Search Results - "Minamishima, Yohji A."

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway by Lee, Sam W, Ohtsuka, Takao, Ryu, Hoon, Minamishima, Yohji A, Macip, Salvador, Sagara, Junji, Nakayama, Keiichi I, Aaronson, Stuart A

“…The apoptosis-associated speck-like protein (ASC) is an unusual adaptor protein that contains the Pyrin/PAAD death domain in addition to the CARD…”
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BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition by Ouchi, Mutsuko, Fujiuchi, Nobuko, Sasai, Kaori, Katayama, Hiroshi, Minamishima, Yohji A, Ongusaha, Pat P, Deng, Chuxia, Sen, Subrata, Lee, Sam W, Ouchi, Toru

“…Aurora-A/BTAK/STK15 localizes to the centrosome in the G 2 -M phase, and its kinase activity regulates the G 2 to M transition of the cell cycle. Previous…”
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Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation by OHTSUKA, Takao, HOON RYU, MINAMISHIMA, Yohji A, RYO, Akihide, LEE, Sam W

“…Cyclin G is a transcriptional target gene of tumor suppressor p53. Recent studies present evidence that cyclin G may play a central role in the p53-Mdm2…”
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A possible role for centrosome overduplication in radiation-induced cell death by SATO, Norihiro, MIZUMOTO, Kazuhiro, NAKAMURA, Masafumi, UENO, Hikaru, MINAMISHIMA, Yohji A, FARBER, John L, TANAKA, Masao

“…Radiotherapy plays a key role in the treatment of many tumors; however, the precise mechanisms responsible for radiation-induced cell death remain uncertain…”
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Skp2-Mediated Degradation of p27 Regulates Progression into Mitosis by Nakayama, Keiko, Nagahama, Hiroyasu, Minamishima, Yohji A, Miyake, Satoshi, Ishida, Noriko, Hatakeyama, Shigetsugu, Kitagawa, Masatoshi, Iemura, Shun-ichiro, Natsume, Tohru, Nakayama, Keiichi I

“…Although Skp2 has been thought to mediate the degradation of p27 at the G 1-S transition, Skp2 −/− cells exhibit accumulation of p27 in S-G 2 phase with…”
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Tumor Suppression through Angiogenesis Inhibition by SUIT-2 Pancreatic Cancer Cells Genetically Engineered to Secrete NK4 by SAIMURA, Michiyo, NAGAI, Eishi, MIZUMOTO, Kazuhiro, MAEHARA, Naoki, MINAMISHIMA, Yohji A, KATANO, Mitsuo, MATSUMOTO, Kunio, NAKAMURA, Toshikazu, TANAKA, Masao

“…NK4, composed of the N-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts not only as a competitive antagonist of HGF…”
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Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice by Takai, H, Tominaga, K, Motoyama, N, Minamishima, Y A, Nagahama, H, Tsukiyama, T, Ikeda, K, Nakayama, K, Nakanishi, M

“…The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1…”
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Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice by MINAMISHIMA, Yohji A, NAKAYAMA, Keiko, NAKAYAMA, Kei-Ichi

“…The abundance of p27(Kip1), an inhibitor of cell proliferation, is determined by Skp2-dependent proteolysis, the deregulation of which is associated with…”
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Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells by Sato, Norihiro, Mizumoto, Kazuhiro, Nakamura, Masafumi, Maehara, Naoki, Minamishima, Yohji A, Nishio, Shoko, Nagai, Eishi, Tanaka, Masao

“…Chromosomal instability, characterized by abnormal numbers or structures of chromosomes, is a common feature of human cancers, but the mechanisms behind these…”
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Effect of serum depletion on centrosome overduplication and death of human pancreatic cancer cells after exposure to radiation by Shono, Masaki, Sato, Norihiro, Mizumoto, Kazuhiro, Minamishima, Yohji A., Nakamura, Masafumi, Maehara, Naoki, Urashima, Taro, Saimura, Michiyo, Qian, Liwu, Nishio, Shoko, Nagai, Eishi, Tanaka, Masao

“…The tumor microenvironment is one of the key factors affecting the cellular response to radiation; however, the influence of serum concentration on tumor…”
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Down-Regulation of p27Kip1 Expression Is Required for Development and Function of T Cells by Tsukiyama, Tadasuke, Ishida, Noriko, Shirane, Michiko, Minamishima, Yohji A, Hatakeyama, Shigetsugu, Kitagawa, Masatoshi, Nakayama, Keiko, Nakayama, Kei-ichi

“…The proliferation of T cells is regulated in a development-dependent manner, but it has been unclear whether proliferation is essential for T cell…”
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Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication by Nakayama, Keiko, Nagahama, Hiroyasu, Minamishima, Yohji A., Matsumoto, Masaki, Nakamichi, Ikuo, Kitagawa, Kyoko, Shirane, Michiko, Tsunematsu, Ryosuke, Tsukiyama, Tadasuke, Ishida, Noriko, Kitagawa, Masatoshi, Nakayama, Kei-ichi, Hatakeyama, Shigetsugu

“…The ubiquitin–proteasome pathway plays an important role in control of the abundance of cell cycle regulators. Mice lacking Skp2, an F‐box protein and…”
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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication by Nakayama, K, Nagahama, H, Minamishima, Y A, Matsumoto, M, Nakamichi, I, Kitagawa, K, Shirane, M, Tsunematsu, R, Tsukiyama, T, Ishida, N, Kitagawa, M, Nakayama, K, Hatakeyama, S

“…The ubiquitin-proteasome pathway plays an important role in control of the abundance of cell cycle regulators. Mice lacking Skp2, an F-box protein and…”
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BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition by Ouchi, Mutsuko, Fujiuchi, Nobuko, Sasai, Kaori, Katayama, Hiroshi, Minamishima, Yohji A., Ongusaha, Pat P., Deng, Chuxia, Sen, Subrata, Lee, Sam W., Ouchi, Toru

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27 Kip1 , polyploidy and centrosome overduplication by Tsukiyama, Tadasuke, Shirane, Michiko, Ishida, Noriko, Nakayama, Kei-ichi, Nakayama, Keiko, Nakamichi, Ikuo, Kitagawa, Kyoko, Minamishima, Yohji A, Tsunematsu, Ryosuke, Matsumoto, Masaki, Kitagawa, Masatoshi, Hatakeyama, Shigetsugu, Nagahama, Hiroyasu

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