Search Results - "Mills, Kathryn F."

Nicotinamide Mononucleotide, a Key NAD + Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice by Yoshino, Jun, Mills, Kathryn F., Yoon, Myeong Jin, Imai, Shin-ichiro

“…Type 2 diabetes (T2D) has become epidemic in our modern lifestyle, likely due to calorie-rich diets overwhelming our adaptive metabolic pathways. One such…”
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Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women by Yoshino, Mihoko, Yoshino, Jun, Kayser, Brandon D, Patti, Gary J, Franczyk, Michael P, Mills, Kathryn F, Sindelar, Miriam, Pietka, Terri, Patterson, Bruce W, Imai, Shin-Ichiro, Klein, Samuel

“…In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD ) biosynthesis, which contributes to metabolic dysfunction. Nicotinamide…”
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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice by Mills, Kathryn F., Yoshida, Shohei, Stein, Liana R., Grozio, Alessia, Kubota, Shunsuke, Sasaki, Yo, Redpath, Philip, Migaud, Marie E., Apte, Rajendra S., Uchida, Koji, Yoshino, Jun, Imai, Shin-ichiro

“…NAD+ availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance…”
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Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice by Ramsey, Kathryn Moynihan, Mills, Kathryn F., Satoh, Akiko, Imai, Shin‐ichiro

“…Summary The Sir2 (silent information regulator 2) family of NAD‐dependent deacetylases regulates aging and longevity across a wide variety of organisms,…”
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The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs by Ghisays, Fiorella, Brace, Cynthia S., Yackly, Shawn M., Kwon, Hyock Joo, Mills, Kathryn F., Kashentseva, Elena, Dmitriev, Igor P., Curiel, David T., Imai, Shin-ichiro, Ellenberger, Tom

“…The NAD+-dependent protein deacetylase SIRT1 regulates energy metabolism, responses to stress, and aging by deacetylating many different proteins, including…”
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Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice by Yoshida, Mitsukuni, Satoh, Akiko, Lin, Jonathan B., Mills, Kathryn F., Sasaki, Yo, Rensing, Nicholas, Wong, Michael, Apte, Rajendra S., Imai, Shin-ichiro

“…Aging is a significant risk factor for impaired tissue functions and chronic diseases. Age-associated decline in systemic NAD+ availability plays a critical…”
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Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice by Picciotto, Natalie E., Gano, Lindsey B., Johnson, Lawrence C., Martens, Christopher R., Sindler, Amy L., Mills, Kathryn F., Imai, Shin‐ichiro, Seals, Douglas R.

“…Summary We tested the hypothesis that supplementation of nicotinamide mononucleotide (NMN), a key NAD+ intermediate, increases arterial SIRT1 activity and…”
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Slc12a8 is a nicotinamide mononucleotide transporter by Grozio, Alessia, Mills, Kathryn F., Yoshino, Jun, Bruzzone, Santina, Sociali, Giovanna, Tokizane, Kyohei, Lei, Hanyue Cecilia, Cunningham, Richard, Sasaki, Yo, Migaud, Marie E., Imai, Shin-ichiro

“…Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of nicotinamide adenine dinucleotide (NAD + ) known to promote cellular NAD + production and…”
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Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme by Revollo, Javier R., Körner, Antje, Mills, Kathryn F., Satoh, Akiko, Wang, Tao, Garten, Antje, Dasgupta, Biplab, Sasaki, Yo, Wolberger, Cynthia, Townsend, R. Reid, Milbrandt, Jeffrey, Kiess, Wieland, Imai, Shin-ichiro

“…Intracellular nicotinamide phosphoribosyltransferase (iNampt) is an essential enzyme in the NAD biosynthetic pathway. An extracellular form of this protein…”
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SS‐31 and NMN: Two paths to improve metabolism and function in aged hearts by Whitson, Jeremy A., Bitto, Alessandro, Zhang, Huiliang, Sweetwyne, Mariya T., Coig, Rene, Bhayana, Saakshi, Shankland, Eric G., Wang, Lu, Bammler, Theo K., Mills, Kathryn F., Imai, Shin‐Ichiro, Conley, Kevin E., Marcinek, David J., Rabinovitch, Peter S.

“…The effects of two different mitochondrial‐targeted drugs, SS‐31 and NMN, were tested on Old mouse hearts. After treatment with the drugs, individually or…”
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Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS) by Unno, Junya, Mills, Kathryn F., Ogura, Tairo, Nishimura, Masayuki, Imai, Shin-ichiro

“…Nicotinamide adenine dinucleotide (NAD + ) is an essential metabolite for fundamental biological phenomena, including aging. Nicotinamide mononucleotide (NMN)…”
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Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter by Grozio, Alessia, Mills, Kathryn F., Yoshino, Jun, Bruzzone, Santina, Sociali, Giovanna, Tokizane, Kyohei, Lei, Hanyue Cecilia, Cunningham, Richard, Sasaki, Yo, Migaud, Marie E., Imai, Shin-ichiro

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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