Search Results - "Milton Ozório Moraes"

Leprosy incidence and risk estimates in a 33-year contact cohort of leprosy patients by Hacker, Mariana Andrea, Sales, Anna Maria, Duppre, Nádia Cristina, Sarno, Euzenir Nunes, Moraes, Milton Ozório

“…Reduction in incidence has been associated with the introduction of novel approaches, like chemo/immune-prophylaxis. Incidence determined through follow-up…”
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PCR-based techniques for leprosy diagnosis: from the laboratory to the clinic by Martinez, Alejandra Nóbrega, Talhari, Carolina, Moraes, Milton Ozório, Talhari, Sinésio

“…In leprosy, classic diagnostic tools based on bacillary counts and histopathology have been facing hurdles, especially in distinguishing latent infection from…”
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Validation of the performance of a point of care molecular test for leprosy: From a simplified DNA extraction protocol to a portable qPCR by Bertão-Santos, Amanda, Dias, Larisse da Silva, Ribeiro-Alves, Marcelo, Pinheiro, Roberta Olmo, Moraes, Milton Ozório, Manta, Fernanda Saloum de Neves, Costa, Alexandre Dias Tavares

“…The study aimed to optimize qPCR reactions using oligonucleotides from the first Brazilian molecular diagnostic kit for leprosy on a portable platform…”
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IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study by Pacheco, Antonio Guilherme, Cardoso, Cynthia Chester, Moraes, Milton Ozório

“…Susceptibility to infectious diseases is influenced by genetic background and efficient cellular immune activation is responsible for protection. In…”
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Revisiting the genetic ancestry of Brazilians using autosomal AIM-Indels by Saloum de Neves Manta, Fernanda, Pereira, Rui, Vianna, Romulo, Rodolfo Beuttenmüller de Araújo, Alfredo, Leite Góes Gitaí, Daniel, Aparecida da Silva, Dayse, de Vargas Wolfgramm, Eldamária, da Mota Pontes, Isabel, Ivan Aguiar, José, Ozório Moraes, Milton, Fagundes de Carvalho, Elizeu, Gusmão, Leonor

“…There are many different studies that contribute to the global picture of the ethnic heterogeneity in Brazilian populations. These studies use different types…”
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Leprosy post-exposure prophylaxis: innovation and precision public health by Moraes, Milton Ozório, Düppre, Nádia Cristina

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A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts by Gama, Rafael Silva, Souza, Márcio Luís Moreira de, Sarno, Euzenir Nunes, Moraes, Milton Ozório de, Gonçalves, Aline, Stefani, Mariane M A, Garcia, Raúl Marcel González, Fraga, Lucia Alves de Oliveira

“…Early detection of Mycobacterium leprae is a key strategy for disrupting the transmission chain of leprosy and preventing the potential onset of physical…”
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Reanalysis and validation of the transcriptional pleural fluid signature in pleural tuberculosis by Corrêa, Raquel da Silva, Leal-Calvo, Thyago, Mafort, Thiago Thomaz, Santos, Ana Paula, Leung, Janaína, Pinheiro, Roberta Olmo, Rufino, Rogério, Moraes, Milton Ozório, Rodrigues, Luciana Silva

“…Pleural tuberculosis (PlTB), the most common site of extrapulmonary TB, is characterized by a paucibacillary nature and a compartmentalized inflammatory…”
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Leprosy among schoolchildren in the Amazon region: A cross-sectional study of active search and possible source of infection by contact tracing by Pedrosa, Valderiza Lourenço, Dias, Luiz Claudio, Galban, Enrique, Leturiondo, André, Palheta, Jr, Jamile, Santos, Monica, Moraes, Milton Ozório, Talhari, Carolina

“…The high rate of leprosy cases among children under 15 years of age in Brazil indicates ongoing transmission within the community. The identification of the…”
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Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population by Milano, Mariana, Moraes, Milton Ozório, Rodenbusch, Rodrigo, Carvalho, Caroline Xavier, Delcroix, Melaine, Mousquer, Gabriel, Laux da Costa, Lucas, Unis, Gisela, Dalla Costa, Elis Regina, Rossetti, Maria Lucia Rosa

“…In Mycobacterium tuberculosis (MTB) infection, the complex interaction of host immune system and the mycobacteria is associated with levels of cytokines…”
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Reduction of host cell mitochondrial activity as Mycobacterium leprae’s strategy to evade host innate immunity by Oliveira, Marcus Fernandes, Medeiros, Rychelle Clayde Affonso, Mietto, Bruno Siqueira, Calvo, Thyago Leal, Mendonça, Ana Paula Miranda, Rosa, Thabatta Leal Silveira Andrezo, Silva, Débora Santos da, Vasconcelos, Karina Girardi do Carmo de, Pereira, Antonio Marcos Rodrigues, Macedo, Cristiana Santos, Pereira, Geraldo Moura Batista, Moreira, Marcia de Berrêdo Pinho, Pessolani, Maria Cristina Vidal, Moraes, Milton Ozório, Lara, FA

