Search Results - "Min, Kyoung Jin"

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy by Seo, Seung Un, Woo, Seon Min, Lee, Hyun-Shik, Kim, Sang Hyun, Min, Kyoung-jin, Kwon, Taeg Kyu

“…mTOR is an important regulator of cell growth and forms two complexes, mTORC1/2. In cancer, mTOR signaling is highly activated, and the regulation of this…”
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Melatonin induces apoptotic cell death through Bim stabilization by Sp1‐mediated OTUD1 upregulation by Woo, Seon Min, Seo, Seung Un, Min, Kyoung‐jin, Kwon, Taeg Kyu

“…Melatonin, secreted by the pineal gland, regulates the circadian rhythms and also plays an oncostatic role in cancer cells. Previously, we showed that…”
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Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability by Seo, Bo Ram, Min, Kyoung-Jin, Cho, Il Je, Kim, Sang Chan, Kwon, Taeg Kyu

“…The PI3K/Akt and mTOR signaling pathways are important for cell survival and growth, and they are highly activated in cancer cells compared with normal cells…”
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Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells by Woo, Seon Min, Min, Kyoung-jin, Kwon, Taeg Kyu

“…Melatonin is involved in many physiological functions, and it has differential effects on apoptosis in normal and cancer cells. However, the mechanism of its…”
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Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells by Woo, Seon Min, Min, Kyoung-Jin, Kwon, Taeg Kyu

“…Magnolol is a biologically active compound, isolated from the Chinese herb , that regulates antiproliferative, anticancer, antiangiogenic and antimetastatic…”
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Corosolic Acid Induces Non-Apoptotic Cell Death through Generation of Lipid Reactive Oxygen Species Production in Human Renal Carcinoma Caki Cells by Woo, Seon Min, Seo, Seung Un, Min, Kyoung-Jin, Im, Seung-Soon, Nam, Ju-Ock, Chang, Jong-Soo, Kim, Shin, Park, Jong-Wook, Kwon, Taeg Kyu

“…Corosolic acid is one of the pentacyclic triterpenoids isolated from and has been reported to exhibit anti-cancer and anti-proliferative activities in various…”
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Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells by Min, Kyoung-Jin, Nam, Ju-Ock, Kwon, Taeg Kyu

“…Fisetin is a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions. Since fisetin can elicit anti-cancer effects,…”
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Hispidulin Inhibits Mast Cell-Mediated Allergic Inflammation through Down-Regulation of Histamine Release and Inflammatory Cytokines by Kim, Dong Eun, Min, Kyoung-Jin, Kim, Min-Jong, Kim, Sang-Hyun, Kwon, Taeg Kyu

“…Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a natural compound derived from traditional Chinese medicinal herbs, and it is known to have an…”
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Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells by Min, Kyoung-jin, Kwon, Taeg Kyu

“…FTY720, a sphingosine-1-phosphate (S1P) receptor modulator, is a synthetic compound produced by the modification of a metabolite from I. sinclairii. Here, we…”
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Premature ventricular contraction increases the risk of heart failure and ventricular tachyarrhythmia by Kim, Yun Gi, Choi, Yun Young, Han, Kyung-Do, Min, Kyoung Jin, Choi, Ha Young, Shim, Jaemin, Choi, Jong-Il, Kim, Young-Hoon

“…Premature ventricular contraction (PVC), a common arrhythmia affecting 1–2% of the general population, has been considered to have a benign clinical course…”
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Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression by Woo, Seon Min, Min, Kyoung-Jin, Kwon, Taeg Kyu

“…Mitochondrial fragmentation occurs during the apoptosis. Dynamin-related protein 1 (Drp1) acts as an important component in mitochondrial fission machinery and…”
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Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo by Seo, Seung Un, Woo, Seon Min, Kim, Shin, Park, Jong-Wook, Lee, Hyun-Shik, Bae, Young-Seuk, Kim, Sang Hyun, Im, Seung-Soon, Seo, Ji Hae, Min, Kyoung-jin, Kwon, Taeg Kyu

“…Cathepsin K is highly expressed in various types of cancers. However, the effect of cathepsin K inhibition in cancer cells is not well characterized. Here,…”
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Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells by Seo, Seung Un, Woo, Seon Min, Im, Seung-Soon, Jang, Younghoon, Han, Eugene, Kim, Sang Hyun, Lee, Hongchan, Lee, Hyun-Shik, Nam, Ju-Ock, Gabrielson, Edward, Min, Kyoung-jin, Kwon, Taeg Kyu

“…Cathepsin D (Cat D) is well known for its roles in metastasis, angiogenesis, proliferation, and carcinogenesis in cancer. Despite Cat D being a promising…”
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Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells by Shahriyar, Sk Abrar, Woo, Seon Min, Seo, Seung Un, Min, Kyoung-Jin, Kwon, Taeg Kyu

“…Cepharanthine (CEP) is a natural plant alkaloid, and has anti-inflammatory, antineoplastic, antioxidative and anticancer properties. In this study, we…”
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Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress by Seo, Seung Un, Min, Kyoung-jin, Woo, Seon Min, Kwon, Taeg Kyu

“…Multiple cancer cells highly express cathepsin S, which has pro-tumoral effects. However, it was previously unknown whether knockdown or a pharmacological…”
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Elucidation for modulation of death receptor (DR) 5 to strengthen apoptotic signals in cancer cells by Min, Kyoung-jin, Woo, Seon Min, Shahriyar, Sk Abrar, Kwon, Taeg Kyu

“…The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis via death receptor (DR) 4 or DR5 preferentially in cancer cells,…”
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Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma by Woo, Seon Min, Min, Kyoung-Jin, Seo, Seung Un, Kim, Shin, Kubatka, Peter, Park, Jong-Wook, Kwon, Taeg Kyu

“…R428, a selective small molecule Axl inhibitor, is known to have anti-cancer effects, such as inhibition of invasion and proliferation and induction of cell…”
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Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells by Um, Hee Jung, Min, Kyoung-jin, Kim, Dong Eun, Kwon, Taeg Kyu

“…► Withaferin A inhibits both the constitutive and inducible STAT3 activation. ► Withaferin A effectively inhibits JAK2 phosphorylation. ► Withaferin A…”
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Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-κB and STAT/GAS activity by Min, Kyoung-Jin, Jang, Ji Hoon, Kwon, Taeg Kyu

“…:  Melatonin influences sleep and circadian rhythm, and it has anti‐inflammatory functions. However, the mechanism of its anti‐inflammatory roles is not well…”
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Itch and autophagy-mediated NF-κB activation contributes to inhibition of cathepsin D-induced sensitizing effect on anticancer drugs by Seo, Seung Un, Woo, Seon Min, Min, Kyoung-jin, Kwon, Taeg Kyu

“…Inhibition of cathepsin D (Cat D) sensitizes cancer cells to anticancer drugs via RNF183-mediated downregulation of Bcl-xL expression. Although NF-κB…”
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