Search Results - "Mills, R"
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The therapeutic potential of galectin-3 inhibition in fibrotic disease
Published in The international journal of biochemistry & cell biology (01-01-2021)“…Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member galectin family that are evolutionarily highly conserved. It is the only…”
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Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults
Published in Blood (02-02-2017)“…Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and…”
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Shuttling a single charge across a one-dimensional array of silicon quantum dots
Published in Nature communications (05-03-2019)“…Significant advances have been made towards fault-tolerant operation of silicon spin qubits, with single qubit fidelities exceeding 99.9%, several…”
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Targeting TRK family proteins in cancer
Published in Pharmacology & therapeutics (Oxford) (01-05-2017)“…The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins, which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding…”
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Characteristics of fasciculations in amyotrophic lateral sclerosis and the benign fasciculation syndrome
Published in Brain (London, England : 1878) (01-11-2010)“…The aim of this study was to determine first, if benign fasciculations and those in amyotrophic lateral sclerosis can de distinguished on the basis of their…”
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Evaluating the performance of parallel subsurface simulators: An illustrative example with PFLOTRAN
Published in Water resources research (01-01-2014)“…To better inform the subsurface scientist on the expected performance of parallel simulators, this work investigates performance of the reactive multiphase…”
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Hydrothermal impacts on trace element and isotope ocean biogeochemistry
Published in Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences (28-11-2016)“…Hydrothermal activity occurs in all ocean basins, releasing high concentrations of key trace elements and isotopes (TEIs) into the oceans. Importantly, the…”
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The microbiome mediates the interaction between predation and heavy metals
Published in The Science of the total environment (25-06-2021)“…Gut microbiota communities are fundamental ecological components in the aquatic food web. Their potential to mediate how organisms respond to multiple…”
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A Deep Learning Framework for Predicting Response to Therapy in Cancer
Published in Cell reports (Cambridge) (10-12-2019)“…A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a personalized basis. Using a pharmacogenomics database of 1,001…”
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Computer-automated tuning procedures for semiconductor quantum dot arrays
Published in Applied physics letters (09-09-2019)“…As with any quantum computing platform, semiconductor quantum dot devices require sophisticated hardware and controls for operation. The increasing complexity…”
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Trends in healthcare utilisation during COVID-19: a longitudinal study from the UK
Published in BMJ open (30-07-2021)“…ObjectiveThe first wave of the COVID-19 pandemic had a major impact on healthcare utilisation. The aim of this retrospective review was to quantify how…”
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Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
Published in The New England journal of medicine (30-05-2013)“…More than 25% of patients with AML carry no mutations in genes known to be associated with leukemia. Analyses of genomes, transcriptomes, and methylomes of AML…”
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Autoimmune/Paraneoplastic Encephalitis Antibody Biomarkers: Frequency, Age, and Sex Associations
Published in Mayo Clinic proceedings (01-03-2022)“…To determine the frequency of detection and the age and sex associations of autoimmune/paraneoplastic encephalitis antibody biomarkers (AE-Abs). There were…”
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Detecting fasciculations in amyotrophic lateral sclerosis: duration of observation required
Published in Journal of neurology, neurosurgery and psychiatry (01-05-2011)“…A practical issue in the diagnosis of amyotrophic lateral sclerosis (ALS) is how long the EMG must be observed before a muscle can be declared free of…”
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Aetiology and pathology of otitis media with effusion in adult life
Published in Journal of laryngology and otology (01-05-2016)“…To gather and analyse information concerning the aetiology and pathology of otitis media with effusion in adults. A review of the English language literature…”
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CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A
Published in Cell reports (Cambridge) (14-06-2016)“…Targeting translation initiation is an emerging anti-neoplastic strategy that capitalizes on de-regulated upstream MAPK and PI3K-mTOR signaling pathways in…”
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The Status and Impact of Clinical Tumor Genome Sequencing
Published in Annual review of genomics and human genetics (31-08-2019)“…Since the discovery that DNA alterations initiate tumorigenesis, scientists and clinicians have been exploring ways to counter these changes with targeted…”
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David Hume and the myth of the 'Warburtonian School'
Published in History of European ideas (17-02-2023)“…David Hume (1711-1776) believed a 'confederacy of authors', brought together by the notoriously pugnacious William Warburton (1698-1779), were his most…”
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