“…Leprosy is a much‐feared incapacitating infectious disease caused by Mycobacterium leprae or M lepromatosis, annually affecting roughly 200,000 people…”
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Development of a multivariate predictive model for dapsone adverse drug events in people with leprosy under standard WHO multidrug therapy by de Araujo, Ana Carolina Galvão Dos Santos, Hacker, Mariana de Andrea Vilas-Boas, Pinheiro, Roberta Olmo, Illarramendi, Ximena, Durães, Sandra Maria Barbosa, Nobre, Maurício Lisboa, Moraes, Milton Ozório, Sales, Anna Maria, da Silva, Gilberto Marcelo Sperandio

“…The occurrence of adverse drug events (ADEs) during dapsone (DDS) treatment in patients with leprosy can constitute a significant barrier to the successful…”
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Performance of serological tests PGL1 and NDO-LID in the diagnosis of leprosy in a reference Center in Brazil by Leturiondo, André Luiz, Noronha, Ariani Batista, do Nascimento, Monik Oney Oliveira, Ferreira, Cynthia de Oliveira, Rodrigues, Fabíola da Costa, Moraes, Milton Ozório, Talhari, Carolina

“…Early detection of leprosy and multidrug therapy are crucial to achieve zero transmission and zero grade II incapacities goals of World Health Organization…”
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Correction: Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population by Leturiondo, André Luiz, Noronha, Ariani Batista, Mendonça, Carla Yael Ribeiro, Ferreira, Cynthia de Oliveira, Alvarado-Arnez, Lucia Elena, Manta, Fernanda Saloum de Neves, Bezerra, Ohanna Cavalcanti de Lima, Carvalho, Elizeu Fagundes de, Moraes, Milton Ozório, Rodrigues, Fabíola da Costa, Talhari, Carolina

“…[This corrects the article DOI: 10.1371/journal.pntd.0008247.]…”
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Type I Interferons, Autophagy and Host Metabolism in Leprosy by Toledo Pinto, Thiago Gomes, Batista-Silva, Leonardo Ribeiro, Medeiros, Rychelle Clayde Affonso, Lara, Flávio Alves, Moraes, Milton Ozório

“…For those with leprosy, the extent of host infection by and the progression of the disease depend on the ability of mycobacteria to shape a safe environment…”
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STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival by de Toledo-Pinto, Thiago Gomes, Ferreira, Anna Beatriz Robottom, Ribeiro-Alves, Marcelo, Rodrigues, Luciana Silva, Batista-Silva, Leonardo Ribeiro, de Andrade Silva, Bruno Jorge, Lemes, Robertha Mariana Rodrigues, Martinez, Alejandra Nóbrega, Sandoval, Felipe Galvan, Alvarado-Arnez, Lucia Elena, Rosa, Patricia Sammarco, Shannon, Edward Joseph, Pessolani, Maria Cristina Vidal, Pinheiro, Roberta Olmo, Antunes, Sergio Luis Gomes, Sarno, Euzenir Nunes, Lara, Flávio Alves, Williams, Diana Lynn, Moraes, Milton Ozório

“…Cytosolic detection of nucleic acids elicits a type I interferon (IFN) response and plays a critical role in host defense against intracellular pathogens…”
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Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis by Alvarado-Arnez, Lucia Elena, Amaral, Evaldo P, Sales-Marques, Carolinne, Durães, Sandra M B, Cardoso, Cynthia C, Nunes Sarno, Euzenir, Pacheco, Antonio G, Lana, Francisco C F, Moraes, Milton Ozório

“…Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes…”
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Network analysis for science and technology management: Evidence from tuberculosis research in Fiocruz, Brazil by Fonseca, Bruna de Paula Fonseca E, Silva, Marcus Vinicius Pereira da, Araújo, Kizi Mendonça de, Sampaio, Ricardo Barros, Moraes, Milton Ozório

“…Collaborative networks are of great value for science and technology (S&T) institutions as a way of sharing, generating and disseminating new knowledge that…”
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Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction by Rosa, Thabatta Leal Silveira Andrezo, Leal-Calvo, Thyago, Tavares, Isabella Forasteiro, Mendes, Mayara Abud, Dias, André Alves, Piauy, Meire Hellen Dos Santos, Barboza, Marcella Feitosa da Silva, Kapuscinski, Marylee, Costa, Fabrício da Mota Ramalho, Marques, Maria Angela M, Belone, Andrea de Faria F, Sales, Anna Maria, Hacker, Mariana de Andrea, Moreira, Marcia de Berredo Pinho, Belisle, John T, Moraes, Milton Ozório, Pessolani, Maria Cristina Vidal, Schmitz, Veronica

“…Patients with the multibacillary form of leprosy can develop reactional episodes of acute inflammation, known as erythema nodosum leprosum (ENL), which are…”
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Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy by Sales-Marques, Carolinne, Cardoso, Cynthia Chester, Alvarado-Arnez, Lucia Elena, Illaramendi, Ximena, Sales, Anna Maria, Hacker, Mariana de Andréa, Barbosa, Mayara Garcia de Mattos, Nery, José Augusto da Costa, Pinheiro, Roberta Olmo, Sarno, Euzenir Nunes, Pacheco, Antonio Guilherme, Moraes, Milton Ozório

“…The pathways that trigger exacerbated immune reactions in leprosy could be determined by genetic variations. Here, in a prospective approach, both genetic and…”
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