Search Results - "Milo, Tomer"
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A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks
Published in Molecular systems biology (01-07-2020)“…Stress activates a complex network of hormones known as the hypothalamic–pituitary–adrenal (HPA) axis. The HPA axis is dysregulated in chronic stress and…”
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2
The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts
Published in Nature communications (19-09-2023)“…The tumor microenvironment (TME) is comprised of non-malignant cells that interact with each other and with cancer cells, critically impacting cancer biology…”
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3
Hormone seasonality in medical records suggests circannual endocrine circuits
Published in Proceedings of the National Academy of Sciences - PNAS (16-02-2021)“…Hormones control the major biological functions of stress response, growth, metabolism, and reproduction. In animals, these hormones show pronounced…”
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Major depressive disorder and bistability in an HPA-CNS toggle switch
Published in PLoS computational biology (01-12-2023)“…Major depressive disorder (MDD) is the most common psychiatric disorder. It has a complex and heterogeneous etiology. Most treatments take weeks to show…”
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Dynamics of thyroid diseases and thyroid‐axis gland masses
Published in Molecular systems biology (01-08-2022)“…Thyroid disorders are common and often require lifelong hormone replacement. Treating thyroid disorders involves a fascinating and troublesome delay, in which…”
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Excitable dynamics of flares and relapses in autoimmune diseases
Published in iScience (17-11-2023)“…Many autoimmune disorders exhibit flares in which symptoms erupt and then decline, as exemplified by multiple sclerosis (MS) in its relapsing-remitting form…”
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Endocrine gland size is proportional to its target tissue size
Published in iScience (20-09-2024)“…Endocrine glands secrete hormones into the circulation to target distant tissues and regulate their functions. The qualitative relationship between…”
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Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamics
Published in iScience (15-03-2024)“…Bipolar disorder (BD) is marked by fluctuating mood states over months to years, often with elevated cortisol levels. Elevated cortisol can also trigger mood…”
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Timescales of Human Hair Cortisol Dynamics
Published in iScience (25-09-2020)“…Cortisol is a major human stress hormone, secreted within minutes of acute stress. Cortisol also has slower patterns of variation: a strong circadian rhythm…”
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Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance
Published in Trends in immunology (01-05-2023)“…Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are common human thyroid autoimmune diseases with opposite clinical manifestations.GD and HT originate…”
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Major depressive disorder and bistability in an HPA-CNS toggle switch
Published in PLoS computational biology (01-12-2023)Get full text
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12
On the Many Faces of Easily Covered Polytopes
Published 23-10-2024“…Assume that $rB_{2}^{n} \subset P$ for some polytope $P \subset \mathbb{R}^n$, where $r \in (\frac{1}{2},1]$. Denote by $\mathcal{F}$ the set of facets of $P$,…”
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Robust CATE Estimation Using Novel Ensemble Methods
Published 04-07-2024“…The estimation of Conditional Average Treatment Effects (CATE) is crucial for understanding the heterogeneity of treatment effects in clinical trials. We…”
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