Search Results - "Milos, Patrice"

RNA sequencing: advances, challenges and opportunities by Ozsolak, Fatih, Milos, Patrice M

“…Key Points Powered by improving next-generation sequencing capabilities, RNA-seq studies continue to provide knowledge about the quantitative and qualitative…”
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Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation by Ozsolak, Fatih, Kapranov, Philipp, Foissac, Sylvain, Kim, Sang Woo, Fishilevich, Elane, Monaghan, A. Paula, John, Bino, Milos, Patrice M.

“…The emerging discoveries on the link between polyadenylation and disease states underline the need to fully characterize genome-wide polyadenylation states…”
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The properties and applications of single-molecule DNA sequencing by Thompson, John F, Milos, Patrice M

“…Single-molecule sequencing enables DNA or RNA to be sequenced directly from biological samples, making it well-suited for diagnostic and clinical applications…”
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Protocol dependence of sequencing-based gene expression measurements by Raz, Tal, Kapranov, Philipp, Lipson, Doron, Letovsky, Stan, Milos, Patrice M, Thompson, John F

“…RNA Seq provides unparalleled levels of information about the transcriptome including precise expression levels over a wide dynamic range. It is essential to…”
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Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation by Sherstnev, Alexander, Duc, Céline, Cole, Christian, Zacharaki, Vasiliki, Hornyik, Csaba, Ozsolak, Fatih, Milos, Patrice M, Barton, Geoffrey J, Simpson, Gordon G

“…RNA 3′-end formation is thought to be crucial in controlling gene expression. Direct RNA sequencing was used to analyze the 3′ ends of Arabidopsis thaliana RNA…”
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RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis by Yu, Min, Ting, David T., Stott, Shannon L., Wittner, Ben S., Ozsolak, Fatih, Paul, Suchismita, Ciciliano, Jordan C., Smas, Malgorzata E., Winokur, Daniel, Gilman, Anna J., Ulman, Matthew J., Xega, Kristina, Contino, Gianmarco, Alagesan, Brinda, Brannigan, Brian W., Milos, Patrice M., Ryan, David P., Sequist, Lecia V., Bardeesy, Nabeel, Ramaswamy, Sridhar, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.

“…A new method allows the collection of circulating tumour cells (CTCs) despite their rarity; transcriptome sequencing of CTCs could allow identification of…”
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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival by Scadden, David T, Bardeesy, Nabeel, Gurumurthy, Sushma, Xie, Stephanie Z, Alagesan, Brinda, Kim, Judith, Yusuf, Rushdia Z, Saez, Borja, Tzatsos, Alexandros, Ozsolak, Fatih, Milos, Patrice, Ferrari, Francesco, Park, Peter J, Shirihai, Orian S

“…Haematopoietic stem cells (HSCs) can convert between growth states that have marked differences in bioenergetic needs. Although often quiescent in adults,…”
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Direct RNA sequencing by Reifenberger, Jeffrey G, Jarosz, Mirna, Bowers, Jayson, Platt, Adam R, Sass, Lauryn E, Thompson, John F, Jones, Dan R, Milos, Patrice M, McInerney, Peter, Ozsolak, Fatih

“…Our understanding of human biology and disease is ultimately dependent on a complete understanding of the genome and its functions. The recent application of…”
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An in-depth map of polyadenylation sites in cancer by Lin, Yuefeng, Li, Zhihua, Ozsolak, Fatih, Kim, Sang Woo, Arango-Argoty, Gustavo, Liu, Teresa T, Tenenbaum, Scott A, Bailey, Timothy, Monaghan, A Paula, Milos, Patrice M, John, Bino

“…We present a comprehensive map of over 1 million polyadenylation sites and quantify their usage in major cancers and tumor cell lines using direct RNA…”
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Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6 by Sharma, Ankur, Huard, Christine, Vernochet, Cecile, Ziemek, Daniel, Knowlton, Kelly M, Tyminski, Edyta, Paradis, Theresa, Zhang, Ying, Jones, Jessica E C, von Schack, David, Brown, Christopher T, Milos, Patrice M, Coyle, Anthony J, Tremblay, Frederic, Martinez, Robert V

