Search Results - "Minamimoto, Takafumi"

Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease by Watanabe, Satoshi, Kurotani, Tohru, Oga, Tomofumi, Noguchi, Jun, Isoda, Risa, Nakagami, Akiko, Sakai, Kazuhisa, Nakagaki, Keiko, Sumida, Kayo, Hoshino, Kohei, Saito, Koichi, Miyawaki, Izuru, Sekiguchi, Masayuki, Wada, Keiji, Minamimoto, Takafumi, Ichinohe, Noritaka

“…Autism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and gene expression changes. Early intervention during childhood is…”
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Chronic Behavioral Manipulation via Orally Delivered Chemogenetic Actuator in Macaques by Oyama, Kei, Hori, Yukiko, Nagai, Yuji, Miyakawa, Naohisa, Mimura, Koki, Hirabayashi, Toshiyuki, Inoue, Ken-Ichi, Takada, Masahiko, Higuchi, Makoto, Minamimoto, Takafumi

“…The chemogenetic technology referred to as designer receptors exclusively activated by designer drugs (DREADDs) offers reversible means to control neuronal…”
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Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys by Nagai, Yuji, Miyakawa, Naohisa, Takuwa, Hiroyuki, Hori, Yukiko, Oyama, Kei, Ji, Bin, Takahashi, Manami, Huang, Xi-Ping, Slocum, Samuel T., DiBerto, Jeffrey F., Xiong, Yan, Urushihata, Takuya, Hirabayashi, Toshiyuki, Fujimoto, Atsushi, Mimura, Koki, English, Justin G., Liu, Jing, Inoue, Ken-ichi, Kumata, Katsushi, Seki, Chie, Ono, Maiko, Shimojo, Masafumi, Zhang, Ming-Rong, Tomita, Yutaka, Nakahara, Jin, Suhara, Tetsuya, Takada, Masahiko, Higuchi, Makoto, Jin, Jian, Roth, Bryan L., Minamimoto, Takafumi

“…The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling,…”
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Effects of a 5-HT4 receptor antagonist in the caudate nucleus on the performance of macaques in a delayed reward task by Hori, Yukiko, Iwaoki, Haruhiko, Mimura, Koki, Nagai, Yuji, Higuchi, Makoto, Minamimoto, Takafumi

“…Temporal discounting, in which the recipient of a reward perceives the value of that reward to decrease with delay in its receipt, is associated with…”
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Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates by MINAMIMOTO, Takafumi, NAGAI, Yuji, OYAMA, Kei

“…Nonhuman primates, particularly macaque and marmoset monkeys, serve as invaluable models for studying complex brain functions and behavior. However, the lack…”
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Macaques Exhibit Implicit Gaze Bias Anticipating Others’ False-Belief-Driven Actions via Medial Prefrontal Cortex by Hayashi, Taketsugu, Akikawa, Ryota, Kawasaki, Keisuke, Egawa, Jun, Minamimoto, Takafumi, Kobayashi, Kazuto, Kato, Shigeki, Hori, Yukiko, Nagai, Yuji, Iijima, Atsuhiko, Someya, Toshiyuki, Hasegawa, Isao

“…The ability to infer others’ mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false…”
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D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys by Hori, Yukiko, Nagai, Yuji, Mimura, Koki, Suhara, Tetsuya, Higuchi, Makoto, Bouret, Sebastien, Minamimoto, Takafumi

“…It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D 1 -like receptor (D 1 R)…”
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Single caudate neurons encode temporally discounted value for formulating motivation for action by Hori, Yukiko, Mimura, Koki, Nagai, Yuji, Fujimoto, Atsushi, Oyama, Kei, Kikuchi, Erika, Inoue, Ken-Ichi, Takada, Masahiko, Suhara, Tetsuya, Richmond, Barry J, Minamimoto, Takafumi

“…The term 'temporal discounting' describes both choice preferences and motivation for delayed rewards. Here we show that neuronal activity in the dorsal part of…”
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Trait and State-Dependent Risk Attitude of Monkeys Measured in a Single-Option Response Task by Fujimoto, Atsushi, Minamimoto, Takafumi

“…Humans and animals show diverse preferences for risks ("trait-like" risk attitude) and shift their preference depending on the state or current needs…”
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[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain by Yan, Xuefeng, Telu, Sanjay, Dick, Rachel M, Liow, Jeih-San, Zanotti-Fregonara, Paolo, Morse, Cheryl L, Manly, Lester S, Gladding, Robert L, Shrestha, Stal, Lerchner, Walter, Nagai, Yuji, Minamimoto, Takafumi, Zoghbi, Sami S, Innis, Robert B, Pike, Victor W, Richmond, Barry J, Eldridge, Mark AG

“…Previous work found that [11C]deschloroclozapine ([11C]DCZ) is superior to [11C]clozapine ([11C]CLZ) for imaging Designer Receptors Exclusively Activated by…”
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Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events by Yamanaka, Ko, Hori, Yukiko, Minamimoto, Takafumi, Yamada, Hiroshi, Matsumoto, Naoyuki, Enomoto, Kazuki, Aosaki, Toshihiko, Graybiel, Ann M., Kimura, Minoru

