Search Results - "Milner, Eric C. B"

A New Population of Cells Lacking Expression of CD27 Represents a Notable Component of the B Cell Memory Compartment in Systemic Lupus Erythematosus by Wei, Chungwen, Anolik, Jennifer, Cappione, Amedeo, Zheng, Bo, Pugh-Bernard, Aimee, Brooks, James, Lee, Eun-Hyung, Milner, Eric C. B, Sanz, Inaki

“…Human memory B cells comprise isotype-switched and nonswitched cells with both subsets displaying somatic hypermutation. In addition to somatic hypermutation,…”
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Cutting Edge: Anti-Tumor Necrosis Factor Therapy in Rheumatoid Arthritis Inhibits Memory B Lymphocytes via Effects on Lymphoid Germinal Centers and Follicular Dendritic Cell Networks by Anolik, Jennifer H, Ravikumar, Rajan, Barnard, Jennifer, Owen, Teresa, Almudevar, Anthony, Milner, Eric C. B, Miller, Chase H, Dutcher, Paul O, Hadley, James A, Sanz, Inaki

“…Rheumatoid arthritis (RA) is mediated by a proinflammatory cytokine network with TNF at its apex. Accordingly, drugs that block TNF have demonstrated…”
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Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM by Quách, Tâm D, Manjarrez-Orduño, Nataly, Adlowitz, Diana G, Silver, Lin, Yang, Hongmei, Wei, Chungwen, Milner, Eric C B, Sanz, Iñaki

“…B cell anergy represents an important mechanism of peripheral immunological tolerance for mature autoreactive B cells that escape central tolerance enforced by…”
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CpG DNA activation and plasma-cell differentiation of CD27− naive human B cells by Huggins, Jennifer, Pellegrin, Tina, Felgar, Raymond E., Wei, Chungwen, Brown, Miguel, Zheng, Bo, Milner, Eric C.B., Bernstein, Steven H., Sanz, Ignacio, Zand, Martin S.

“…Unmethylated CpG DNA activation of naive CD27− B cells has been reported to require B-cell–receptor (BCR) cross-linking. We describe a culture system using CpG…”
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Human innate B cells: a link between host defense and autoimmunity? by Milner, Eric C B, Anolik, Jennifer, Cappione, Amedeo, Sanz, Iñaki

“…B cells play a variety of immunoregulatory roles through their antigen-presentation ability and through cytokine and chemokine production. Innate immune…”
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B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny by Anolik, Jennifer H, Friedberg, Jonathan W, Zheng, Bo, Barnard, Jennifer, Owen, Teresa, Cushing, Emily, Kelly, Jennifer, Milner, Eric C.B, Fisher, Richard I, Sanz, Iñaki

“…Abstract The long-term immunologic effects of B cell depletion with rituximab and the characteristics of the reconstituting B cell pool in lymphoma patients…”
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Impact of HIV-1 Infection on VH3 Gene Repertoire of Naive Human B Cells by Scamurra, Ronald W, Miller, Darren J, Dahl, Linda, Abrahamsen, Mitchell, Kapur, Vivek, Wahl, Sharon M, Milner, Eric C. B, Janoff, Edward N

“…B cells of the largest Ig variable heavy chain gene (VH) family, VH3, are reportedly decreased in patients with late stage HIV-1 disease. This deficit may…”
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Chromosomal Organization of the Heavy Chain Variable Region Gene Segments Comprising the Human Fetal Antibody Repertoire by Van Dijk, Ko Willems, Milner, Laurie A., Sasso, Eric H., Eric C. B. Milner

“…The adult repertoire of antibody specificities is acquired in a developmentally programed fashion that, in mouse and man, parallels the ordered rearrangement…”
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B-cell–autonomous somatic mutation deficit following bone marrow transplant by Glas, Annuska M., van Montfort, Erwin H. N., Storek, Jan, Green, Emily-Gene N., Drissen, Roy P. M., Bechtold, Viviane J., Reilly, J. Zachary, Dawson, Monja A., Milner, Eric C. B.

