory diseases by Seok, Junhee, Warren, H. Shaw, Cuenca, Alex G., Mindrinos, Michael N., Baker, Henry V., Xu, Weihong, Richards, Daniel R., McDonald-Smith, Grace P., Gao, Hong, Hennessy, Laura, Finnerty, Celeste C., López, Cecilia M., Honari, Shari, Moore, Ernest E., Minei, Joseph P., Cuschieri, Joseph, Bankey, Paul E., Johnson, Jeffrey L., Sperry, Jason, Nathens, Avery B., Billiar, Timothy R., West, Michael A., Jeschke, Marc G., Klein, Matthew B., Gamelli, Richard L., Gibran, Nicole S., Brownstein, Bernard H., Miller-Graziano, Carol, Calvano, Steve E., Mason, Philip H., Cobb, J. Perren, Rahme, Laurence G., Lowry, Stephen F., Maier, Ronald V., Moldawer, Lyle L., Herndon, David N., Davis, Ronald W., Xiao, Wenzhong, Tompkins, Ronald G.

“…A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and…”
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Mice are not men by Warren, H. Shaw, Tompkins, Ronald G., Moldawer, Lyle L., Seok, Junhee, Xu, Weihong, Mindrinos, Michael N., Maier, Ronald V., Xiao, Wenzhong, Davis, Ronald W.

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A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteria by Que, Yok-Ai, Hazan, Ronen, Strobel, Benjamin, Maura, Damien, He, Jianxin, Kesarwani, Meenu, Panopoulos, Panagiotis, Tsurumi, Amy, Giddey, Marlyse, Wilhelmy, Julie, Mindrinos, Michael N, Rahme, Laurence G

“…Bacteria can be refractory to antibiotics due to a sub-population of dormant cells, called persisters that are highly tolerant to antibiotic exposure. The low…”
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Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device by Talasaz, AmirAli H, Powell, Ashley A, Huber, David E, Berbee, James G, Roh, Kyung-Ho, Yu, Wong, Xiao, Wenzhong, Davis, Mark M, Pease, R. Fabian, Mindrinos, Michael N, Jeffrey, Stefanie S, Davis, Ronald W

“…The enumeration of rare circulating epithelial cells (CEpCs) in the peripheral blood of metastatic cancer patients has shown promise for improved cancer…”
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Molecular indexing enables quantitative targeted RNA sequencing and reveals poor efficiencies in standard library preparations by Fu, Glenn K., Xu, Weihong, Wilhelmy, Julie, Mindrinos, Michael N., Davis, Ronald W., Xiao, Wenzhong, Fodor, Stephen P. A.

“…We present a simple molecular indexing method for quantitative targeted RNA sequencing, in which mRNAs of interest are selectively captured from complex cDNA…”
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A network-based analysis of systemic inflammation in humans by Davis, Ronald W, Calvano, Steve E, Xiao, Wenzhong, Richards, Daniel R, Felciano, Ramon M, Baker, Henry V, Cho, Raymond J, Chen, Richard O, Brownstein, Bernard H, Cobb, J. Perren, Tschoeke, S. Kevin, Miller-Graziano, Carol, Moldawer, Lyle L, Mindrinos, Michael N, Tompkins, Ronald G, Lowry, Stephen F, Large Scale Collab. Res. Program, Inflamm and Host Response to Injury

“…Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize…”
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Analysis of Pseudomonas aeruginosa 4-Hydroxy-2-Alkylquinolines (HAQs) Reveals a Role for 4-Hydroxy-2-Heptylquinoline in Cell-to-Cell Communication by Déziel, Eric, Lépine, François, Milot, Sylvain, He, Jianxin, Mindrinos, Michael N., Tompkins, Ronald G., Rahme, Laurence G.

“…Bacterial communities use "quorum sensing" (QS) to coordinate their population behavior through the action of extracellular signal molecules, such as the…”
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High-quality DNA sequence capture of 524 disease candidate genes by Shen, Peidong, Wang, Wenyi, Krishnakumar, Sujatha, Palm, Curtis, Chi, Aung-Kyaw, Enns, Gregory M, Davis, Ronald W, Speed, Terence P, Mindrinos, Michael N, Scharfe, Curt

“…The accurate and complete selection of candidate genomic regions from a DNA sample before sequencing is critical in molecular diagnostics. Several recently…”
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Profiling Early Infection Responses: Pseudomonas aeruginosa Eludes Host Defenses by Suppressing Antimicrobial Peptide Gene Expression by Apidianakis, Yiorgos, Mindrinos, Michael N., Xiao, Wenzhong, Lau, Gee W., Baldini, Regina L., Davis, Ronald W., Rahme, Laurence G., Ausubel, Frederick M.

