Search Results - "Mills, Alea"

Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins by Mills, Alea A

“…Key Points Transcriptional programmes established during embryogenesis are transmitted to daughter cells of the adult so that each cell maintains its…”
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p63-related signaling at a glance by Fisher, Matthew L, Balinth, Seamus, Mills, Alea A

“…p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse…”
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The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer by Mills, Alea A

“…A plethora of mutations in chromatin regulators in diverse human cancers is emerging, attesting to the pivotal role of chromatin dynamics in tumorigenesis. A…”
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ΔNp63α in cancer: importance and therapeutic opportunities by Fisher, Matthew L., Balinth, Seamus, Mills, Alea A.

“…Our understanding of cancer and the key pathways that drive cancer survival has expanded rapidly over the past several decades. However, there are still…”
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Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4 by Rein, Benjamin, Tan, Tao, Yang, Fengwei, Wang, Wei, Williams, Jamal, Zhang, Freddy, Mills, Alea, Yan, Zhen

“…The human 16p11.2 gene locus is a hot spot for copy number variations, which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications…”
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The quest for the 1p36 tumor suppressor by Bagchi, Anindya, Mills, Alea A

“…Genomic analyses of late-stage human cancers have uncovered deletions encompassing 1p36, thereby providing an extensive body of literature supporting the idea…”
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BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network by Sun, Xueqin, Klingbeil, Olaf, Lu, Bin, Wu, Caizhi, Ballon, Carlos, Ouyang, Meng, Wu, Xiaoli S., Jin, Ying, Hwangbo, Yon, Huang, Yu-Han, Somerville, Tim D. D., Chang, Kenneth, Park, Jung, Chung, Taemoon, Lyons, Scott K., Shi, Junwei, Vogel, Hannes, Schulder, Michael, Vakoc, Christopher R., Mills, Alea A.

“…Inhibition of the tumour suppressive function of p53 (encoded by TP53 ) is paramount for cancer development in humans. However, p53 remains unmutated in the…”
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Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal Differentiation by Shrestha, Padmina, Jaganathan, Anbalagan, Huilgol, Dhananjay, Ballon, Carlos, Hwangbo, Yon, Mills, Alea A

“…Chromodomain helicase DNA-binding protein 5 (Chd5) is an ATP-dependent chromatin remodeler that promotes neuronal differentiation. However, the mechanism…”
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p63 regulates an adhesion programme and cell survival in epithelial cells by Brugge, Joan S, Carroll, Danielle K, Carroll, Jason S, Leong, Chee-Onn, Cheng, Fang, Brown, Myles, Mills, Alea. A, Ellisen, Leif W

“…p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates. By characterising transcriptional changes and…”
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FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis by Park, Eunmi, Kim, Hyungjin, Kim, Jung Min, Primack, Benjamin, Vidal-Cardenas, Sofia, Xu, Ye, Price, Brendan D., Mills, Alea A., D’Andrea, Alan D.

“…Fanconi anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the…”
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Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism by Horev, Guy, Ellegood, Jacob, Lerch, Jason P, Son, Young-Eun E, Muthuswamy, Lakshmi, Vogel, Hannes, Krieger, Abba M, Buja, Andreas, Henkelman, R. Mark, Wigler, Michael, Mills, Alea A

“…Recurrent copy number variations (CNVs) of human 16p11.2 have been associated with a variety of developmental/neurocognitive syndromes. In particular, deletion…”
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P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss by Stefanski, Heather E, Xing, Yan, Nicholls, Jemma, Jonart, Leslie, Goren, Emily, Taylor, Patricia A, Mills, Alea A, Riddle, Megan, McGrath, John, Tolar, Jakub, Hollander, Georg A, Blazar, Bruce R

“…Progressive immune deficiency of aging is characterized by severe thymic atrophy, contracted T cell repertoire, and poor immune function. p63 is critical for…”
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EZH2 regulates a SETDB1/ΔNp63α axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma by Balinth, Seamus, Fisher, Matthew L., Hwangbo, Yon, Wu, Caizhi, Ballon, Carlos, Sun, Xueqin, Mills, Alea A.

“…Enhancer of zeste homolog 2 (EZH2) and SET domain bifurcated 1 (SETDB1, also known as ESET) are oncogenic methyltransferases implicated in a number of human…”
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Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion by Tian, Di, Stoppel, Laura J, Heynen, Arnold J, Lindemann, Lothar, Jaeschke, Georg, Mills, Alea A, Bear, Mark F

“…Microdeletions of chromosome 16p11.2 can cause autism, but the pathogenic mechanisms remain unclear. Here the authors show that in a 16p11.2 mouse model,…”
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Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma by Fisher, Matthew L, Balinth, Seamus, Hwangbo, Yon, Wu, Caizhi, Ballon, Carlos, Goldberg, Gary L, Mills, Alea A

“…Abstract The chromobox-containing protein CBX4 is an important regulator of epithelial cell proliferation and differentiation, and has been implicated in…”
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Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model by Mills, Alea A, Gogos, Joseph A, Lai, Wen-Sung, Xu, Bin, Liu, Hui, Karayiorgou, Maria, Pavlidis, Paul, Wan, Xiang, Stark, Kimberly L, Bagchi, Anindya, Hsu, Ruby

“…Individuals with 22q11.2 microdeletions show behavioral and cognitive deficits and are at high risk of developing schizophrenia. We analyzed an engineered…”
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Altered synaptic transmission and maturation of hippocampal CA1 neurons in a mouse model of human chr16p11.2 microdeletion by Lu, Hung-Chi, Mills, Alea A, Tian, Di

“…The pathophysiology of neurodevelopmental disorders is often observed early in infancy and toddlerhood. Mouse models of syndromic disorders have provided…”
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BRD4 Regulates Transcription Factor ΔNp63α to Drive a Cancer Stem Cell Phenotype in Squamous Cell Carcinomas by Fisher, Matthew L, Balinth, Seamus, Hwangbo, Yon, Wu, Caizhi, Ballon, Carlos, Wilkinson, John E, Goldberg, Gary L, Mills, Alea A

“…Bromodomain containing protein 4 (BRD4) plays a critical role in controlling the expression of genes involved in development and cancer. Inactivation of BRD4…”
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Different regulation of limb development by p63 transcript variants by Kawata, Manabu, Taniguchi, Yuki, Mori, Daisuke, Yano, Fumiko, Ohba, Shinsuke, Chung, Ung-Il, Shimogori, Tomomi, Mills, Alea A, Tanaka, Sakae, Saito, Taku

“…The apical ectodermal ridge (AER), located at the distal end of each limb bud, is a key signaling center which controls outgrowth and patterning of the…”
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TAp63 induces senescence and suppresses tumorigenesis in vivo by Guo, Xuecui, Keyes, William M., Papazoglu, Cristian, Zuber, Johannes, Li, Wangzhi, Lowe, Scott W., Vogel, Hannes, Mills, Alea A.

“…TAp63, a splice variant of the p53 homologue p63, suppresses tumorigenesis in p53-null mice by mediating Ras oncogene-induced senescence. TAp63-mediated…”
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