“…Hematopoietic stem cell transplantation is characterized by a prolonged period of humoral immunodeficiency. We have previously shown that the deficiencies are…”
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B-cell-autonomous somatic mutation deficit following bone marrow transplant by GLAS, A. M, VAN MONTFORT, E. H. N, STOREK, J, GREEN, E.-G. N, DRISSEN, R. P. M, BECHTOLD, V. J, REILLY, J. Z, DAWSON, M. A, MILNER, E. C. B

“…Hematopoietic stem cell transplantation is characterized by a prolonged period of humoral immunodeficiency. We have previously shown that the deficiencies are…”
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Polymorphism and utilization of human VH Genes by Milner, E C, Hufnagle, W O, Glas, A M, Suzuki, I, Alexander, C

“…The human VH germline repertoire comprises approximately 100 elements, which can be grouped into seven families based on nucleotide sequence similarity…”
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The human immunoglobulin VH7 gene family consists of a small, polymorphic group of six to eight gene segments dispersed throughout the VH locus by van Dijk, K W, Mortari, F, Kirkham, P M, Schroeder, Jr, H W, Milner, E C

“…In this report we describe the analysis and mapping of members of the human immunoglobulin VH7 gene family. VH7 and VH1 gene segments are closely related, with…”
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A complete preimmune human VH3 repertoire by Hufnagle, W O, Huang, S C, Suzuki, I, Milner, E C

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Linkage analyses of five chromosome 4 markers localizes the facioscapulohumeral muscular dystrophy (FSHD) gene to distal 4q35 by Weiffenbach, B, Bagley, R, Falls, K, Hyser, C, Storvick, D, Jacobsen, S J, Schultz, P, Mendell, J, Willems van Dijk, K, Milner, E C

“…The genetic locus for facioscapulohumeral muscular dystrophy (FSHD) has been mapped to chromosome 4. We have examined linkage to five chromosome 4q DNA markers…”
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Physical Linkage of a Human Immunoglobulin Heavy Chain Variable Region Gene Segment to Diversity and Joining Region Elements by Schroeder, Harry W., Walter, Michael A., Hofker, Marten H., Ebens, Allen, Van Dijk, Ko Willems, Liao, Linda C., Cox, Diane W., Eric C. B. Milner, Perlmutter, Roger M.

“…Antibody genes are assembled from a series of germ-line gene segments that are juxtaposed during the maturation of B lymphocytes. Although diversification of…”
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Patterns of V-region gene segment association in the human antibody response to Haemophilus influenzae type B capsular polysaccharide by Pinchuk, G V, Nottenburg, C, Milner, E C

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Anomalous diversification of the antibody repertoire following bone marrow transplantation by Glas, A M, Hufnagle, W O, Suzuki, I, Pfister, L, Rao, P S, Nottenburg, C, Milner, E C

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Mutational Analysis of the HLA-DQ3.2 Insulin-Dependent Diabetes Mellitus Susceptibility Gene by Kwok, William W., Lotshaw, Carla, Eric C. B. Milner, Knitter-Jack, Nan, Nepom, Gerald T.

“…The human major histocompatibility complex includes approximately 14 class II HLA genes within the HLA-D region, most of which exist in multiple allelic forms…”
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Sequence analysis of monoclonal antibodies derived from a patient with idiopathic thrombocytopenic purpura by Hiraiwa, A, Nugent, D J, Milner, E C

“…Autoantibodies directed at the platelet membrane glycoprotein Ib (GPIb) can mediate a severe form of idiopathic thrombocytopenic purpura (ITP). The…”
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Sequence analysis of HLA class II domains: characterization of the DQw3 family of DQB genes by HIRAIWA, A, SEYFRIED, C. E, NEPOM, G. T, MILNER, E. C. B

“…HLA class II allelic variants within the DQw3-related family of genes carry distinct allo-specificities and have been implicated in specific HLA-disease…”
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