Search Results - "Mills, Ken I."

Significance of NPM1 Gene Mutations in AML by Hindley, Andrew, Catherwood, Mark Alexander, McMullin, Mary Frances, Mills, Ken I.

“…The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include…”
Get full text

The Impact of Epigenetic Modifications in Myeloid Malignancies by Venney, Deirdra, Mohd-Sarip, Adone, Mills, Ken I

“…Myeloid malignancy is a broad term encapsulating myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Initial…”
Get full text

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group by HAFERLACH, Torsten, KOHLMANN, Alexander, GILKES, Amanda, CHIARETTI, Sabina, SHURTLEFF, Sheila A, KIPPS, Thomas J, RASSENTI, Laura Z, YEOH, Allen E, PAPENHAUSEN, Peter R, LIU, Wei-Min, WILLIAMS, P. Mickey, FOA, Robin, WIECZOREK, Lothar, BASSO, Giuseppe, TE KRONNIE, Geertruy, BONO, Marie-Christine, DE VOS, John, HERNINDEZ, Jesus M, HOFMANN, Wolf-Karsten, MILLS, Ken I

“…The Microarray Innovations in Leukemia study assessed the clinical utility of gene expression profiling as a single test to subtype leukemias into conventional…”
Get full text

TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors by McAvera, Roisin M., Morgan, Jonathan J., Herrero, Ana B., Mills, Ken I., Crawford, Lisa J.

“…Deletions of chromosome 1p (del(1p)) are a recurrent genomic aberration associated with poor outcome in Multiple myeloma (MM.) TRIM33, an E3 ligase and…”
Get full text

Erythropoietin in bone homeostasis—Implications for efficacious anemia therapy by Lappin, Katrina M., Mills, Ken I., Lappin, Terence R.

“…Bone homeostasis and hematopoiesis are irrevocably linked in the hypoxic environment of the bone marrow. Erythropoietin (Epo) regulates erythropoiesis by…”
Get full text

Combination Therapies Targeting Apoptosis in Paediatric AML: Understanding the Molecular Mechanisms of AML Treatments Using Phosphoproteomics by Ali, Ahlam A, Cairns, Lauren V, Clarke, Kathryn M, Blayney, Jaine K, Lappin, Katrina M, Mills, Ken I

“…Paediatric acute myeloid leukaemia (AML) continues to present treatment challenges, as no "standard approach" exists to treat those young patients reliably and…”
Get full text

Survivin’ Acute Myeloid Leukaemia—A Personalised Target for inv(16) Patients by Greiner, Jochen, Brown, Elliott, Bullinger, Lars, Hills, Robert K., Morris, Vanessa, Döhner, Hartmut, Mills, Ken I., Guinn, Barbara-ann

“…Despite recent advances in therapies including immunotherapy, patients with acute myeloid leukaemia (AML) still experience relatively poor survival rates. The…”
Get full text

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML by Smith, James S, Lappin, Katrina M, Craig, Stephanie G, Liberante, Fabio G, Crean, Clare M, McDade, Simon S, Thompson, Alexander, Mills, Ken I, Savage, Kienan I

“…The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early…”
Get full text

Multiplex Screening for Interacting Compounds in Paediatric Acute Myeloid Leukaemia by Cairns, Lauren V., Lappin, Katrina M., Mutch, Alexander, Ali, Ahlam, Matchett, Kyle B., Mills, Ken I.

“…Paediatric acute myeloid leukaemia (AML) is a heterogeneous disease characterised by the malignant transformation of myeloid precursor cells with impaired…”
Get full text

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics by O'Reilly, Paul G, Wen, Qing, Bankhead, Peter, Dunne, Philip D, McArt, Darragh G, McPherson, Suzanne, Hamilton, Peter W, Mills, Ken I, Zhang, Shu-Dong

“…Gene expression connectivity mapping has proven to be a powerful and flexible tool for research. Its application has been shown in a broad range of research…”
Get full text

Identification of Gene Expression–Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes by PELLAGATTI, Andrea, BENNER, Axel, MCDONALD, Emma-Jane, KILLICK, Sally, HELLSTRÖM-LINDBERG, Eva, BULLINGER, Lars, WAINSCOAT, James S, BOULTWOOD, Jacqueline, MILLS, Ken I, CAZZOLA, Mario, GIAGOUNIDIS, Aristoteles, PERRY, Janet, MALCOVATI, Luca, DELLA PORTA, Matteo G, JÄDERSTEN, Martin, VERMA, Amit

“…The diagnosis of patients with myelodysplastic syndromes (MDS) is largely dependent on morphologic examination of bone marrow aspirates. Several criteria that…”
Get full text

Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn's-like Lymphoid Reaction by Boncheva, Viktoriya B, Linnebacher, Michael, Kdimati, Said, Draper, Hannah, Orchard, Laurence, Mills, Ken I, O'Sullivan, Gerald, Tangney, Mark, Guinn, Barbara-Ann

“…A Crohn’s-like lymphoid reaction (CLR) is observed in about 15% of colorectal cancer (CRC) patients and is associated with favourable outcomes. To identify the…”
Get full text

Erythropoietin drives breast cancer progression by activation of its receptor EPOR by Chan, Ka Kui, Matchett, Kyle B, Coulter, Jonathan A, Yuen, Hiu-Fung, McCrudden, Cian M, Zhang, Shu-Dong, Irwin, Gareth W, Davidson, Matthew A, Rülicke, Thomas, Schober, Sophie, Hengst, Ludger, Jaekel, Heidelinde, Platt-Higgins, Angela, Rudland, Philip S, Mills, Ken I, Maxwell, Perry, El-Tanani, Mohamed, Lappin, Terence R

“…Breast cancer is a leading cause of cancer-related deaths. Anemia is common in breast cancer patients and can be treated with blood transfusions or with…”
Get full text

Deregulation of genes related to iron and mitochondrial metabolism in refractory anemia with ring sideroblasts by del Rey, Mónica, Benito, Rocío, Fontanillo, Celia, Campos-Laborie, Francisco J, Janusz, Kamila, Velasco-Hernández, Talía, Abáigar, María, Hernández, María, Cuello, Rebeca, Borrego, Daniel, Martín-Zanca, Dionisio, De Las Rivas, Javier, Mills, Ken I, Hernández-Rivas, Jesús M

“…The presence of SF3B1 gene mutations is a hallmark of refractory anemia with ring sideroblasts (RARS). However, the mechanisms responsible for iron…”
Get full text

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis by Dias, Ingrid R. S. B., Costa, Rafaela G. A., Rodrigues, Ana Carolina B. da C., Silva, Suellen L. R., Oliveira, Maiara de S., Soares, Milena B. P., Dias, Rosane B., Valverde, Ludmila F., Gurgel Rocha, Clarissa A., Cairns, Lauren V., Mills, Ken I., Bezerra, Daniel P.

“…Acute myeloid leukaemia (AML) is a lethal bone marrow neoplasm caused by genetic alterations in blood cell progenitors. Leukaemic stem cells (LSCs) are…”
Get full text

Application of the pMHC Array to Characterise Tumour Antigen Specific T Cell Populations in Leukaemia Patients at Disease Diagnosis by Brooks, Suzanne E, Bonney, Stephanie A, Lee, Cindy, Publicover, Amy, Khan, Ghazala, Smits, Evelien L, Sigurdardottir, Dagmar, Arno, Matthew, Li, Demin, Mills, Ken I, Pulford, Karen, Banham, Alison H, van Tendeloo, Viggo, Mufti, Ghulam J, Rammensee, Hans-Georg, Elliott, Tim J, Orchard, Kim H, Guinn, Barbara-ann

“…Immunotherapy treatments for cancer are becoming increasingly successful, however to further improve our understanding of the T-cell recognition involved in…”
Get full text

Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene‐Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia by Ramsey, Joanne M., Kettyle, Laura M.J., Sharpe, Daniel J., Mulgrew, Nuala M., Dickson, Glenda J., Bijl, Janet J., Austin, Pamela, Mayotte, Nadine, Cellot, Sonia, Lappin, Terence R.J., Zhang, Shu‐Dong, Mills, Ken I., Krosl, Jana, Sauvageau, Guy, Thompson, Alexander

“…The incidence of refractory acute myeloid leukemia (AML) is on the increase due in part to an aging population that fails to respond to traditional therapies…”
Get full text

Mutational spectrum defines primary and secondary myelofibrosis by Mills, Ken I, McMullin, Mary Frances

Get full text

HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy by Dickson, G. J., Liberante, F. G., Kettyle, L. M., O'Hagan, K. A., Finnegan, D. P. J., Bullinger, L., Geerts, D., McMullin, M. F., Lappin, T. R. J., Mills, K. I., Thompson, A.

“…The cytogenetically normal subtype of acute myeloid leukemia is associated with an intermediate risk which complicates therapeutic options. Lower overall…”
Get full text

Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes by Palau, Anna, Garz, Anne-Kathrin, Diesch, Jeannine, Zwick, Anabel, Malinverni, Roberto, Valero, Vanesa, Lappin, Katrina, Casquero, Raquel, Lennartsson, Andreas, Zuber, Johannes, Navarro, Tomàs, Mills, Ken I, Götze, Katharina S, Buschbeck, Marcus

“…Genetic lesions affecting epigenetic regulators are frequent in myelodysplastic syndromes (MDS). Polycomb proteins are key epigenetic regulators of…”
Get full text