Search Results - "Minamizaki, Tomoko"

Emerging roles of microRNAs as extracellular vesicle cargo secreted from osteoblasts by Yoshiko, Yuji, Minamizaki, Tomoko

“…Extracellular vesicles (EVs) have come into the spotlight as messengers, delivering cargo for cell–cell communication. Concomitantly, increasing attention has…”
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Active sites of human MEPE-ASARM regulating bone matrix mineralization by Minamizaki, Tomoko, Sakurai, Kaoru, Hayashi, Ikue, Toshishige, Masaaki, Yoshioka, Hirotaka, Kozai, Katsuyuki, Yoshiko, Yuji

“…The proteolytic fragment ASARM (acidic serine- and aspartate-rich motif) of MEPE (matrix extracellular phosphoglycoprotein) (MEPE-ASARM) may act as an…”
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Soluble Klotho causes hypomineralization in Klotho-deficient mice by Minamizaki, Tomoko, Konishi, Yukiko, Sakurai, Kaoru, Yoshioka, Hirotaka, Aubin, Jane E, Kozai, Katsuyuki, Yoshiko, Yuji

“…The type I transmembrane protein αKlotho (Klotho) serves as a coreceptor for the phosphaturic hormone fibroblast growth factor 23 (FGF23) in kidney, while a…”
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Functional Diversity of Fibroblast Growth Factors in Bone Formation by Takei, Yuichiro, Yoshiko, Yuji, Minamizaki, Tomoko

“…The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and…”
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Overexpression of Fibroblast Growth Factor 23 Suppresses Osteoblast Differentiation and Matrix Mineralization In Vitro by Wang, Hua, Yoshiko, Yuji, Yamamoto, Ryoko, Minamizaki, Tomoko, Kozai, Katsuyuki, Tanne, Kazuo, Aubin, Jane E, Maeda, Norihiko

“…Introduction: Fibroblast growth factor (FGF)23 is produced primarily in bone and acts on kidney as a systemic phosphaturic factor; high levels result in…”
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The dynamics of DNA methylation and hydroxymethylation during amelogenesis by Yoshioka, Hirotaka, Minamizaki, Tomoko, Yoshiko, Yuji

“…Amelogenesis is a multistep process that relies on specific temporal and spatial signaling networks between the dental epithelium and mesenchymal tissues…”
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The bioactive acidic serine- and aspartate-rich motif peptide by Minamizaki, Tomoko, Yoshiko, Yuji

“…The organic component of the bone matrix comprises 40% dry weight of bone. The organic component is mostly composed of type I collagen and small amounts of…”
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Mineralized tissue cells are a principal source of FGF23 by Yoshiko, Yuji, Wang, Hua, Minamizaki, Tomoko, Ijuin, Chise, Yamamoto, Ryoko, Suemune, Setsuko, Kozai, Katsuyuki, Tanne, Kazuo, Aubin, Jane E, Maeda, Norihiko

“…Abstract While fibroblast growth factor (FGF) 23 is known as a phosphaturic factor in inherited and/or acquired hypophosphatemic disorders, it also serves an…”
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Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation by Ito, Shota, Minamizaki, Tomoko, Kohno, Shohei, Sotomaru, Yusuke, Kitaura, Yoshiaki, Ohba, Shinsuke, Sugiyama, Toshie, Aubin, Jane E., Tanimoto, Kotaro, Yoshiko, Yuji

“…We recently reported an unexpected role of osteoblast-derived matrix vesicles in the delivery of microRNAs to bone matrix. Of such microRNAs, we found that…”
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EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures by Minamizaki, Tomoko, Yoshiko, Yuji, Kozai, Katsuyuki, Aubin, Jane E, Maeda, Norihiko

“…Abstract Of the four prostaglandin (PG) E receptor subtypes (EP1–EP4), EP2 and EP4 have been proposed to mediate the anabolic action of PGE2 on bone formation…”
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Developmental impairments of craniofacial bone and cartilage in transgenic mice expressing FGF10 by Yoshioka, Hirotaka, Kagawa, Kazuko, Minamizaki, Tomoko, Nakano, Masashi, Aubin, Jane E., Kozai, Katsuyuki, Tsuga, Kazuhiro, Yoshiko, Yuji

