Search Results - "Mills, I. G."

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse by Taavitsainen, S., Engedal, N., Cao, S., Handle, F., Erickson, A., Prekovic, S., Wetterskog, D., Tolonen, T., Vuorinen, E. M., Kiviaho, A., Nätkin, R., Häkkinen, T., Devlies, W., Henttinen, S., Kaarijärvi, R., Lahnalampi, M., Kaljunen, H., Nowakowska, K., Syvälä, H., Bläuer, M., Cremaschi, P., Claessens, F., Visakorpi, T., Tammela, T. L. J., Murtola, T., Granberg, K. J., Lamb, A. D., Ketola, K., Mills, I. G., Attard, G., Wang, W., Nykter, M., Urbanucci, A.

“…Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ…”
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UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation by Itkonen, H M, Engedal, N, Babaie, E, Luhr, M, Guldvik, I J, Minner, S, Hohloch, J, Tsourlakis, M C, Schlomm, T, Mills, I G

“…Prostate cancer is the second most common cause of cancer-associated deaths in men, and signaling via a transcription factor called androgen receptor (AR) is…”
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Nuclear LYRIC AEG-1 interacts with PLZF and relieves PLZF-mediated repression by Thirkettle, H J, Mills, I G, Whitaker, H C, Neal, D E

“…LYRIC/AEG-1 and its altered expression have been linked to carcinogenesis in prostate, brain and melanoma as well as promoting chemoresistance and metastasis…”
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Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer by Attard, G, Clark, J, Ambroisine, L, Mills, I G, Fisher, G, Flohr, P, Reid, A, Edwards, S, Kovacs, G, Berney, D, Foster, C, Massie, C E, Fletcher, A, De Bono, J S, Scardino, P, Cuzick, J, Cooper, C S

“…A fluorescence in situ hybridisation (FISH) assay has been used to screen for ETV1 gene rearrangements in a cohort of 429 prostate cancers from patients who…”
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Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma by WALLARD, M. J, PENNINGTON, C. J, KELLY, J. I. D, VEERAKUMARASIVAM, A, BURTT, G, MILLS, I. G, WARREN, A, LEUNG, H. Y, MURPHY, G, EDWARDS, D. R, NEAL, D. E

“…The matrix metalloproteinases (MMPs) are endopeptidases which break down the extracellular matrix and regulate cytokine and growth factor activity. Several…”
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The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance by Hepburn, A. C., Steele, R. E., Veeratterapillay, R., Wilson, L., Kounatidou, E. E., Barnard, A., Berry, P., Cassidy, J. R., Moad, M., El-Sherif, A., Gaughan, L., Mills, I. G., Robson, C. N., Heer, R.

“…Stem cell characteristics have been associated with treatment resistance and poor prognosis across many cancer types. The ability to induce and regulate the…”
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Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy by Jain, S., Lyons, C.A., Walker, S.M., McQuaid, S., Hynes, S.O., Mitchell, D.M., Pang, B., Logan, G.E., McCavigan, A.M., O’Rourke, D., McArt, D.G., McDade, S.S., Mills, I.G., Prise, K.M., Knight, L.A., Steele, C.J., Medlow, P.W., Berge, V., Katz, B., Loblaw, D.A., Harkin, D.P., James, J.A., O'sullivan, J.M., Kennedy, R.D., Waugh, D.J.

“…Radiotherapy is an effective treatment of intermediate/high-risk locally advanced prostate cancer, however, >30% of patients relapse within 5 years…”
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Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer by Richardsen, E., Andersen, S., Al-Saad, S., Rakaee, M., Nordby, Y., Pedersen, M. I., Ness, N., Ingebriktsen, L. M., Fassina, A., Taskén, K. A., Mills, I. G., Donnem, T., Bremnes, R. M., Busund, L. T.

“…Prostate cancer (PC) is a highly heterogenous disease and one of the leading causes of mortality in developed countries. Recently, studies have shown that…”
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Endosomal Localization and Receptor Dynamics Determine Tyrosine Phosphorylation of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate by Urbé, Sylvie, Mills, Ian G., Stenmark, Harald, Kitamura, Naomi, Clague, Michael J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human blood-based exposure levels of persistent organic pollutant (POP) mixtures antagonise androgen receptor transactivation and translocation by McComb, J., Mills, I.G., Muller, M., Berntsen, H.F., Zimmer, K.E., Ropstad, E., Verhaegen, S., Connolly, L.

