Search Results - "Minchinton, A I"

Radiobiological effects of altering dose rate in filter-free photon beams by Karan, T, Moiseenko, V, Gill, B, Horwood, R, Kyle, A, Minchinton, A I

“…To validate that altering radiotherapy dose rate through either changing pulse repetition frequency or instantaneous dose rate does not have an effect on cell…”
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Effects of tirapazamine on experimental colorectal liver metastases after radiofrequency ablation by Govaert, K. M., Nijkamp, M. W., Emmink, B. L., Steller, E. J. A., Minchinton, A. I., Kranenburg, O., Borel Rinkes, I. H. M.

“…Background: Radiofrequency ablation (RFA) is a common procedure for the management of colorectal liver metastases. RFA‐generated lesions are surrounded by a…”
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Tissue Discs: A 3D Model for Assessing Modulation of Tissue Oxygenation by Gandolfo, M J, Kyle, A H, Minchinton, A I

“…The presence of hypoxia in solid tumours is correlated with poor treatment outcome. We have developed a 3-D tissue engineered construct to quantitatively…”
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Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma by Cham, K K Y, Baker, J H E, Takhar, K S, Flexman, J A, Wong, M Q, Owen, D A, Yung, A, Kozlowski, P, Reinsberg, S A, Chu, E M, Chang, C-W A, Buczkowski, A K, Chung, S W, Scudamore, C H, Minchinton, A I, Yapp, D T T, Ng, S S W

“…Background: The current standard of care for pancreatic cancer is weekly gemcitabine administered for 3 of 4 weeks with a 1-week break between treatment…”
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Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model by KYLE, A. H, MINCHINTON, A. I

“…Efficient extravascular penetration is essential for the optimal activity of most anticancer drugs and is particularly relevant to bioreductive cytotoxins…”
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Vascularization predicts overall survival and risk of transformation in follicular lymphoma by FARINHA, Pedro, KYLE, Alastair H, MINCHINTON, Andrew I, CONNORS, Joseph M, KARSAN, Aly, GASCOYNE, Randy D

“…Follicular lymphoma patients display heterogeneous overall survival and variable risk of transformation. Recent studies have highlighted the role of the…”
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Carbogen Inhalation in Cervical Cancer: Assessment of Oxygenation Change by Aquino-Parsons, C., Lim, P., Green, A., Minchinton, A.I.

“…Objective. Our objectives were (1) to examine tumor oxygenation measured with an Eppendorf pO2 histograph, prior to and during carbogen (95% oxygen, 5% carbon…”
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The Effect of Deep Inspiration Breath-hold on Tumour Oxygenation by Aquino-Parsons, C., Ries, C.R., Minchinton, A.I., D’yachkova, Y.

“…Aim: To investigate the influence of deep inspiration breath-hold on the oxygen tension of in-vivo tumours measured using an Eppendorf pO 2histograph…”
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Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342 by MINCHINTON, A. I, DURAND, R. E, CHAPLIN, D. J

“…The administration of the fluorescent DNA stain, Hoechst 33342, to mice bearing the KHT sarcoma, combined with flow cytometry, can be used to select cells…”
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Multilayers of cells growing on a permeable support. An in vitro tumour model by Minchinton, A I, Wendt, K R, Clow, K A, Fryer, K H

“…A system for growing three-dimensional cell culture has been developed which exhibits many features of solid tumours. This system comprises cells growing as a…”
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Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathing by MINCHINTON, A. I, BROWN, J. M

“…The bioreductive cytotoxic agent SR 4233 (1,2,4-benzotriazine 3-amine 1,4-dioxide) has been shown to markedly potentiate the cell killing of mouse tumours when…”
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The effect of thalidomide on experimental tumors and metastases by Minchinton, A I, Fryer, K H, Wendt, K R, Clow, K A, Hayes, M M

“…Thalidomide has recently been shown to antagonize basic fibroblast growth factor-induced angiogenesis in the rat corneal micropocket assay. We have…”
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Cytotoxic effect of RB 6145 in human tumour cell lines: dependence on hypoxia, extra- and intracellular pH and drug uptake by SKARSGARD, L. D, ACHESON, D. K, VINCZAN, A, WOUTERS, B. G, HEINRICHS, B. E, LOBLAW, D. A, MINCHINTON, A. I, CHAPLIN, D. J

“…Low pH and hypoxia are a common feature of many solid tumours. This study examined the effect of these two conditions on the cytotoxic properties of the…”
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Characterization of Three-Dimensional Tissue Cultures Using Electrical Impedance Spectroscopy by Kyle, Alastair H., Chan, Carmel T.O., Minchinton, Andrew I.

“…Electrical impedance spectroscopy was used to characterize the cell environment of multilayered cell cultures (MCCs), a culture system in which cells are grown…”
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Pharmacological modification of tumor blood flow: lack of correlation between alteration of mean arterial blood pressure and changes in tumor perfusion by Stone, H B, Minchinton, A I, Lemmon, M, Menke, D, Brown, J M

“…The correlation between mean arterial blood pressure (MABP) and vascular perfusion in SCC-VII/St tumors in mice was compared following administration of three…”
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The hypoxic cytotoxin SR 4233 increases the effectiveness of radioimmunotherapy in mice with human non-Hodgkin's lymphoma xenografts by Wilder, R B, McGann, J K, Sutherland, W R, Waller, E K, Minchinton, A I, Goris, M L, Knox, S J

“…To determine if either the hypoxic cell radiosensitizer etanidazole (SR 2508) or the hypoxic cytotoxin SR 4233 could improve the effectiveness of…”
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Effects of Glutathione Depletion by Buthionine Sulfoximine on Radiosensitization by Oxygen and Misonidazole in Vitro by Shrieve, Dennis C., Denekamp, Juliana, Minchinton, Andrew I.

“…Buthionine sulfoximine (BSO) has been used to deplete glutathione (GSH) in V79-379A cells in vitro, and the effect on the efficiency of oxygen and misonidazole…”
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Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: pharmacology and activity in vitro and in vivo by Minchinton, A I, Lemmon, M J, Tracy, M, Pollart, D J, Martinez, A P, Tosto, L M, Brown, J M

“…SR 4233 (1,2,4-benzotriazine-3-amine 1,4-dioxide) will soon be entering Phase I clinical trials as a new bioreductive cytotoxic agent for the treatment of…”
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Spatial characterization of glutathione depletion in the KHT sarcoma using flow cytometry by Minchinton, A I, Chaplin, D J

“…Intravenous administration of the fluorescent DNA stain Hoechst 33342 to tumour-bearing mice was used to label cells proportionally to their proximity from the…”
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Oxygen tension in primary gynaecological tumours: the influence of carbon dioxide concentration by Aquino-Parsons, Christina, Green, Alex, Minchinton, Andrew I

“…Background and purpose: To assess the effect of inhalation of various high oxygen content gases (HOCG) with different carbon dioxide concentrations on the…”
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