Search Results - "Minato, Hisao"

Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives by Ueda, Shigeo, Terauchi, Hideo, Suzuki, Kenji, Yano, Akihiro, Matsumoto, Masashi, Kubo, Taeko, Minato, Hisao, Arai, Yukiyo, Tsuji, Jun-ichi, Watanabe, Nobuhide

“…The synthesis and evaluation of compound 4 (ES-2133) and its related optically active compounds as iNOS inhibitor is reported. In addition, an alternative…”
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Protective Effect of Zonisamide, an Antiepileptic Drug, Against Transient Focal Cerebral Ischemia with Middle Cerebral Artery Occlusion‐Reperfusion in Rats by Minato, Hisao, Kikuta, Chie, Fujitani, Buichi, Masuda, Yoshinobu

“…Purpose: The antiepileptic effects of zonisamide (ZNS) have been well documented experimentally and clinically. The purpose of this study was to examine…”
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Effect of OS-0689, a novel SERM, on periarterial nerve function in tail arteries of ovariectomized rats by Minato, Hisao, Ikeno, Akihisa, Watanabe, Nobuhide, Tsuji, Jun-ichi

“…We have previously shown that OS-0689 attenuates the rise in tail skin temperature of ovariectomized rats, which is believed to be relevant to human symptoms…”
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4-(4-Alkylpiperazin-1-yl)phenyl group: A novel class of basic side chains for selective estrogen receptor modulators by WATANABE, Nobuhide, NAKAGAWA, Hiroshi, IKENO, Akihisa, MINATO, Hisao, KOHAYAKAWA, Chie, TSUJI, Jun-Ichi

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Inhibitory effect of the new calcium antagonist AJ-2615 on progression of atherosclerosis in cholesterol-fed rabbits by Minato, H, Ikeno, A, Yamada, T, Kato, H, Zushi, K, Kurokawa, M, Masuda, Y, Hosoki, K, Karasawa, T

“…The effects of a new calcium antagonist, AJ-2615, on progression of atherosclerosis were investigated in rabbits fed a diet high in cholesterol and compared…”
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Discovery and Preclinical Characterization of (+)-3-[4-(1- Piperidinoethoxy)phenyl]spiro[indene- 1,1‘-indane]-5,5‘-diol Hydrochloride:  A Promising Nonsteroidal Estrogen Receptor Agonist for Hot Flush by Watanabe, Nobuhide, Ikeno, Akihisa, Minato, Hisao, Nakagawa, Hiroshi, Kohayakawa, Chie, Tsuji, Jun-ichi

“…In our studies of the development of a novel class of selective estrogen receptor modulators,…”
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Effect of OS-0544, a selective estrogen receptor modulator, on endothelial function and increased sympathetic activity in ovariectomized rats by Ikeno, Akihisa, Minato, Hisao, Kohayakawa, Chie, Tsuji, Jun-ichi

“…Abstract Estrogens are known to contribute to endothelial function and sympathetic activity, both of which are strongly associated with the pathogenesis of…”
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4-(4-alkylpiperazin-1-yl)phenyl group: a novel class of basic side chains for selective estrogen receptor modulators by Watanabe, Nobuhide, Nakagawa, Hiroshi, Ikeno, Akihisa, Minato, Hisao, Kohayakawa, Chie, Tsuji, Jun-ichi

“…In the structure-activity relationships of spiro[indene-1,1'-indane] series, the 4-(4-alkylpiperazin-1-yl)phenyl group was found to be functionally equipotent…”
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Effect of AJ-3941 a cerebrovascular-selective calcium antagonist, on cerebral vasospasms in experimental subarachnoid hemorrhage rats by Honda, Yayoi, Minato, Hisao, Masuda, Yoshinobu, Hosoki, Kanoo

“…We reported that AJ-3941((E)-1-(3-Fluoro-6, 11-dihydrodibenz「b,e」 oxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate) was a cerebrovascular-selective…”
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Protective effect of a novel cerebrovascular-selective calcium antagonist, AJ-3941, on ischemic brain damage after permanent middle cerebral artery occlusion in rats by Honda, Yayoi, Minato, Hisao, Masuda, Yoshinobu, Fujitani, Buichi, Hosoki, Kanoo

