Search Results - "Milsom, William K"

Do naked mole rats accumulate a metabolic acidosis or an oxygen debt in severe hypoxia? by Pamenter, Matthew E, Dzal, Yvonne A, Thompson, William A, Milsom, William K

“…In severe hypoxia, most vertebrates increase anaerobic energy production, which results in the development of a metabolic acidosis and an O debt that must be…”
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pH regulation in hibernation: Implications for ventilatory and metabolic control by Kim, Anne B., Milsom, William K.

“…Mammals in hibernation retain a relatively constant blood plasma pH (extracellular pH; pHe) that is typically alkaline relative to the pH of neutral water…”
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How bar-headed geese fly over the Himalayas by Scott, Graham R, Hawkes, Lucy A, Frappell, Peter B, Butler, Patrick J, Bishop, Charles M, Milsom, William K

“…Bar-headed geese cross the Himalayas on one of the most iconic high-altitude migrations in the world. Heart rates and metabolic costs of flight increase with…”
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Lactate provides a strong pH-independent ventilatory signal in the facultative air-breathing teleost Pangasianodon hypophthalmus by Thomsen, Mikkel T., Wang, Tobias, Milsom, William K., Bayley, Mark

“…Fish regulate ventilation primarily by sensing O 2 -levels in the water and arterial blood. It is well established that this sensory process involves several…”
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The Kölliker-Fuse nucleus orchestrates the timing of expiratory abdominal nerve bursting by Barnett, William H, Jenkin, Sarah E M, Milsom, William K, Paton, Julian F R, Abdala, Ana P, Molkov, Yaroslav I, Zoccal, Daniel B

“…Coordination of respiratory pump and valve muscle activity is essential for normal breathing. A hallmark respiratory response to hypercapnia and hypoxia is the…”
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Morphological and morphometric specializations of the lung of the Andean goose, Chloephaga melanoptera: A lifelong high-altitude resident by Maina, John N, McCracken, Kevin G, Chua, Beverly, York, Julia M, Milsom, William K

“…High altitude flight in rarefied, extremely cold and hypoxic air is a very challenging activity. Only a few species of birds can achieve it. Hitherto, the…”
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Evolution of muscle phenotype for extreme high altitude flight in the bar-headed goose by Scott, Graham R., Egginton, Stuart, Richards, Jeffrey G., Milsom, William K.

“…supply to flight muscle…”
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The trans-Himalayan flights of bar-headed geese (Anser indicus) by Hawkes, Lucy A., Balachandran, Sivananinthaperumal, Batbayar, Nyambayar, Butler, Patrick J., Frappell, Peter B., Milsom, William K., Tseveenmyadag, Natsagdorj, Newman, Scott H., Scott, Graham R., Sathiyaselvam, Ponnusamy, Takekawa, John Y., Wikelski, Martin, Bishop, Charles M.

“…Birds that fly over mountain barriers must be capable of meeting the increased energetic cost of climbing in low-density air, even though less oxygen may be…”
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Hypoxia reduces the hypothalamic thermogenic threshold and thermosensitivity by Tattersall, Glenn J., Milsom, William K.

“…Hypoxia is well known to reduce the body temperature ( T b ) of mammals, although the neural origins of this response remain uncertain. Short-term hypoxic…”
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High thermal sensitivity of blood enhances oxygen delivery in the high-flying bar-headed goose by Meir, Jessica U, Milsom, William K

“…The bar-headed goose (Anser indicus) crosses the Himalaya twice a year at altitudes where oxygen (O2) levels are less than half those at sea level and…”
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Control of breathing and adaptation to high altitude in the bar-headed goose by Scott, Graham R, Milsom, William K

“…The bar-headed goose flies over the Himalayan mountains on its migratory route between South and Central Asia, reaching altitudes of up to 9,000 m. We compared…”
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Reduced metabolism supports hypoxic flight in the high-flying bar-headed goose ( Anser indicus ) by Meir, Jessica U, York, Julia M, Chua, Bev A, Jardine, Wilhelmina, Hawkes, Lucy A, Milsom, William K

“…The bar-headed goose is famed for migratory flight at extreme altitude. To better understand the physiology underlying this remarkable behavior, we imprinted…”
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Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia by Carter, Eric A, Sheel, A William, Milsom, William K, Koehle, Michael S

“…Sildenafil is a pulmonary vasodilator that has potential to mitigate the decrement in endurance performance caused by hypoxic pulmonary vasoconstriction. The…”
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Glutamatergic Receptors Modulate Normoxic but Not Hypoxic Ventilation and Metabolism in Naked Mole Rats by Dzal, Yvonne A, Seow, Allison, Borecky, Lisa G, Chung, Danielle, Gill, Sharn K G, Milsom, William K, Pamenter, Matthew E

“…Naked mole rats ( ) are among the most hypoxia-tolerant mammals, but their physiological responses to acute and chronic sustained hypoxia (CSH), and the…”
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KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-Bötzinger Complex of Neonatal Rats in vitro by Revill, Ann L, Katzell, Alexis, Del Negro, Christopher A, Milsom, William K, Funk, Gregory D

“…The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of…”
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A comparative analysis of putative oxygen-sensing cells in the fish gill by Coolidge, Emily H, Ciuhandu, Cosima S, Milsom, William K

“…We investigated the distribution of serotonin (5-HT)-containing neuroepithelial cells (NECs), the putative O(2) sensing cells, in the gills of four species of…”
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Maximum running speed of captive bar-headed geese is unaffected by severe hypoxia by Hawkes, Lucy A, Butler, Patrick J, Frappell, Peter B, Meir, Jessica U, Milsom, William K, Scott, Graham R, Bishop, Charles M

“…While bar-headed geese are renowned for migration at high altitude over the Himalayas, previous work on captive birds suggested that these geese are unable to…”
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Flying High: A Theoretical Analysis of the Factors Limiting Exercise Performance in Birds at Altitude by Scott, Graham R, Milsom, William K

“…The ability of some bird species to fly at extreme altitude has fascinated comparative respiratory physiologists for decades, yet there is still no consensus…”
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New insights into gill chemoreception: Receptor distribution and roles in water and air breathing fish by Milsom, William K

“…Highlights ► Chemoreceptors involved in reflex cardiorespiratory responses to hypoxia and hypercarbia are variable between species. ► Their location (gills,…”
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Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia by Foster, Glen E., McKenzie, Donald C., Milsom, William K., Sheel, A. William

“…We determined the ventilatory, cardiovascular and cerebral tissue oxygen response to two protocols of normobaric, isocapnic, intermittent hypoxia. Subjects ( n…”
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