“…Human exposure to persistent organic pollutants (POPs) has been linked to genitourinary health-related conditions such as decreased sperm quality, hypospadias,…”
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A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer by Fletcher, C E, Deng, L, Orafidiya, F, Yuan, W, Lorentzen, M P G S, Cyran, O W, Varela-Carver, A, Constantin, T A, Leach, D A, Dobbs, F M, Figueiredo, I, Gurel, B, Parkes, E, Bogdan, D, Pereira, R R, Zhao, S G, Neeb, A, Issa, F, Hester, J, Kudo, H, Liu, Y, Philippou, Y, Bristow, R, Knudsen, K, Bryant, R J, Feng, F Y, Reed, S H, Mills, I G, de Bono, J, Bevan, C L

“…miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate…”
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Cell cycle-coupled expansion of AR activity promotes cancer progression by McNair, C, Urbanucci, A, Comstock, C E S, Augello, M A, Goodwin, J F, Launchbury, R, Zhao, S G, Schiewer, M J, Ertel, A, Karnes, J, Davicioni, E, Wang, L, Wang, Q, Mills, I G, Feng, F Y, Li, W, Carroll, J S, Knudsen, K E

“…The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic…”
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Corrigendum to “Integration of Copy Number and Transcriptomics Provides Risk Stratification in Prostate Cancer: A Discovery and Validation Cohort Study” [EBioMedicine 2 (9) (2015) 1133–1144] by Ross-Adams, H., Lamb, A.D., Dunning, M.J., Halim, S., Lindberg, J., Massie, C.M., Egevad, L.A., Russell, R., Ramos-Montoya, A., Vowler, S.L., Sharma, N.L., Kay, J., Whitaker, H., Clark, J., Hurst, R., Gnanapragasam, V.J., Shah, N.C., Warren, A.Y., Cooper, C.S., Lynch, A.G., Stark, R., Mills, I.G., Grönberg, H., Neal, D.E.

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Correction: The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance by Hepburn, A. C., Steele, R. E., Veeratterapillay, R., Wilson, L., Kounatidou, E. E., Barnard, A., Berry, P., Cassidy, J. R., Moad, M., El-Sherif, A., Gaughan, L., Mills, I. G., Robson, C. N., Heer, R.

“…The original version of this article contained an error in Fig. 5a where the colours of the labels representing the Hinge and LBD of the AR were incorrect and…”
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MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3 by Saeb-Parsy, K, Veerakumarasivam, A, Wallard, M J, Thorne, N, Kawano, Y, Murphy, G, Neal, D E, Mills, I G, Kelly, J D

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Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro by McComb, J., Mills, I. G., Berntsen, Hanne Friis, Ropstad, E., Verhaegen, S., Connolly, L.

“…Perfluoroalkyl acids (PFAAs) are detectable in human blood. PFAA exposure may contribute to androgen receptor (AR)-related health effects such as prostate…”
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Pathogenesis of prostate cancer and hormone refractory prostate cancer by Girling, J S, Whitaker, H C, Mills, I G, Neal, D E

“…Prostate cancer is the second most common malignancy in males and the leading cause of cancer death. Prostate cancer is initially androgen dependent and relies…”
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Correction to: Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro by McComb, J., Mills, I. G., Berntsen, Hanne Friis, Ropstad, E., Verhaegen, S., Connolly, L.

“…The current title reads: Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components Androgen…”
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BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure by Peter, Brian J., Kent, Helen M., Mills, Ian G., Vallis, Yvonne, P. Jonathan G. Butler, Evans, Philip R., McMahon, Harvey T.

“…The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved…”
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The spatial landscape of clonal somatic mutations in benign and malignant prostate epithelia by Erickson, A.M., Berglund, E., He, M., Marklund, M., Mirzazadeh, R., Schultz, N., Bergenstråhle, L., Kvastad, L., Andersson, A., Bergenstråhle, J., Larsson, L., Rajakumar, T., Thrane, K., Ji, A.L., Tarish, F., Tanoglidi, A., Maaskola, J., Colling, R., Mirtti, T., Hamdy, F.C., Woodcock, D.J., Helleday, T., Mills, I.G., Lamb, A., Lundenberg, J.

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