Search Results - "Milner, Jennifer M"

Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis by Milner, Jennifer M, Kevorkian, Lara, Young, David A, Jones, Debra, Wait, Robin, Donell, Simon T, Barksby, Emma, Patterson, Angela M, Middleton, Jim, Cravatt, Benjamin F, Clark, Ian M, Rowan, Andrew D, Cawston, Timothy E

“…Arthritis is characterised by the proteolytic degradation of articular cartilage leading to a loss of joint function. Articular cartilage is composed of an…”
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Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms by Wilkinson, David J., Habgood, Angela, Lamb, Heather K., Thompson, Paul, Hawkins, Alastair R., Désilets, Antoine, Leduc, Richard, Steinmetzer, Torsten, Hammami, Maya, Lee, Melody S., Craik, Charles S., Watson, Sharon, Lin, Hua, Milner, Jennifer M., Rowan, Andrew D.

“…Objective To assess the ability of matriptase, a type II transmembrane serine proteinase, to promote aggrecan loss from the cartilage of patients with…”
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The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover by Wilkinson, David J., Desilets, Antoine, Lin, Hua, Charlton, Sarah, del Carmen Arques, Maria, Falconer, Adrian, Bullock, Craig, Hsu, Yu-Chen, Birchall, Kristian, Hawkins, Alastair, Thompson, Paul, Ferrell, William R., Lockhart, John, Plevin, Robin, Zhang, Yadan, Blain, Emma, Lin, Shu-Wha, Leduc, Richard, Milner, Jennifer M., Rowan, Andrew D.

“…Increasing evidence implicates serine proteinases in the proteolytic cascades leading to the pathological destruction of extracellular matrices such as…”
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Metalloproteases as potential therapeutic targets in arthritis treatment by Rowan, Andrew D, Litherland, Gary J, Hui, Wang, Milner, Jennifer M

“…Dysregulated proteolysis of the extracellular matrix of articular cartilage represents a unifying hallmark of the arthritides, and has been a target for…”
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Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis by Milner, Jennifer M, Rowan, Andrew D, Cawston, Tim E, Young, David A

“…Excess proteolysis of the extracellular matrix (ECM) of articular cartilage is a key characteristic of arthritis. The main enzymes involved belong to the…”
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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis by Milner, Jennifer M., Patel, Amit, Davidson, Rose K., Swingler, Tracey E., Desilets, Antoine, Young, David A., Kelso, Elizabeth B., Donell, Simon T., Cawston, Tim E., Clark, Ian M., Ferrell, William R., Plevin, Robin, Lockhart, John C., Leduc, Richard, Rowan, Andrew D.

“…Objective Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane…”
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Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases by Milner, Jennifer M, Cawston, Tim E

“…The matrix metalloproteinases (MMPs) comprise a family of enzymes that collectively can degrade all components of the extracellular matrix (ECM). MMPs play an…”
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185. Screening Adolescents for Pregnancy When CT Imaging is Performed in the Emergency Department by Motheral, Lesley, MD, Johnson, Lara, MD, MHS, Milner, Jennifer, MD

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