Search Results - "Mills, L Reginald"

Selective Carbon-Carbon Bond Cleavage of Cyclopropanols by McDonald, Tyler R, Mills, L Reginald, West, Michael S, Rousseaux, Sophie A L

“…The carbon-carbon (C-C) bond cleavage of cyclopropanols is a wide area of research with much current activity. This review highlights new developments in this…”
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Modern Developments in the Chemistry of Homoenolates by Mills, L. Reginald, Rousseaux, Sophie A. L.

“…Homoenolates are unique synthetic intermediates which display umpolung reactivity. Homoenolates and homoenolate equivalents like cyclopropanols have seen a…”
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Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation by Mills, L. Reginald, Graham, Joshua M, Patel, Purvish, Rousseaux, Sophie A. L

“…Herein, we report a Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl (pseudo)­halides and an electrophilic cyanating reagent,…”
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Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines by Mills, L. Reginald, Barrera Arbelaez, Luis Miguel, Rousseaux, Sophie A. L

“…Metal homoenolates, produced via C–C bond cleavage of cyclopropanols, have been extensively investigated as nucleophiles for the synthesis of β-substituted…”
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Ni-Catalyzed β‑Alkylation of Cyclopropanol-Derived Homoenolates by Mills, L. Reginald, Zhou, Cuihan, Fung, Emily, Rousseaux, Sophie A. L

“…Metal homoenolates are valuable synthetic intermediates which provide access to β-functionalized ketones. In this report, we disclose a Ni-catalyzed…”
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Design of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles by Mills, L. Reginald, Edjoc, Racquel K, Rousseaux, Sophie A. L

“…The design of new ligands for cross-coupling is essential for developing new catalytic reactions that access valuable products such as pharmaceuticals. In this…”
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Mechanistic Investigations of Phenoxyimine–Cobalt(II)-Catalyzed C(sp2)–C(sp3) Suzuki–Miyaura Cross-Coupling by Mills, L. Reginald, Gygi, David, Simmons, Eric M., Wisniewski, Steven R., Kim, Junho, Chirik, Paul J.

“…The mechanism of phenoxyimine (FI)−cobalt-catalyzed C­(sp2)–C­(sp3) Suzuki–Miyaura cross-coupling was studied using a combination of kinetic measurements and…”
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(Phenoxyimine)nickel-Catalyzed C(sp2)–C(sp3) Suzuki–Miyaura Cross-Coupling: Evidence for a Recovering Radical Chain Mechanism by Mills, L. Reginald, Simmons, Eric M., Lee, Heejun, Nester, Eva, Kim, Junho, Wisniewski, Steven R., Pecoraro, Matthew V., Chirik, Paul J.

“…Phenoxyimine (FI)–nickel­(II)­(2-tolyl)­(DMAP) compounds were synthesized and evaluated as precatalysts for the C­(sp2)–C­(sp3) Suzuki–Miyaura cross coupling…”
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Phenoxythiazoline (FTz)‐Cobalt(II) Precatalysts Enable C(sp2)–C(sp3) Bond‐Formation for Key Intermediates in the Synthesis of Toll‐like Receptor 7/8 Antagonists by Mills, L. Reginald, Di Mare, Francesca, Gygi, David, Lee, Heejun, Simmons, Eric M., Kim, Junho, Wisniewski, Steven R., Chirik, Paul J.

“…Evaluation of the relative rates of the cobalt‐catalyzed C(sp2)–C(sp3) Suzuki–Miyaura cross‐coupling between the neopentylglycol ester of 4‐fluorophenylboronic…”
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Cobalt-Catalyzed C(sp2)–C(sp3) Suzuki–Miyaura Cross-Coupling Enabled by Well-Defined Precatalysts with L,X-Type Ligands by Mills, L. Reginald, Gygi, David, Ludwig, Jacob R, Simmons, Eric M, Wisniewski, Steven R, Kim, Junho, Chirik, Paul J

“…Cobalt­(II) halides in combination with phenoxyimine (FI) ligands generated efficient precatalysts in situ for the C­(sp2)–C­(sp3) Suzuki–Miyaura…”
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The Cyclopropane Ring as a Reporter of Radical Leaving-Group Reactivity for Ni-Catalyzed C(sp3)–O Arylation by Mills, L. Reginald, Monteith, John J, dos Passos Gomes, Gabriel, Aspuru-Guzik, Alán, Rousseaux, Sophie A. L

“…The ability to understand and predict reactivity is essential for the development of new reactions. In the context of Ni-catalyzed C­(sp3)–O functionalization,…”
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Ni-Catalyzed Synthesis of Thiocarboxylic Acid Derivatives by Monteith, John J, Scotchburn, Katerina, Mills, L. Reginald, Rousseaux, Sophie A. L

“…A Ni-catalyzed cross-coupling of readily accessible O-alkyl xanthate esters or thiocarbonyl imidazolides and organozinc reagents for the synthesis of…”
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Synthesis of trans-2-Substituted Cyclopropylamines from α‑Chloroaldehydes by West, Michael S, Mills, L. Reginald, McDonald, Tyler R, Lee, Jessica B, Ensan, Deeba, Rousseaux, Sophie A. L

“…Cyclopropylamines are prevalent in pharmaceuticals and agrochemicals. Herein, we report the synthesis of trans-2-substituted cyclopropylamines in high…”
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Phenoxythiazoline (FTz)‐Cobalt(II) Precatalysts Enable C(sp2)–C(sp3) Bond‐Formation for Key Intermediates in the Synthesis of Toll‐like Receptor 7/8 Antagonists by Mills, L. Reginald, Di Mare, Francesca, Gygi, David, Lee, Heejun, Simmons, Eric M., Kim, Junho, Wisniewski, Steven R., Chirik, Paul J.

“…Evaluation of the relative rates of the cobalt‐catalyzed C(sp2)–C(sp3) Suzuki–Miyaura cross‐coupling between the neopentylglycol ester of 4‐fluorophenylboronic…”
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A one-pot electrophilic cyanation–functionalization strategy for the synthesis of disubstituted malononitriles by Mills, L. Reginald, Rousseaux, Sophie A.L.

“…Malononitriles are valuable synthetic intermediates for many applications, including the synthesis of herbicides and other biologically active molecules, and…”
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C(sp3)–C(sp3) Reductive Elimination from (Phenoxyimine)Cobalt(III)(CH3)2(PMe3)2 Complexes by Mills, L. Reginald, Kim, Junho, Simmons, Eric M., Wisniewski, Steven R., Chirik, Paul J.

“…A series of six-coordinate, idealized octahedral phenoxyimine (FI)–cobalt­(III) dimethyl bis­(trimethylphosphine) complexes was synthesized and characterized…”
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Cover Feature: Modern Developments in the Chemistry of Homoenolates (Eur. J. Org. Chem. 1/2019) by Mills, L. Reginald, Rousseaux, Sophie A. L.

“…The Cover Feature shows a metal homoenolate intermediate in equilibrium between its ring‐opened and ring‐closed tautomeric forms. The ring‐opened form allows…”
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New Strategies for C–O and C–C Functionalization in the Contexts of Cyclopropanol Chemistry, Transnitrilation, and Ni Catalysis by Mills, L. Reginald

“…This thesis describes new methods for C–O and C–C functionalization in the contexts of cyclopropanol and homoenolate chemistry, transnitrilation, and Ni…”
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