“…Brown adipose tissue (BAT) plays a pivotal role in promoting energy expenditure by the virtue of uncoupling protein-1 (UCP-1) that differentiates BAT from its…”
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On the importance of small changes in RNA expression by St. Laurent, Georges, Shtokalo, Dmitry, Tackett, Michael R., Yang, Zhaoqing, Vyatkin, Yuri, Milos, Patrice M., Seilheimer, Bernd, McCaffrey, Timothy A., Kapranov, Philipp

“…The analysis of the differential expression of genes has been the key goal of many molecular biology methods for decades and will remain with us for decades to…”
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Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA by Bernstein, Bradley E, Goren, Alon, Ozsolak, Fatih, Shoresh, Noam, Ku, Manching, Adli, Mazhar, Hart, Chris, Gymrek, Melissa, Zuk, Or, Regev, Aviv, Milos, Patrice M

“…Chromatin structure and transcription factor localization can be assayed genome-wide by sequencing genomic DNA fractionated by protein occupancy or other…”
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Transcriptome profiling using single-molecule direct RNA sequencing by Ozsolak, Fatih, Milos, Patrice M

“…Methods for in-depth characterization of transcriptomes and quantification of transcript levels have emerged as valuable tools for understanding cellular…”
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Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides by Kooner, Jaspal S, Chambers, John C, Aguilar-Salinas, Carlos A, Hinds, David A, Hyde, Craig L, Warnes, Gregory R, Gómez Pérez, Francisco J, Frazer, Kelly A, Elliott, Paul, Scott, James, Milos, Patrice M, Cox, David R, Thompson, John F

“…We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with…”
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The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA by Kapranov, Philipp, St Laurent, Georges, Raz, Tal, Ozsolak, Fatih, Reynolds, C Patrick, Sorensen, Poul H B, Reaman, Gregory, Milos, Patrice, Arceci, Robert J, Thompson, John F, Triche, Timothy J

“…Discovery that the transcriptional output of the human genome is far more complex than predicted by the current set of protein-coding annotations and that most…”
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Profiling of short RNAs using Helicos single-molecule sequencing by Kapranov, Philipp, Ozsolak, Fatih, Milos, Patrice M

“…The importance of short (<200 nt) RNAs in cell biogenesis has been well documented. These short RNAs include crucial classes of molecules such as transfer…”
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Quantification of the yeast transcriptome by single-molecule sequencing by Lipson, Doron, Raz, Tal, Kieu, Alix, Jones, Daniel R, Giladi, Eldar, Thayer, Edward, Thompson, John F, Letovsky, Stan, Milos, Patrice, Causey, Marie

“…Lipson et al . profile the yeast transcriptome using single-molecule sequencing. This approach avoids the inherent biases of the digestion, ligation and…”
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Single-molecule direct RNA sequencing without cDNA synthesis by Ozsolak, Fatih, Milos, Patrice M.

“…Methods for in‐depth genome‐wide characterization of transcriptomes and quantification of transcript levels using various microarray and next‐generation…”
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New models of collaboration in genome-wide association studies: the Genetic Association Information Network by Manolio, Teri A, Rodriguez, Laura Lyman, Brooks, Lisa, Abecasis, Gonçalo, Ballinger, Dennis, Daly, Mark, Donnelly, Peter, Faraone, Stephen V, Frazer, Kelly, Gabriel, Stacey, Gejman, Pablo, Guttmacher, Alan, Harris, Emily L, Insel, Thomas, Kelsoe, John R, Lander, Eric, McCowin, Norma, Mailman, Matthew D, Nabel, Elizabeth, Ostell, James, Pugh, Elizabeth, Sherry, Stephen, Sullivan, Patrick F, Thompson, John F, Warram, James, Wholley, David, Milos, Patrice M, Collins, Francis S

“…The Genetic Association Information Network (GAIN) is a public-private partnership established to investigate the genetic basis of common diseases through a…”
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A comparison of single molecule and amplification based sequencing of cancer transcriptomes by Sam, Lee T, Lipson, Doron, Raz, Tal, Cao, Xuhong, Thompson, John, Milos, Patrice M, Robinson, Dan, Chinnaiyan, Arul M, Kumar-Sinha, Chandan, Maher, Christopher A

“…The second wave of next generation sequencing technologies, referred to as single-molecule sequencing (SMS), carries the promise of profiling samples directly…”
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