Search Results - "Minato, Yusuke"

Functional and Structural Characterization of Acquired 16S rRNA Methyltransferase NpmB1 Conferring Pan-Aminoglycoside Resistance by Kawai, Akito, Suzuki, Masahiro, Tsukamoto, Kentaro, Minato, Yusuke, Doi, Yohei

“…Posttranslational methylation of the A site of 16S rRNA at position A1408 leads to pan-aminoglycoside resistance encompassing both 4,5- and 4,6-disubstituted…”
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Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole by Minato, Yusuke, Dawadi, Surendra, Kordus, Shannon L., Sivanandam, Abiram, Aldrich, Courtney C., Baughn, Anthony D.

“…Trimethoprim (TMP)-sulfamethoxazole (SMX) is a widely used synergistic antimicrobial combination to treat a variety of bacterial and certain fungal infections…”
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Design, synthesis and conformation-activity relationship analysis of LNA/BNA-type 5′-O-aminoribosyluridine as MraY inhibitors by Kusaka, Shintaro, Yamamoto, Kazuki, Shinohara, Motoko, Minato, Yusuke, Ichikawa, Satoshi

“…[Display omitted] It is important to understand and control the biologically active conformation in medicinal chemistry. Muraymycins and caprazamycins, which…”
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KIF19A Is a Microtubule-Depolymerizing Kinesin for Ciliary Length Control by Niwa, Shinsuke, Nakajima, Kazuo, Miki, Harukata, Minato, Yusuke, Wang, Doudou, Hirokawa, Nobutaka

“…Cilia control homeostasis of the mammalian body by generating fluid flow. It has long been assumed that ciliary length-control mechanisms are essential for…”
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Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways by Minato, Yusuke, Gohl, Daryl M, Thiede, Joshua M, Chacón, Jeremy M, Harcombe, William R, Maruyama, Fumito, Baughn, Anthony D

“…A better understanding of essential cellular functions in pathogenic bacteria is important for the development of more effective antimicrobial agents. We…”
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Genome-wide identification of essential genes in Mycobacterium intracellulare by transposon sequencing — Implication for metabolic remodeling by Tateishi, Yoshitaka, Minato, Yusuke, Baughn, Anthony D., Ohnishi, Hiroaki, Nishiyama, Akihito, Ozeki, Yuriko, Matsumoto, Sohkichi

“…The global incidence of the human nontuberculous mycobacteria (NTM) disease is rapidly increasing. However, knowledge of gene essentiality under optimal growth…”
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Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY by Nakaya, Takeshi, Yabe, Miyuki, Mashalidis, Ellene H., Sato, Toyotaka, Yamamoto, Kazuki, Hikiji, Yuta, Katsuyama, Akira, Shinohara, Motoko, Minato, Yusuke, Takahashi, Satoshi, Horiuchi, Motohiro, Yokota, Shin-ichi, Lee, Seok-Yong, Ichikawa, Satoshi

“…The development of new antibacterial drugs with different mechanisms of action is urgently needed to address antimicrobial resistance. MraY is an essential…”
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Comprehensive analysis of resistance-nodulation-cell division superfamily (RND) efflux pumps from Serratia marcescens, Db10 by Toba, Shinsuke, Minato, Yusuke, Kondo, Yuma, Hoshikawa, Kanami, Minagawa, Shu, Komaki, Shiho, Kumagai, Takanori, Matoba, Yasuyuki, Morita, Daichi, Ogawa, Wakano, Gotoh, Naomasa, Tsuchiya, Tomofusa, Kuroda, Teruo

“…We investigated the role of the resistance-nodulation-cell division superfamily (RND) efflux system on intrinsic multidrug resistance in Serratia marcescens …”
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Attempt of thyX gene silencing and construction of a thyX deleted clone in a Mycobacterium bovis BCG by Arimura, Yuki, Minato, Yusuke, Wada, Takayuki, Nakayama, Masaaki, Ryumon, Ayako, Hirata, Nao, Nakajima, Chie, Suzuki, Yasuhiko, Ato, Manabu, Kobayashi, Kazuo, Ohara, Naoko, Iida, Seiji, Ohara, Naoya

“…Mycobacterium tuberculosis, the causative agent of tuberculosis, possess flavin‐dependent thymidylate synthase, ThyX. Since thyX is absent in humans and was…”
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Long-Chain Fatty Acyl Coenzyme A Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis by Rosen, Brandon C, Dillon, Nicholas A, Peterson, Nicholas D, Minato, Yusuke, Baughn, Anthony D