“…The thalamus provides a massive input to the striatum, but despite accumulating evidence, the functions of this system remain unclear. It is known, however,…”
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Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value by Eldridge, Mark A G, Lerchner, Walter, Saunders, Richard C, Kaneko, Hiroyuki, Krausz, Kristopher W, Gonzalez, Frank J, Ji, Bin, Higuchi, Makoto, Minamimoto, Takafumi, Richmond, Barry J

“…The authors used a reversible inactivation technique that has not been used before in Old World monkeys, inhibitory chemogenetic receptors (DREADDs), to…”
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Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network by Hirabayashi, Toshiyuki, Nagai, Yuji, Hori, Yukiko, Inoue, Ken-ichi, Aoki, Ichio, Takada, Masahiko, Suhara, Tetsuya, Higuchi, Makoto, Minamimoto, Takafumi

“…Concurrent genetic neuromodulation and functional magnetic resonance imaging (fMRI) in primates has provided a valuable opportunity to assess the modified…”
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PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey by Zhou, Xiaoyun, Ji, Bin, Seki, Chie, Nagai, Yuji, Minamimoto, Takafumi, Fujinaga, Masayuki, Zhang, Ming-Rong, Saito, Takashi, Saido, Takaomi C, Suhara, Tetsuya, Kimura, Yasuyuki, Higuchi, Makoto

“…Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this study, we developed a novel PET radioligand for CSF1R, 11C-GW2580,…”
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Segmented Iba1-Positive Processes of Microglia in Autism Model Marmosets by Sanagi, Tomomi, Sasaki, Tetsuya, Nakagaki, Keiko, Minamimoto, Takafumi, Kohsaka, Shinichi, Ichinohe, Noritaka

“…Autism spectrum disorder (ASD) is one of the most widespread neurodevelopmental disorders, characterized by impairment in social interactions, and restricted…”
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A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains by Shimojo, Masafumi, Ono, Maiko, Takuwa, Hiroyuki, Mimura, Koki, Nagai, Yuji, Fujinaga, Masayuki, Kikuchi, Tatsuya, Okada, Maki, Seki, Chie, Tokunaga, Masaki, Maeda, Jun, Takado, Yuhei, Takahashi, Manami, Minamihisamatsu, Takeharu, Zhang, Ming‐Rong, Tomita, Yutaka, Suzuki, Norihiro, Maximov, Anton, Suhara, Tetsuya, Minamimoto, Takafumi, Sahara, Naruhiko, Higuchi, Makoto

“…Positron emission tomography (PET) allows biomolecular tracking but PET monitoring of brain networks has been hampered by a lack of suitable reporters. Here,…”
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Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys by Hori, Yukiko, Mimura, Koki, Nagai, Yuji, Hori, Yuki, Kumata, Katsushi, Zhang, Ming-Rong, Suhara, Tetsuya, Higuchi, Makoto, Minamimoto, Takafumi

“…Serotonin (5-HT) deficiency is a core biological pathology underlying depression and other psychiatric disorders whose key symptoms include decreased…”
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Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain by Obokata, Naoyuki, Seki, Chie, Hirata, Takeshi, Maeda, Jun, Ishii, Hideki, Nagai, Yuji, Matsumura, Takehiko, Takakuwa, Misae, Fukuda, Hajime, Minamimoto, Takafumi, Kawamura, Kazunori, Zhang, Ming-Rong, Nakajima, Tatsuo, Saijo, Takeaki, Higuchi, Makoto

“…Purpose Phosphodiesterase (PDE) 7 is a potential therapeutic target for neurological and inflammatory diseases, although in vivo visualization of PDE7 has not…”
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A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain by Kimura, Kei, Nagai, Yuji, Hatanaka, Gaku, Fang, Yang, Tanabe, Soshi, Zheng, Andi, Fujiwara, Maki, Nakano, Mayuko, Hori, Yukiko, Takeuchi, Ryosuke F., Inagaki, Mikio, Minamimoto, Takafumi, Fujita, Ichiro, Inoue, Ken-ichi, Takada, Masahiko

“…Recent emphasis has been placed on gene transduction mediated through recombinant adeno-associated virus (AAV) vector to manipulate activity of neurons and…”
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Visualization of AMPA receptors in living human brain with positron emission tomography by Miyazaki, Tomoyuki, Nakajima, Waki, Hatano, Mai, Shibata, Yusuke, Kuroki, Yoko, Arisawa, Tetsu, Serizawa, Asami, Sano, Akane, Kogami, Sayaka, Yamanoue, Tomomi, Kimura, Kimito, Hirata, Yushi, Takada, Yuuki, Ishiwata, Yoshinobu, Sonoda, Masaki, Tokunaga, Masaki, Seki, Chie, Nagai, Yuji, Minamimoto, Takafumi, Kawamura, Kazunori, Zhang, Ming-Rong, Ikegaya, Naoki, Iwasaki, Masaki, Kunii, Naoto, Kimura, Yuichi, Yamashita, Fumio, Taguri, Masataka, Tani, Hideaki, Nagai, Nobuhiro, Koizumi, Teruki, Nakajima, Shinichiro, Mimura, Masaru, Yuzaki, Michisuke, Kato, Hiroki, Higuchi, Makoto, Uchida, Hiroyuki, Takahashi, Takuya

“…Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are thought to underlie…”
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