Search Results - "Millot, Gael A"

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site by Letessier, Anne, Millot, Gaël A., Koundrioukoff, Stéphane, Lachagès, Anne-Marie, Vogt, Nicolas, Hansen, R. Scott, Malfoy, Bernard, Brison, Olivier, Debatisse, Michelle

“…The origins of fragility Some chromosomal locations, known as common fragile sites, are predisposed to breakage. These sites have pathological relevance…”
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High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura by Canales-Herrerias, Pablo, Crickx, Etienne, Broketa, Matteo, Sokal, Aurélien, Chenon, Guilhem, Azzaoui, Imane, Vandenberghe, Alexis, Perima, Angga, Iannascoli, Bruno, Richard-Le Goff, Odile, Castrillon, Carlos, Mottet, Guillaume, Sterlin, Delphine, Robbins, Ailsa, Michel, Marc, England, Patrick, Millot, Gael A, Eyer, Klaus, Baudry, Jean, Mahevas, Matthieu, Bruhns, Pierre

“…The major therapeutic goal for immune thrombocytopenic purpura (ITP) is to restore normal platelet counts using drugs to promote platelet production or by…”
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The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors by Balbino, Bianca, Herviou, Pauline, Godon, Ophélie, Stackowicz, Julien, Goff, Odile Richard-Le, Iannascoli, Bruno, Sterlin, Delphine, Brûlé, Sébastien, Millot, Gael A, Harris, Faith M, Voronina, Vera A, Nadeau, Kari C, Macdonald, Lynn E, Murphy, Andrew J, Bruhns, Pierre, Reber, Laurent L

“…Omalizumab is an anti-IgE monoclonal antibody (mAb) approved for the treatment of severe asthma and chronic spontaneous urticaria. Use of omalizumab is…”
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LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses by Sanchez David, Raul Y, Combredet, Chantal, Najburg, Valérie, Millot, Gael A, Beauclair, Guillaume, Schwikowski, Benno, Léger, Thibaut, Camadro, Jean-Michel, Jacob, Yves, Bellalou, Jacques, Jouvenet, Nolwenn, Tangy, Frédéric, Komarova, Anastassia V

“…The retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) RIG-I, MDA5, and LGP2 stimulate inflammatory and antiviral responses by sensing nonself RNA…”
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Genome-wide mapping of individual replication fork velocities using nanopore sequencing by Theulot, Bertrand, Lacroix, Laurent, Arbona, Jean-Michel, Millot, Gael A., Jean, Etienne, Cruaud, Corinne, Pellet, Jade, Proux, Florence, Hennion, Magali, Engelen, Stefan, Lemainque, Arnaud, Audit, Benjamin, Hyrien, Olivier, Le Tallec, Benoît

“…Little is known about replication fork velocity variations along eukaryotic genomes, since reference techniques to determine fork speed either provide no…”
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Belt and braces: Two escape ways to maintain the cassette reservoir of large chromosomal integrons by Richard, Egill, Darracq, Baptiste, Littner, Eloi, Millot, Gael A, Conte, Valentin, Cokelaer, Thomas, Engelstädter, Jan, Rocha, Eduardo P C, Mazel, Didier, Loot, Céline

“…Integrons are adaptive devices that capture, stockpile, shuffle and express gene cassettes thereby sampling combinatorial phenotypic diversity. Some integrons…”
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A guide for functional analysis of BRCA1 variants of uncertain significance by Millot, Gaël A., Carvalho, Marcelo A., Caputo, Sandrine M., Vreeswijk, Maaike P.G., Brown, Melissa A., Webb, Michelle, Rouleau, Etienne, Neuhausen, Susan L., Hansen, Thomas v. O., Galli, Alvaro, Brandão, Rita D., Blok, Marinus J., Velkova, Aneliya, Couch, Fergus J., Monteiro, Alvaro N.A.

“…Germline mutations in the tumor suppressor gene BRCA1 confer an estimated lifetime risk of 56–80% for breast cancer and 15–60% for ovarian cancer. Since the…”
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The Loss of Expression of a Single Type 3 Effector (CT622) Strongly Reduces Chlamydia trachomatis Infectivity and Growth by Cossé, Mathilde M, Barta, Michael L, Fisher, Derek J, Oesterlin, Lena K, Niragire, Béatrice, Perrinet, Stéphanie, Millot, Gaël A, Hefty, P Scott, Subtil, Agathe

“…Invasion of epithelial cells by the obligate intracellular bacterium results in its enclosure inside a membrane-bound compartment termed an inclusion. The…”
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Transcription-dependent regulation of replication dynamics modulates genome stability by Blin, Marion, Le Tallec, Benoît, Nähse, Viola, Schmidt, Mélanie, Brossas, Caroline, Millot, Gael A., Prioleau, Marie-Noëlle, Debatisse, Michelle

