Search Results - "Minami, S Sakura"

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss by Tracy, Tara E., Sohn, Peter Dongmin, Minami, S. Sakura, Wang, Chao, Min, Sang-Won, Li, Yaqiao, Zhou, Yungui, Le, David, Lo, Iris, Ponnusamy, Ravikumar, Cong, Xin, Schilling, Birgit, Ellerby, Lisa M., Huganir, Richard L., Gan, Li

“…Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer’s disease (AD), but the mechanism by which tau alters synapse physiology…”
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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits by Min, Sang-Won, Chen, Xu, Tracy, Tara E, Li, Yaqiao, Zhou, Yungui, Wang, Chao, Shirakawa, Kotaro, Minami, S Sakura, Defensor, Erwin, Mok, Sue Ann, Sohn, Peter Dongmin, Schilling, Birgit, Cong, Xin, Ellerby, Lisa, Gibson, Bradford W, Johnson, Jeffrey, Krogan, Nevan, Shamloo, Mehrdad, Gestwicki, Jason, Masliah, Eliezer, Verdin, Eric, Gan, Li

“…Acetylation of tau at K174 is identified in Alzheimer's disease (AD) brain tissue and exacerbates tau-mediated neurodegeneration and memory impairments in…”
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Cyclooxygenase‐1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease by Choi, Sang‐Ho, Aid, Saba, Caracciolo, Luca, Sakura Minami, S., Niikura, Takako, Matsuoka, Yasuji, Turner, R. Scott, Mattson, Mark P., Bosetti, Francesca

“…Several epidemiological and preclinical studies suggest that non‐steroidal anti‐inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX), reduce the…”
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Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model by Hirata-Fukae, Chiho, Li, Hui-Fang, Hoe, Hyang-Sook, Gray, Audrey J, Minami, S. Sakura, Hamada, Katsuyoshi, Niikura, Takako, Hua, Fang, Tsukagoshi-Nagai, Hiroe, Horikoshi-Sakuraba, Yuko, Mughal, Mohamed, Rebeck, G. William, LaFerla, Frank M, Mattson, Mark P, Iwata, Nobuhisa, Saido, Takaomi C, Klein, William L, Duff, Karen E, Aisen, Paul S, Matsuoka, Yasuji

“…Abstract Epidemiological studies indicate that women have a higher risk of Alzheimer's disease (AD) even after adjustment for age. Though transgenic mouse…”
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Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage by Matsuoka, Yasuji, Gray, Audrey J, Hirata-Fukae, Chiho, Minami, S Sakura, Waterhouse, Emily Graeme, Mattson, Mark P, LaFerla, Frank M, Gozes, Illana, Aisen, Paul S

“…Accumulation of beta-amyloid (Abeta) peptide and hyperphosphorylation of tau in the brain are pathological hallmarks of Alzheimer's disease (AD). Agents…”
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Selective targeting of microglia by quantum dots by Minami, S Sakura, Sun, Binggui, Popat, Ketul, Kauppinen, Tiina, Pleiss, Mike, Zhou, Yungui, Ward, Michael E, Floreancig, Paul, Mucke, Lennart, Desai, Tejal, Gan, Li

“…Microglia, the resident immune cells of the brain, have been implicated in brain injury and various neurological disorders. However, their precise roles in…”
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Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice by Britton, Rachel, Liu, Angela T., Rege, Sanket V., Adams, Julia M., Akrapongpisak, Lily, Le, David, Alcantara‐Lee, Raniel, Estrada, Raul A., Ray, Rebecca, Ahadi, Sara, Gallager, Ian, Yang, Cindy F., Minami, S. Sakura, Braithwaite, Steven P., Czirr, Eva, Campbell, Meghan Kerrisk

“…Introduction Increasing age is the number one risk factor for developing cognitive decline and neurodegenerative disease. Aged humans and mice exhibit numerous…”
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CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain by Rege, Sanket V., Teichert, Arnaud, Masumi, Juliet, Dhande, Onkar S., Harish, Reema, Higgins, Brett W., Lopez, Yesenia, Akrapongpisak, Lily, Hackbart, Hannah, Caryotakis, Sofia, Leone, Dino P., Szoke, Balazs, Hannestad, Jonas, Nikolich, Karoly, Braithwaite, Steven P., Minami, S. Sakura

“…Targeting immune-mediated, age-related, biology has the potential to be a transformative therapeutic strategy. However, the redundant nature of the multiple…”
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Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent‐resistant membranes by Minami, S. Sakura, Hoe, Hyang‐Sook, Rebeck, G. William

“…J. Neurochem. (2011) 118, 879–890. The adaptor protein Disabled1 (Dab1) interacts with amyloid precursor protein (APP) and decreases its pathological…”
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Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice by Babus, Lenard W, Little, Elizabeth M, Keenoy, Kathleen E, Minami, S. Sakura, Chen, Eric, Song, Jung Min, Caviness, Juliet, Koo, So-Yeon, Pak, Daniel T.S, Rebeck, G. William, Turner, R. Scott, Hoe, Hyang-Sook

