Search Results - "Mills, G."

IL-17 and IL-17-producing cells in protection versus pathology by Mills, Kingston H. G.

“…IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology…”
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Maintaining and reprogramming genomic androgen receptor activity in prostate cancer by Mills, Ian G.

“…The androgen receptor (AR) regulates transcription networks and genomic stability. Selection pressures during prostate cancer development and therapy can…”
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Respiratory complications of anaesthesia by Mills, G. H.

“…Summary Postoperative pulmonary complications are a major determinant of outcome for patients and consume huge resources within hospital, particularly in…”
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Tropospheric ozone and its precursors from the urban to the global scale from air quality to short-lived climate forcer by Monks, P. S, Archibald, A. T, Colette, A, Cooper, O, Coyle, M, Derwent, R, Fowler, D, Granier, C, Law, K. S, Mills, G. E, Stevenson, D. S, Tarasova, O, Thouret, V, von Schneidemesser, E, Sommariva, R, Wild, O, Williams, M. L

“…Ozone holds a certain fascination in atmospheric science. It is ubiquitous in the atmosphere, central to tropospheric oxidation chemistry, yet harmful to human…”
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Thyroid Function Before, During, and After COVID-19 by Khoo, Bernard, Tan, Tricia, Clarke, Sophie A, Mills, Edouard G, Patel, Bijal, Modi, Manish, Phylactou, Maria, Eng, Pei Chia, Thurston, Layla, Alexander, Emma C, Meeran, Karim, Comninos, Alexander N, Abbara, Ali, Dhillo, Waljit S

“…Abstract Context The effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with both thyrotoxicosis and suppression…”
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The importance of DNA methylation in prostate cancer development by Massie, Charles E., Mills, Ian G., Lynch, Andy G.

“…•Many DNA methylation changes are observed between benign and cancerous prostate tissue.•DNA methylation changes are frequently early and recurrent, suggesting…”
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Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer by Abkevich, V, Timms, K M, Hennessy, B T, Potter, J, Carey, M S, Meyer, L A, Smith-McCune, K, Broaddus, R, Lu, K H, Chen, J, Tran, T V, Williams, D, Iliev, D, Jammulapati, S, FitzGerald, L M, Krivak, T, DeLoia, J A, Gutin, A, Mills, G B, Lanchbury, J S

“…Background: Defects in BRCA1 , BRCA2 , and other members of the homologous recombination pathway have potential therapeutic relevance when used to support…”
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Transfer of environmental microbes to the skin and respiratory tract of humans after urban green space exposure by Selway, Caitlin A., Mills, Jacob G., Weinstein, Philip, Skelly, Chris, Yadav, Sudesh, Lowe, Andrew, Breed, Martin F., Weyrich, Laura S.

“…•Microbes from urban green spaces may help to shape the human microbiome.•After urban green space exposure, skin and nasal microbial diversity increased.•Skin…”
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Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells by McGinley, Aoife M., Sutton, Caroline E., Edwards, Sarah C., Leane, Charlotte M., DeCourcey, Joseph, Teijeiro, Ana, Hamilton, John A., Boon, Louis, Djouder, Nabil, Mills, Kingston H.G.

“…Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is…”
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Trained immunity: A program of innate immune memory in health and disease by Netea, Mihai G., Joosten, Leo A. B., Latz, Eicke, Mills, Kingston H. G., Natoli, Gioacchino, Stunnenberg, Hendrik G., O'Neill, Luke A. J., Xavier, Ramnik J.

