Search Results - "Mills, H"

IL-17 and IL-17-producing cells in protection versus pathology by Mills, Kingston H. G.

“…IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology…”
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Immune checkpoints and their inhibition in cancer and infectious diseases by Dyck, Lydia, Mills, Kingston H.G.

“…The development of chronic infections and cancer is facilitated by a variety of immune subversion mechanisms, such as the production of anti‐inflammatory…”
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Multiplicity of dislocation pathways in a refractory multiprincipal element alloy by Wang, Fulin, Balbus, Glenn H., Xu, Shuozhi, Su, Yanqing, Shin, Jungho, Rottmann, Paul F., Knipling, Keith E., Stinville, Jean-Charles, Mills, Leah H., Senkov, Oleg N., Beyerlein, Irene J., Pollock, Tresa M., Gianola, Daniel S.

“…Pathways for ductility Alloys containing multiple elements can be very strong but often suffer from poor ductility. F. Wang et al. found that different…”
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How immunology can help reverse the pertussis vaccine failure by Mills, Kingston H. G.

“…Current acellular pertussis vaccines prevent disease but do not prevent nasal infection and transmission of Bordetella pertussis . However, immunology is…”
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Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells by McGinley, Aoife M., Sutton, Caroline E., Edwards, Sarah C., Leane, Charlotte M., DeCourcey, Joseph, Teijeiro, Ana, Hamilton, John A., Boon, Louis, Djouder, Nabil, Mills, Kingston H.G.

“…Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is…”
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Trained immunity: A program of innate immune memory in health and disease by Netea, Mihai G., Joosten, Leo A. B., Latz, Eicke, Mills, Kingston H. G., Natoli, Gioacchino, Stunnenberg, Hendrik G., O'Neill, Luke A. J., Xavier, Ramnik J.

“…The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in…”
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Metabolic reprogramming of natural killer cells in obesity limits antitumor responses by Michelet, Xavier, Dyck, Lydia, Hogan, Andrew, Loftus, Roisin M., Duquette, Danielle, Wei, Kevin, Beyaz, Semir, Tavakkoli, Ali, Foley, Cathriona, Donnelly, Raymond, O’Farrelly, Cliona, Raverdeau, Mathilde, Vernon, Ashley, Pettee, William, O’Shea, Donal, Nikolajczyk, Barbara S., Mills, Kingston H. G., Brenner, Michael B., Finlay, David, Lynch, Lydia

“…Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic…”
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Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases by Finlay, Conor M., Walsh, Kevin P., Mills, Kingston H. G.

“…Summary Helminth parasites are highly successful pathogens, chronically infecting a quarter of the world's population, causing significant morbidity but rarely…”
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IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory γδ T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice by Misiak, Alicja, Wilk, Mieszko M, Raverdeau, Mathilde, Mills, Kingston H G

“…γδ T cells play a role in protective immunity to infection at mucosal surface, but also mediate pathology in certain autoimmune diseases through innate IL-17…”
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The role of inflammasome-derived IL-1 in driving IL-17 responses by Mills, Kingston H. G., Dungan, Lara S., Jones, Sarah A., Harris, James

“…Review of the activation of inflammasome processes IL‐1β and IL‐18, which synergize with IL‐23 to promote IL‐17 production, by IL‐17‐secreting γδ T and Th17…”
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Adenosine receptor signaling modulates permeability of the blood-brain barrier by Carman, Aaron J, Mills, Jeffrey H, Krenz, Antje, Kim, Do-Geun, Bynoe, Margaret S

“…The blood-brain barrier (BBB) is comprised of specialized endothelial cells that form the capillary microvasculature of the CNS and is essential for brain…”
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TLR-dependent T cell activation in autoimmunity by Mills, Kingston H. G.

“…Key Points Toll-like receptors (TLRs) are members of the pattern recognition receptor (PRR) family. They sense pathogen-derived molecules termed…”
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Targeting Regulatory T Cells in Cancer by BYRNE, William L, MILLS, Kingston H. G, LEDERER, James A, O'SULLIVAN, Gerald C

“…Infiltration of tumors by regulatory T cells confers growth and metastatic advantages by inhibiting antitumor immunity and by production of receptor activator…”
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A guiding map for inflammation by Netea, Mihai G, Balkwill, Frances, Chonchol, Michel, Cominelli, Fabio, Donath, Marc Y, Giamarellos-Bourboulis, Evangelos J, Golenbock, Douglas, Gresnigt, Mark S, Heneka, Michael T, Hoffman, Hal M, Hotchkiss, Richard, Joosten, Leo A B, Kastner, Daniel L, Korte, Martin, Latz, Eicke, Libby, Peter, Mandrup-Poulsen, Thomas, Mantovani, Alberto, Mills, Kingston H G, Nowak, Kristen L, O'Neill, Luke A, Pickkers, Peter, van der Poll, Tom, Ridker, Paul M, Schalkwijk, Joost, Schwartz, David A, Siegmund, Britta, Steer, Clifford J, Tilg, Herbert, van der Meer, Jos W M, van de Veerdonk, Frank L, Dinarello, Charles A

“…Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in…”
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases by Coll, Rebecca C, Robertson, Avril A B, Chae, Jae Jin, Higgins, Sarah C, Muñoz-Planillo, Raúl, Inserra, Marco C, Vetter, Irina, Dungan, Lara S, Monks, Brian G, Stutz, Andrea, Croker, Daniel E, Butler, Mark S, Haneklaus, Moritz, Sutton, Caroline E, Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L, Mills, Kingston H G, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, O'Neill, Luke A J

“…A selective, small-molecule inhibitor of NLRP3 suppresses activation of the inflammasome in vitro and in vivo and attenuates inflammatory disease. The NOD-like…”
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Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine by Ross, Pádraig J, Sutton, Caroline E, Higgins, Sarah, Allen, Aideen C, Walsh, Kevin, Misiak, Alicja, Lavelle, Ed C, McLoughlin, Rachel M, Mills, Kingston H G

“…Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One…”
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Collapse of a fish population after exposure to a synthetic estrogen by Kidd, Karen A, Blanchfield, Paul J, Mills, Kenneth H, Palace, Vince P, Evans, Robert E, Lazorchak, James M, Flick, Robert W

“…Municipal wastewaters are a complex mixture containing estrogens and estrogen mimics that are known to affect the reproductive health of wild fishes. Male…”
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Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis by Wilk, Mieszko M, Misiak, Alicja, McManus, Róisín M, Allen, Aideen C, Lynch, Marina A, Mills, Kingston H G

“…Th1 and Th17 cells have an established role in protective immunity to , but this evidence is based largely on peripheral T cells. There is emerging evidence…”
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Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia by Campeau, Anaamika, Mills, Robert H., Stevens, Toer, Rossitto, Leigh-Ana, Meehan, Michael, Dorrestein, Pieter, Daly, Rebecca, Nguyen, Tanya T., Gonzalez, David J., Jeste, Dilip V., Hook, Vivian

“…Schizophrenia is a devastating psychiatric illness that detrimentally affects a significant portion of the worldwide population. Aging of schizophrenia…”
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CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis by Fletcher, Jean M, Lonergan, Roisin, Costelloe, Lisa, Kinsella, Katie, Moran, Barry, O'Farrelly, Cliona, Tubridy, Niall, Mills, Kingston H. G

“…Despite the fact that CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg cells) play a central role in maintaining self-tolerance and that IL-17-producing CD4(+) T…”
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