“…Abstract Fyn is a Src-family tyrosine kinase that affects long term potentiation (LTP), synapse formation, and learning and memory. Fyn is also implicated in…”
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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice by NISHITOMI, Kouhei, SAKAGUCHI, Gaku, NAKAJIMA, Yoshihiro, LI, Hui-Fang, TAKEYAMA, Chie, KIHARA, Tsuyoshi, OTA, Akinobu, WONG, Philip C, AISEN, Paul S, KATO, Akira, KINOSHITA, Noriaki, MATSUOKA, Yasuji, HORIKOSHI, Yuko, GRAY, Audrey J, MAEDA, Masahiro, HIRATA-FUKAE, Chiho, BECKER, Amanda G, HOSONO, Motoko, SAKAGUCHI, Isako, SAKURA MINAMI, S

“…Accumulation of amyloid beta peptide (Abeta) in brain is a hallmark of Alzheimer's disease (AD). Inhibition of beta-site amyloid precursor protein…”
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Fyn Modulation of Dab1 Effects on Amyloid Precursor Protein and ApoE Receptor 2 Processing by Hoe, Hyang-Sook, Minami, S. Sakura, Makarova, Alexandra, Lee, Jiyeon, Hyman, Bradley T., Matsuoka, Yasuji, Rebeck, G. William

“…Dab1 is an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2), increases their levels on the cell…”
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Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models by Minami, S Sakura, Min, Sang-Won, Krabbe, Grietje, Wang, Chao, Zhou, Yungui, Asgarov, Rustam, Li, Yaqiao, Martens, Lauren H, Elia, Lisa P, Ward, Michael E, Mucke, Lennart, Farese, Robert V, Gan, Li

“…Progranulin overexpression in Alzheimer's disease model mice protects against neuronal loss and enhances cognitive deficits. Haploinsufficiency of the…”
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Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis by Ward, Michael E, Chen, Robert, Huang, Hsin-Yi, Ludwig, Connor, Telpoukhovskaia, Maria, Taubes, Ali, Boudin, Helene, Minami, Sakura S, Reichert, Meredith, Albrecht, Philipp, Gelfand, Jeffrey M, Cruz-Herranz, Andres, Cordano, Christian, Alavi, Marcel V, Leslie, Shannon, Seeley, William W, Miller, Bruce L, Bigio, Eileen, Mesulam, Marek-Marsel, Bogyo, Matthew S, Mackenzie, Ian R, Staropoli, John F, Cotman, Susan L, Huang, Eric J, Gan, Li, Green, Ari J

“…Heterozygous mutations in the gene lead to progranulin (PGRN) haploinsufficiency and cause frontotemporal dementia (FTD), a neurodegenerative syndrome of older…”
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Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease by Minami, S Sakura, Sidahmed, Elkhansa, Aid, Saba, Shimoji, Mika, Niikura, Takako, Mocchetti, Italo, Rebeck, G William, Prendergast, Jay S, Dealwis, Chris, Wetzel, Ronald, Bosetti, Francesca, Matsuoka, Yasuji, Hoe, Hyang-Sook, Turner, R Scott

“…Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease…”
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Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia by Krabbe, Grietje, Minami, S. Sakura, Etchegaray, Jon I., Taneja, Praveen, Djukic, Biljana, Davalos, Dimitrios, Le, David, Lo, Iris, Zhan, Lihong, Reichert, Meredith C., Sayed, Faten, Merlini, Mario, Ward, Michael E., Perry, David C., Lee, Suzee E., Sias, Ana, Parkhurst, Christopher N., Gan, Wen-biao, Akassoglou, Katerina, Miller, Bruce L., Farese, Robert V., Gan, Li

“…Frontotemporal dementia (FTD) is the second most common dementia before 65 years of age. Haploinsufficiency in the progranulin (GRN) gene accounts for 10% of…”
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ApoE mimetic peptide decreases Aβ production in vitro and in vivo by Minami, S Sakura, Cordova, Antoinette, Cirrito, John R, Tesoriero, Joseph A, Babus, Lenard W, Davis, Gary C, Dakshanamurthy, Sivanesan, Turner, R Scott, Pak, Daniel TS, Rebeck, G William, Paige, Mikell, Hoe, Hyang-Sook

“…Apolipoprotein E (apoE) is postulated to affect brain A beta levels through multiple mechanisms--by altering amyloid precursor protein (APP) processing, A beta…”
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Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists by Minami, S. Sakura, Shen, Vivian, Le, David, Krabbe, Grietje, Asgarov, Rustam, Perez-Celajes, Liberty, Lee, Chih-Hung, Li, Jinhe, Donnelly-Roberts, Diana, Gan, Li

“…[Display omitted] Mutations in the progranulin gene cause frontotemporal dementia (FTD), a debilitating neurodegenerative disease that involves atrophy of the…”
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Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice by Minami, S. Sakura, Clifford, Thomas G, Hoe, Hyang-Sook, Matsuoka, Yasuji, Rebeck, G. William

“…Abstract Fyn kinase phosphorylates tau and exacerbates amyloid beta (Aβ)-mediated synaptic dysfunction. However, Fyn also increases the nonpathological…”
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ApoE mimetic peptide decreases A[beta] production in vitro and in vivo by Minami, S Sakura, Cordova, Antoinette, Cirrito, John R, Tesoriero, Joseph A, Babus, Lenard W, Davis, Gary C, Dakshanamurthy, Sivanesan, Turner, R Scott, Pak, Daniel TS, Rebeck, G William, Paige, Mikell, Hoe, Hyang-Sook

“…Background Apolipoprotein E (apoE) is postulated to affect brain A[beta] levels through multiple mechanisms--by altering amyloid precursor protein (APP)…”
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