“…The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in…”
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Association between high serum total cortisol concentrations and mortality from COVID-19 by Tan, Tricia, Khoo, Bernard, Mills, Edouard G, Phylactou, Maria, Patel, Bijal, Eng, Pei C, Thurston, Layla, Muzi, Beatrice, Meeran, Karim, Prevost, A Toby, Comninos, Alexander N, Abbara, Ali, Dhillo, Waljit S

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Metabolic reprogramming of natural killer cells in obesity limits antitumor responses by Michelet, Xavier, Dyck, Lydia, Hogan, Andrew, Loftus, Roisin M., Duquette, Danielle, Wei, Kevin, Beyaz, Semir, Tavakkoli, Ali, Foley, Cathriona, Donnelly, Raymond, O’Farrelly, Cliona, Raverdeau, Mathilde, Vernon, Ashley, Pettee, William, O’Shea, Donal, Nikolajczyk, Barbara S., Mills, Kingston H. G., Brenner, Michael B., Finlay, David, Lynch, Lydia

“…Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic…”
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The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man by Sharma, Naomi L., Massie, Charlie E., Ramos-Montoya, Antonio, Zecchini, Vincent, Scott, Helen E., Lamb, Alastair D., MacArthur, Stewart, Stark, Rory, Warren, Anne Y., Mills, Ian G., Neal, David E.

“…The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commonest cancer in men in the UK. We present a comprehensive…”
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Chain Reduction of CHCl3 Photocatalyzed by SPEEK/PVA Films Swollen in Air-Saturated HCO2Na Solutions by Dissanayaka, Radini, Islam, Md Safiqul, Mills, G.

“…Thin cross-linked films containing sulfonated poly(ether etherketone), SPEEK, and poly(vinyl alcohol), PVA, served as efficient photocatalysts for the…”
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IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling by Sheng, Xia, Nenseth, Hatice Zeynep, Qu, Su, Kuzu, Omer F., Frahnow, Turid, Simon, Lukas, Greene, Stephanie, Zeng, Qingping, Fazli, Ladan, Rennie, Paul S., Mills, Ian G., Danielsen, Håvard, Theis, Fabian, Patterson, John B., Jin, Yang, Saatcioglu, Fahri

“…Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly…”
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The role of inflammasome-derived IL-1 in driving IL-17 responses by Mills, Kingston H. G., Dungan, Lara S., Jones, Sarah A., Harris, James

“…Review of the activation of inflammasome processes IL‐1β and IL‐18, which synergize with IL‐23 to promote IL‐17 production, by IL‐17‐secreting γδ T and Th17…”
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WUDAPT: An Urban Weather, Climate, and Environmental Modeling Infrastructure for the Anthropocene by Ching, J., Mills, G., Bechtel, B., See, L., Feddema, J., Wang, X., Ren, C., Brousse, O., Martilli, A., Neophytou, M., Mouzourides, P., Stewart, I., Hanna, A., Ng, E., Foley, M., Alexander, P., Aliaga, D., Niyogi, D., Shreevastava, A., Bhalachandran, P., Masson, V., Hidalgo, J., Fung, J., Andrade, M., Baklanov, A., Dai, W., Milcinski, G., Demuzere, M., Brunsell, N., Pesaresi, M., Miao, S., Mu, Q., Chen, F., Theeuwes, N.

“…The World Urban Database and Access Portal Tools (WUDAPT) is an international community-based initiative to acquire and disseminate climate relevant data on…”
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Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice by Liddicoat, Craig, Sydnor, Harrison, Cando-Dumancela, Christian, Dresken, Romy, Liu, Jiajun, Gellie, Nicholas J.C., Mills, Jacob G., Young, Jennifer M., Weyrich, Laura S., Hutchinson, Mark R., Weinstein, Philip, Breed, Martin F.

“…[Display omitted] •The effect of biodiverse aerobiomes on gut microbiota was previously untested.•We demonstrate that exposure to biodiverse soil dust…”
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Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine by Ross, Pádraig J, Sutton, Caroline E, Higgins, Sarah, Allen, Aideen C, Walsh, Kevin, Misiak, Alicja, Lavelle, Ed C, McLoughlin, Rachel M, Mills, Kingston H G

“…Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One…”
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O-GlcNAc Transferase - An Auxiliary Factor or a Full-blown Oncogene? by Itkonen, Harri M, Loda, Massimo, Mills, Ian G

“…The β-linked N-acetyl-d-glucosamine (GlcNAc) is a posttranslational modification of serine and threonine residues catalyzed by the enzyme O-GlcNAc transferase…”
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