Degree and Rate of Growth Discordance in Dichorionic Twins Conceived by In Vitro Fertilization

Objective. Our objective was to estimate degree and rate of discordant growth and its impact on perinatal outcome in dichorionic twin pregnancies conceived by in vitro fertilization (IVF) compared to those conceived spontaneously. Study Design. Growth discordance was defined as 90th percentiles for...

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Bibliographic Details
Published in:	Obstetrics and Gynecology International Vol. 2014; no. 2014; pp. 167 - 172
Main Authors:	Karadzov-Orlic, Natasa T., Srbinovic, Ljubomir P., Jurisic, Aleksandar B., Milovanovic, Zagorka M., Mojovic, Donka V., Egic, Amira S., Krsmanovic, Suzana P.
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Limiteds 01-01-2014 Hindawi Publishing Corporation Hindawi Limited
Subjects:	Fertilization in vitro Fetal growth retardation Health aspects Twins
Online Access:	Get full text
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Summary:	Objective. Our objective was to estimate degree and rate of discordant growth and its impact on perinatal outcome in dichorionic twin pregnancies conceived by in vitro fertilization (IVF) compared to those conceived spontaneously. Study Design. Growth discordance was defined as 90th percentiles for the study population. Adverse perinatal outcome was defined as 5-minute Apgar score < 7 and/or admission to neonatal intensive care unit. Results. In the total study population of dichorionic twins (176 conceived by IVF and 215 spontaneously), 30% discordant growth represented the 90th percentile. After adjusting for gestational age, discordant twins conceived by IVF or spontaneously were at higher risk for adverse perinatal outcome (hazard ratio 4.4; 95% CI 2.4–8.3, P < 0.0001 ; hazard ratio 2.5; 95% CI 1.5–4.4, P = 0.001 , resp.). Similar rates of 5-minute Apgar score < 7 , admission to neonatal intensive care unit, and delivery < 34 weeks were found between discordant twins conceived by IVF and those conceived spontaneously. Conclusion. Dichorionic twins conceived by IVF are at similar risk for the rate and degree of discordant growth and adverse perinatal outcome compared to dichorionic twins conceived spontaneously.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Curt W. Burger
ISSN:	1687-9589 1687-9597 1687-9589
DOI:	10.1155/2014/543728