Search Results - "Mills, G. H."

IL-17 and IL-17-producing cells in protection versus pathology by Mills, Kingston H. G.

“…IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology…”
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Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases by Finlay, Conor M., Walsh, Kevin P., Mills, Kingston H. G.

“…Summary Helminth parasites are highly successful pathogens, chronically infecting a quarter of the world's population, causing significant morbidity but rarely…”
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The role of inflammasome-derived IL-1 in driving IL-17 responses by Mills, Kingston H. G., Dungan, Lara S., Jones, Sarah A., Harris, James

“…Review of the activation of inflammasome processes IL‐1β and IL‐18, which synergize with IL‐23 to promote IL‐17 production, by IL‐17‐secreting γδ T and Th17…”
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Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine by Ross, Pádraig J, Sutton, Caroline E, Higgins, Sarah, Allen, Aideen C, Walsh, Kevin, Misiak, Alicja, Lavelle, Ed C, McLoughlin, Rachel M, Mills, Kingston H G

“…Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One…”
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The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing by Cervantes-Silva, Mariana P., Carroll, Richard G., Wilk, Mieszko M., Moreira, Diana, Payet, Cloe A., O’Siorain, James R., Cox, Shannon L., Fagan, Lauren E., Klavina, Paula A., He, Yan, Drewinski, Tabea, McGinley, Alan, Buel, Sharleen M., Timmons, George A., Early, James O., Preston, Roger J. S., Hurley, Jennifer M., Finlay, David K., Schoen, Ingmar, Javier Sánchez-García, F., Mills, Kingston H. G., Curtis, Annie M.

“…Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many…”
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Targeting Regulatory T Cells in Cancer by BYRNE, William L, MILLS, Kingston H. G, LEDERER, James A, O'SULLIVAN, Gerald C

“…Infiltration of tumors by regulatory T cells confers growth and metastatic advantages by inhibiting antitumor immunity and by production of receptor activator…”
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Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance by Reynolds, Clare M., McGillicuddy, Fiona C., Harford, Karen A., Finucane, Orla M., Mills, Kingston H. G., Roche, Helen M.

“…Scope Inflammasome‐mediated inflammation is a critical regulator of obesity‐induced insulin resistance (IR). We hypothesized that saturated fatty acids (SFA)…”
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Non-invasive ventilation for weaning, avoiding reintubation after extubation and in the postoperative period: a meta-analysis by Glossop, A.J., Shepherd, N., Bryden, D.C., Mills, G.H.

“…Non-invasive ventilation (NIV) is a supportive therapy that improves mortality in acute respiratory failure (RF). It may also be used in patients recently…”
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Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma by McLoughlin, Rachel M., PhD, Mills, Kingston H.G., PhD

“…The human intestine contains more than 100 trillion microorganisms that maintain a symbiotic relationship with the host. Under normal conditions, these…”
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Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells by McGinley, Aoife M., Sutton, Caroline E., Edwards, Sarah C., Leane, Charlotte M., DeCourcey, Joseph, Teijeiro, Ana, Hamilton, John A., Boon, Louis, Djouder, Nabil, Mills, Kingston H.G.

“…Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is…”
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Protective role for caspase-11 during acute experimental murine colitis by Oficjalska, Katarzyna, Raverdeau, Mathilde, Aviello, Gabriella, Wade, Siobhan C, Hickey, Ana, Sheehan, Katherine M, Corr, Sinead C, Kay, Elaine W, O'Neill, Luke A, Mills, Kingston H G, Creagh, Emma M

“…Activation of the noncanonical inflammasome, mediated by caspase-11, serves as an additional pathway for the production of the proinflammatory cytokines IL-1β…”
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Improved survival in pregnancy and pulmonary hypertension using a multiprofessional approach by Kiely, DG, Condliffe, R, Webster, V, Mills, GH, Wrench, I, Gandhi, SV, Selby, K, Armstrong, IJ, Martin, L, Howarth, ES, Bu’Lock, FA, Stewart, P, Elliot, CA

“…Please cite this paper as: Kiely D, Condliffe R, Webster V, Mills G, Wrench I, Gandhi S, Selby K, Armstrong I, Martin L, Howarth E, Bu’Lock F, Stewart P,…”
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Trained immunity: A program of innate immune memory in health and disease by Netea, Mihai G., Joosten, Leo A. B., Latz, Eicke, Mills, Kingston H. G., Natoli, Gioacchino, Stunnenberg, Hendrik G., O'Neill, Luke A. J., Xavier, Ramnik J.

“…The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in…”
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Metabolic reprogramming of natural killer cells in obesity limits antitumor responses by Michelet, Xavier, Dyck, Lydia, Hogan, Andrew, Loftus, Roisin M., Duquette, Danielle, Wei, Kevin, Beyaz, Semir, Tavakkoli, Ali, Foley, Cathriona, Donnelly, Raymond, O’Farrelly, Cliona, Raverdeau, Mathilde, Vernon, Ashley, Pettee, William, O’Shea, Donal, Nikolajczyk, Barbara S., Mills, Kingston H. G., Brenner, Michael B., Finlay, David, Lynch, Lydia

“…Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic…”
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TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis: Role of IL-17-Producing T Cells by Higgins, Sarah C, Jarnicki, Andrew G, Lavelle, Ed C, Mills, Kingston H. G

“…Whole cell pertussis vaccines (Pw) induce Th1 responses and protect against Bordetella pertussis infection, whereas pertussis acellular vaccines (Pa) induce Ab…”
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Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet―Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis by MCGILLICUDDY, Fiona C, HARFORD, Karen A, REYNOLDS, Clare M, OLIVER, Elizabeth, CLAESSENS, Mandy, MILLS, Kingston H. G, ROCHE, Helen M

“…High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution of…”
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UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation by O'Connor, Emma B, Muñoz-Wolf, Natalia, Leon, Gemma, Lavelle, Ed C, Mills, Kingston H G, Walsh, Patrick T, Porter, Richard K

“…Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix…”
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Immune checkpoints and their inhibition in cancer and infectious diseases by Dyck, Lydia, Mills, Kingston H.G.

“…The development of chronic infections and cancer is facilitated by a variety of immune subversion mechanisms, such as the production of anti‐inflammatory…”
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases by Coll, Rebecca C, Robertson, Avril A B, Chae, Jae Jin, Higgins, Sarah C, Muñoz-Planillo, Raúl, Inserra, Marco C, Vetter, Irina, Dungan, Lara S, Monks, Brian G, Stutz, Andrea, Croker, Daniel E, Butler, Mark S, Haneklaus, Moritz, Sutton, Caroline E, Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L, Mills, Kingston H G, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, O'Neill, Luke A J

“…A selective, small-molecule inhibitor of NLRP3 suppresses activation of the inflammasome in vitro and in vivo and attenuates inflammatory disease. The NOD-like…”
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Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease by Brereton, Corinna F, Sutton, Caroline E, Lalor, Stephen J, Lavelle, Ed C, Mills, Kingston H. G

“…IL-17-producing CD4(+) T (Th17) cells are pathogenic in many autoimmune diseases. The induction and expansion of Th17 cells is directed by cytokines, including…”
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