Search Results - "Millward, Makenzie J"

Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds by Millward, Makenzie J, Ellis, Emily, Ward, John W, Clayden, Jonathan

“…Bicyclic or tricyclic nitrogen-containing heterocyclic scaffolds were constructed rapidly by intramolecular nucleophilic aromatic substitution of metallated…”
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Synthesis of Medium Rings Through Ring Expansion Reactions of Metallated Ureas Containing Non-Aromatic Anion Stabilising Groups by Millward, Makenzie J

“…Cyclic structures containing between 8- and 12-members are classified as medium rings. Various bioactive natural products have been isolated containing these…”
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Free–Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of N‑Methylation for PI3Kδ Activity by Barnes, Lydia, Blaber, Hollie, Brooks, David T. K, Byers, Lewis, Buckley, Daniel, Byron, Zoe C, Chilvers, Richard G, Cochrane, Liam, Cooney, Edward, Damian, Heather A, Francis, Luke, Fu He, Daniel, Grace, Jack M. J, Green, Harley J, Hogarth, Edmund J. P, Jusu, Leyla, Killalea, C. Elizabeth, King, Oliver, Lambert, Joseph, Lee, Zoe J, Lima, Nuria S, Long, Christina L, Mackinnon, May-Li, Mahdy, Shusha, Matthews-Wright, Jolyon, Millward, Makenzie J, Meehan, Matthew F, Merrett, Christopher, Morrison, Lisa, Parke, Hal R. I, Payne, Charlotte, Payne, Lawrence, Pike, Craig, Seal, Alexander, Senior, Aaron J, Smith, Keenan M, Stanelyte, Kamile, Stillibrand, Joe, Szpara, Rachel, Taday, Freya F. H, Threadgould, Antony M, Trainor, Rohan J, Waters, Jordan, Williams, Oliver, Wong, Carrie K. W, Wood, Katherine, Barton, Nick, Gruszka, Anna, Henley, Zoe, Rowedder, James E, Cookson, Rosa, Jones, Katherine L, Nadin, Alan, Smith, Ian E, Macdonald, Simon J. F, Nortcliffe, Andrew

“…Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of…”
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