“…Pyrazinamide (PZA) is a first-line tuberculosis (TB) drug that has been in clinical use for 60 years yet still has an unresolved mechanism of action. Based…”
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Trends in hepatitis C virus‐associated mortality rates in Japan, 1998–2017 by Hagiya, Hideharu, Koyama, Toshihiro, Deguchi, Matsuo, Minato, Yusuke, Miura, Satomi, Funahashi, Tomoko, Teratani, Yusuke, Zamami, Yoshito, Shinomiya, Kazuaki, Kitamura, Yoshihisa, Sendo, Toshiaki, Hinotsu, Shiro, Kano, Mitsunobu

“…Background and Aim The current prevalence of hepatitis C virus infection and hepatitis C virus‐associated mortality in Japan falls short of the World Health…”
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PDCD1 and CTLA4 polymorphisms affect the susceptibility to, and clinical features of, chronic immune thrombocytopenia by Kasamatsu, Tetsuhiro, Ino, Rumi, Takahashi, Noriyuki, Gotoh, Nanami, Minato, Yusuke, Takizawa, Makiko, Yokohama, Akihiko, Handa, Hiroshi, Saitoh, Takayuki, Tsukamoto, Norifumi, Murakami, Hirokazu

“…Summary Programmed death‐1 (PD‐1, PDCD1) and cytotoxic T lymphocyte‐associated antigen‐4 (CTLA‐4, CTLA4) play central roles in immune checkpoint pathways…”
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Characterization of MATE-type multidrug efflux pumps from Klebsiella pneumoniae MGH78578 by Ogawa, Wakano, Minato, Yusuke, Dodan, Hayata, Onishi, Motoyasu, Tsuchiya, Tomofusa, Kuroda, Teruo

“…We previously described the cloning of genes related to drug resistance from Klebsiella pneumoniae MGH78578. Of these, we identified a putative gene encoding a…”
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Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates by Thiede, Joshua M., Kordus, Shannon L., Turman, Breanna J., Buonomo, Joseph A., Aldrich, Courtney C., Minato, Yusuke, Baughn, Anthony D.

“…The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other…”
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Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis by Thiede, Joshua M, Dillon, Nicholas A, Howe, Michael D, Aflakpui, Ranee, Modlin, Samuel J, Hoffner, Sven E, Valafar, Faramarz, Minato, Yusuke, Baughn, Anthony D

“…Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium…”
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Microglia Negatively Regulate the Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells Isolated from Poststroke Mouse Brains by Hirano, Yoshinobu, Nakagomi, Takayuki, Nakano-Doi, Akiko, Kubo, Shuji, Minato, Yusuke, Sawano, Toshinori, Sakagami, Masafumi, Tsuzuki, Kenzo

“…We previously demonstrated that neural stem/progenitor cells (NSPCs) were induced within and around the ischemic areas in a mouse model of ischemic stroke…”
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Association between OGG1 S326C CC genotype and elevated relapse risk in acute myeloid leukemia by Gotoh, Nanami, Saitoh, Takayuki, Takahashi, Noriyuki, Kasamatsu, Tetsuhiro, Minato, Yusuke, Lobna, Alkebsi, Oda, Tsukasa, Hoshino, Takumi, Sakura, Toru, Shimizu, Hiroaki, Takizawa, Makiko, Handa, Hiroshi, Yokohama, Akihiko, Tsukamoto, Norifumi, Murakami, Hirokazu

“…Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base…”
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The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP by Takahashi, Noriyuki, Saitoh, Takayuki, Gotoh, Nanami, Nitta, Yasuhiro, Alkebsi, Lobna, Kasamatsu, Tetsuhiro, Minato, Yusuke, Yokohama, Akihiko, Tsukamoto, Norifumi, Handa, Hiroshi, Murakami, Hirokazu

“…T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of…”
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Interleukin-18 and its receptor are expressed in gonadotropin-releasing hormone neurons of mouse and rat forebrain by Kuwahara-Otani, Sachi, Maeda, Seishi, Kobayashi, Kimiko, Minato, Yusuke, Tanaka, Koichi, Yamanishi, Kyosuke, Hata, Masaki, Li, Wen, Hayakawa, Tetsu, Noguchi, Koichi, Okamura, Haruki, Yagi, Hideshi

“…•IL-18 and IL-18Rα are distributed within the basal forebrain in a continuum that extends from the medial septum through to the anterior hypothalamic…”
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Involvement of 14-3-3 Proteins in the Second Epidermal Growth Factor-induced Wave of Rac1 Activation in the Process of Cell Migration by Kobayashi, Hiroki, Ogura, Yusuke, Sawada, Masato, Nakayama, Ryoji, Takano, Kei, Minato, Yusuke, Takemoto, Yasushi, Tashiro, Etsu, Watanabe, Hidenori, Imoto, Masaya

“…Immense previous efforts have elucidated the core machinery in cell migration, actin remodeling regulated by Rho family small GTPases including RhoA, Cdc42,…”
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