“…We reported that AJ-3941 was a cerebrovascular selective calcium antagonist which reduced brain damage induced by complete, global or transient ischemia with…”
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AJ-3941. a new calcium antagonist, attenuates phorbol 12,13-dibutyrate-induced vasoconstriction of cerebral arteries in rabbit by Hashizume, Masahide, Minato, Hisao, Fujitani, Buichi, Masuda, Yoshinobu, Hosoki, Kanoo

“…We previously reported that AJ-3941, a new calcium antagonist, had vasospasmolytic action which was selective for cerebral artery (J. Cereb. Blood Flow Metab.,…”
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Corrigendum to “Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives”: [Bioorg. Med. Chem. Lett. 15 (2005) 1361] by Ueda, Shigeo, Terauchi, Hideo, Suzuki, Kenji, Yano, Akihiro, Matsumoto, Masashi, Kubo, Taeko, Minato, Hisao, Arai, Yukiyo, Tsuji, Jun-ichi, Watanabe, Nobuhide

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Effects of Monatepil Maleate, a New Ca2+ Channel Antagonist With α1-Adrenoceptor Antagonistic Activity, on Cholesterol Absorption and Catabolism in High Cholesterol Diet-Fed Rabbits by Ikeno, Akihisa, Sumiya, Toshiki, Minato, Hisao, Fujitani, Buichi, Masuda, Yoshinobu, Hosoki, Kanoo, Kurono, Masuo, Yasuba, Masashi

“…The mechanism of the prophylactic effect against hyperlipidemia by monatepil maleate was investigated in animal models. Monatepil maleate is an…”
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Effects of monatepil on cholesterol absorption and catabolism in cholesterol-fed rabbits by Ikeno, Akihisa, Sumiya, Toshiki, Minato, Hisao, Fujitani, Buichi, Masuda, Yoshinobu, Hosoki, Kanoo

“…Monatepil, a new calcium antagonist endowed a1-adrenoceptor blocking property, exerts plasma-l ipid low-ering and anti-atherosclerotic effects in cholesterol…”
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Effect of aging on blood pressure, locomotor activity and brain monoamine metabolism in SHRSP by Minato, Hisao, Masuda, Yoshinobu, Hosoki, Kanoo

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Effect of AJ-3941, a novel calcium antagonist on the development of stroke in SHRSP by Minato, Hisao, Kato, Hiroshi, Zushi, Kayoko, Masuda, Yoshinobu

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RENAL EXCRETION MECHANISM OF AT-2266 IN DOGS by TAKEYAMA, KUNIHIKO, MINATO, HISAO, KUROBE, NOBUUKI, HOSOKI, KANOO, KADOKAWA, TOSHIAKI, YAMAMOTO, KENJIRO

“…Mechanism of renal excretion of ATAT-2266, a new chemotherapeutic agent, was investigated in anesthetized dogs using renal clearance and stop- flow methods…”
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Prevention by the new Ca 2+ channel antagonist, AJ-3941, of loss of endothelium-dependent relaxation after subarachnoid hemorrhage in rats by Minato, Hisao, Honda, Yayoi, Masuda, Yoshinobu, Fujitani, Buichi, Hosoki, Kanoo

“…AJ-3941 ((±)-( E)-1-(3-fluoro-6,11-dihydrodibenz[ b,e]-oxepine-11-yl)-4-(3-phenyl-2-propenyl)-piperazine dimaleate; CAS No. 143110-70-7), a…”
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Prevention by the new Ca2+ channel antagonist, AJ-3941, of loss of endothelium-dependent relaxation after subarachnoid hemorrhage in rats by MINATO, H, HONDA, Y, MASUDA, Y, FUJITANI, B, HOSOKI, K

“…AJ-3941 ((+/-)-(E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]-oxepine-11-yl ) -4-(3-phenyl-2-propenyl)-piperazine dimaleate; CAS No. 143110-70-7), a…”
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Alacepril, an angiotensin-converting enzyme inhibitor, prevents cerebral vasospasm in subarachnoid hemorrhage model in rats by Honda, Y, Minato, H, Fujitani, B, Masuda, Y, Hosoki, K

“…The effects of angiotensin-converting enzyme (ACE) inhibitors was investigated on the development of cerebral vasospasm and on the endothelium-dependent…”
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