“…Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity…”
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Reply to Osterburg et al.: To study human inflammatory diseases in humans by Tompkins, Ronald G, Warren, H Shaw, Mindrinos, Michael N, Xiao, Wenzhong, Davis, Ronald W

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Cell-Specific Expression and Pathway Analyses Reveal Alterations in Trauma-Related Human T Cell and Monocyte Pathways by Laudanski, Krzysztof, Miller-Graziano, Carol, Xiao, Wenzhong, Mindrinos, Michael N., Richards, Daniel R., De, Asit, Moldawer, Lyle L., Maier, Ronald V., Bankey, Paul, Baker, Henry V., Brownstein, Bernard H., Cobb, J. Perren, Calvano, Steve E., Davis, Ronald W., Tompkins, Ronald G.

“…Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for the future of medicine. Patients with injuries…”
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Reply to Cauwels et al.: Of men, not mice, and inflammation by Warren, H Shaw, Tompkins, Ronald G, Mindrinos, Michael N, Xiao, Wenzhong, Davis, Ronald W

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Burn Injury Causes Mitochondrial Dysfunction in Skeletal Muscle by Padfield, Katie E., Astrakas, Loukas G., Zhang, Qunhao, Gopalan, Suresh, Dai, George, Mindrinos, Michael N., Tompkins, Ronald G., Rahme, Laurence G., Tzika, A. Aria, Davis, Ronald W.

“…Severe burn trauma is generally followed by a catabolic response that leads to muscle wasting and weakness affecting skeletal musculature. Here, we perform…”
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Microfluidic Isolation of Leukocytes from Whole Blood for Phenotype and Gene Expression Analysis by Sethu, Palaniappan, Moldawer, Lyle L, Mindrinos, Michael N, Scumpia, Philip O, Tannahill, Cynthia L, Wilhelmy, Julie, Efron, Philip A, Brownstein, Bernard H, Tompkins, Ronald G, Toner, Mehmet

“…Technologies that enable the isolation of cell subtypes from small samples of complex populations will greatly facilitate the implementation of proteomics and…”
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Coding SNPs as intrinsic markers for sample tracking in large-scale transcriptome studies by Xu, Weihong, Gao, Hong, Seok, Junhee, Wilhelmy, Julie, Mindrinos, Michael N, Davis, Ronald W, Xiao, Wenzhong

“…Large-scale transcriptome profiling in clinical studies often involves assaying multiple samples of a patient to monitor disease progression, treatment effect,…”
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A genomic storm in critically injured humans by Xiao, Wenzhong, Mindrinos, Michael N, Seok, Junhee, Cuschieri, Joseph, Cuenca, Alex G, Gao, Hong, Hayden, Douglas L, Hennessy, Laura, Moore, Ernest E, Minei, Joseph P, Bankey, Paul E, Johnson, Jeffrey L, Sperry, Jason, Nathens, Avery B, Billiar, Timothy R, West, Michael A, Brownstein, Bernard H, Mason, Philip H, Baker, Henry V, Finnerty, Celeste C, Jeschke, Marc G, López, M Cecilia, Klein, Matthew B, Gamelli, Richard L, Gibran, Nicole S, Arnoldo, Brett, Xu, Weihong, Zhang, Yuping, Calvano, Steven E, McDonald-Smith, Grace P, Schoenfeld, David A, Storey, John D, Cobb, J Perren, Warren, H Shaw, Moldawer, Lyle L, Herndon, David N, Lowry, Stephen F, Maier, Ronald V, Davis, Ronald W, Tompkins, Ronald G

“…Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma…”
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Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma by Apidianakis, Yiorgos, Mindrinos, Michael N, Xiao, Wenzhong, Tegos, George P, Papisov, Michail I, Hamblin, Michael R, Davis, Ronald W, Tompkins, Ronald G, Rahme, Laurence G

“…Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A…”
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Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines by Powell, Ashley A, Talasaz, Amirali H, Zhang, Haiyu, Coram, Marc A, Reddy, Anupama, Deng, Glenn, Telli, Melinda L, Advani, Ranjana H, Carlson, Robert W, Mollick, Joseph A, Sheth, Shruti, Kurian, Allison W, Ford, James M, Stockdale, Frank E, Quake, Stephen R, Pease, R Fabian, Mindrinos, Michael N, Bhanot, Gyan, Dairkee, Shanaz H, Davis, Ronald W, Jeffrey, Stefanie S

“…To improve cancer therapy, it is critical to target metastasizing cells. Circulating tumor cells (CTCs) are rare cells found in the blood of patients with…”
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Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow by Deng, Glenn, Krishnakumar, Sujatha, Powell, Ashley A, Zhang, Haiyu, Mindrinos, Michael N, Telli, Melinda L, Davis, Ronald W, Jeffrey, Stefanie S

“…Therapeutic decisions in cancer are generally guided by molecular biomarkers or, for some newer therapeutics, primary tumor genotype. However, because…”
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