“…Mutations in a common extracellular domain of fibroblast growth factor receptor (FGFR)-2 isoforms (type IIIb and IIIc) cause craniosynostosis syndrome and…”
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The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice by Minamizaki, Tomoko, Nakao, Yuko, Irie, Yasumasa, Ahmed, Faisal, Itoh, Shota, Sarmin, Nushrat, Yoshioka, Hirotaka, Nobukiyo, Asako, Fujimoto, Chise, Niida, Shumpei, Sotomaru, Yusuke, Tanimoto, Kotaro, Kozai, Katsuyuki, Sugiyama, Toshie, Bonnelye, Edith, Takei, Yuichiro, Yoshiko, Yuji

“…Communication between osteoblasts and osteoclasts plays a key role in bone metabolism. We describe here an unexpected role for matrix vesicles (MVs), which bud…”
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Single‐Cell RNA‐Sequencing Reveals the Breadth of Osteoblast Heterogeneity by Yoshioka, Hirotaka, Okita, Saki, Nakano, Masashi, Minamizaki, Tomoko, Nubukiyo, Asako, Sotomaru, Yusuke, Bonnelye, Edith, Kozai, Katsuyuki, Tanimoto, Kotaro, Aubin, Jane E, Yoshiko, Yuji

“…ABSTRACT The current paradigm of osteoblast fate is that the majority undergo apoptosis, while some further differentiate into osteocytes and others flatten…”
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1α,25-dihydroxyvitamin D3 acts predominately in mature osteoblasts under conditions of high extracellular phosphate to increase fibroblast growth factor 23 production in vitro by Yamamoto, Ryoko, Minamizaki, Tomoko, Yoshiko, Yuji, Yoshioka, Hirotaka, Tanne, Kazuo, Aubin, Jane E, Maeda, Norihiko

“…Osteoblasts/osteocytes are the principle sources of fibroblast growth factor 23 (FGF23), a phosphaturic hormone, but the regulation of FGF23 expression during…”
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Comparative proteome analysis of wild‐type and klotho‐knockout mouse kidneys using a combination of MALDI‐IMS and LC‐MS/MS by Fujino, Yoko, Minamizaki, Tomoko, Hayashi, Ikue, Kawakami, Asako, Miyaji, Takaaki, Sakurai, Kaoru, Yoshioka, Hirotaka, Kozai, Katsuyuki, Okada, Mitsugi, Yoshiko, Yuji

“…Purpose Mutation of the klotho gene in mice elicits a syndrome resembling accelerated human aging. However, there is limited evidence for the role of Klotho in…”
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Incisor Enamel Formation is Impaired in Transgenic Rats Overexpressing the Type III NaPi Transporter Slc20a1 by Yoshioka, Hirotaka, Yoshiko, Yuji, Minamizaki, Tomoko, Suzuki, Sayaka, Koma, Yoshiro, Nobukiyo, Asako, Sotomaru, Yusuke, Suzuki, Atsushi, Itoh, Mitsuyasu, Maeda, Norihiko

“…Inorganic phosphate (Pi) is required in many biological processes, including signaling cascades, skeletal development, tooth mineralization, and nucleic acid…”
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Imaging and mapping of mouse bone using MALDI-imaging mass spectrometry by Fujino, Yoko, Minamizaki, Tomoko, Yoshioka, Hirotaka, Okada, Mitsugi, Yoshiko, Yuji

“…Matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS) is an advanced method used globally to analyze the distribution of…”
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A subset of osteoblasts expressing high endogenous levels of PPARgamma switches fate to adipocytes in the rat calvaria cell culture model by Yoshiko, Yuji, Oizumi, Kiyoshi, Hasegawa, Takuro, Minamizaki, Tomoko, Tanne, Kazuo, Maeda, Norihiko, Aubin, Jane E

“…Understanding fate choice and fate switching between the osteoblast lineage (ObL) and adipocyte lineage (AdL) is important to understand both the developmental…”
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Large scale analysis of osteocyte lacunae in klotho hypomorphic mice using high-resolution micro-computed tomography by Ahmed, Faisal, Minamizaki, Tomoko, Aubin, Jane E., Damayanti, Merry Annisa, Yoshiko, Yuji

“…Osteocytes are the most abundant cell type in adult bone, and the morphological characteristics of osteocytes and their lacunae appear to influence bone mass…”
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2,3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells by Kharaghani, Davood, Kohno, Shohei, Minamizaki, Tomoko, Hoshino, Tomonori, Yoshiko, Yuji

“…Anionic polyphosphate compounds are well-known to inhibit the formation of hydroxyapatite crystals. Vascular calcification (VC) is associated with an increase…”
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