“…Common fragile sites (CFSs) are loci that are hypersensitive to replication stress and hotspots for chromosomal rearrangements in cancers. CFSs replicate late…”
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MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut by Marbouty, Martial, Thierry, Agnès, Millot, Gaël A, Koszul, Romain

“…Bacteriophages play important roles in regulating the intestinal human microbiota composition, dynamics, and homeostasis, and characterizing their bacterial…”
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Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage by Técher, Hervé, Koundrioukoff, Stéphane, Carignon, Sandra, Wilhelm, Therese, Millot, Gaël A., Lopez, Bernard S., Brison, Olivier, Debatisse, Michelle

“…Mammalian cells deficient in ATR or Chk1 display moderate replication fork slowing and increased initiation density, but the underlying mechanisms have…”
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Serpentine: a flexible 2D binning method for differential Hi-C analysis by Baudry, Lyam, Millot, Gaël A, Thierry, Agnes, Koszul, Romain, Scolari, Vittore F

“…Abstract Motivation Hi-C contact maps reflect the relative contact frequencies between pairs of genomic loci, quantified through deep sequencing. Differential…”
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Chlamydia trachomatis development requires both host glycolysis and oxidative phosphorylation but has only minor effects on these pathways by N’Gadjaga, Maimouna D., Perrinet, Stéphanie, Connor, Michael G., Bertolin, Giulia, Millot, Gaël A., Subtil, Agathe

“…The obligate intracellular bacteria Chlamydia trachomatis obtain all nutrients from the cytoplasm of their epithelial host cells and stimulate glucose uptake…”
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A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1 by Eloy, Philippine, Dehainault, Catherine, Sefta, Meriem, Aerts, Isabelle, Doz, François, Cassoux, Nathalie, Lumbroso le Rouic, Livia, Stoppa-Lyonnet, Dominique, Radvanyi, François, Millot, Gaël A, Gauthier-Villars, Marion, Houdayer, Claude

“…Retinoblastoma (Rb), the most common pediatric intraocular neoplasm, results from inactivation of both alleles of the RB1 tumor suppressor gene. The second…”
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Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers by Golmard, Lisa, Castéra, Laurent, Krieger, Sophie, Moncoutier, Virginie, Abidallah, Khadija, Tenreiro, Henrique, Laugé, Anthony, Tarabeux, Julien, Millot, Gael A, Nicolas, André, Laé, Marick, Abadie, Caroline, Berthet, Pascaline, Polycarpe, Florence, Frébourg, Thierry, Elan, Camille, de Pauw, Antoine, Gauthier-Villars, Marion, Buecher, Bruno, Stern, Marc-Henri, Stoppa-Lyonnet, Dominique, Vaur, Dominique, Houdayer, Claude

“…RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) have recently been involved in breast and ovarian cancer predisposition: RAD51B, RAD51C, and RAD51D…”
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Heritability of the melatonin synthesis variability in autism spectrum disorders by Benabou, Marion, Rolland, Thomas, Leblond, Claire S., Millot, Gaël A., Huguet, Guillaume, Delorme, Richard, Leboyer, Marion, Pagan, Cécile, Callebert, Jacques, Maronde, Erik, Bourgeron, Thomas

“…Autism Spectrum Disorders (ASD) are heterogeneous neurodevelopmental disorders with a complex genetic architecture. They are characterized by impaired social…”
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Functional Assessment of Genetic Variants with Outcomes Adapted to Clinical Decision-Making by Thouvenot, Pierre, Ben Yamin, Barbara, Fourrière, Lou, Lescure, Aurianne, Boudier, Thomas, Del Nery, Elaine, Chauchereau, Anne, Goldgar, David E, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Nicolas, Alain, Millot, Gaël A

“…Understanding the medical effect of an ever-growing number of human variants detected is a long term challenge in genetic counseling. Functional assays, based…”
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Single-molecule, antibody-free fluorescent visualisation of replication tracts along barcoded DNA molecules by De Carli, Francesco, Gaggioli, Vincent, Millot, Gaël A, Hyrien, Olivier

“…DNA combing is a standard technique to map DNA replication at the single molecule level. Typically, replicating DNA is metabolically labelled with nucleoside…”
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Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites by Loot, Céline, Millot, Gael A., Richard, Egill, Littner, Eloi, Vit, Claire, Lemoine, Frédéric, Néron, Bertrand, Cury, Jean, Darracq, Baptiste, Niault, Théophile, Lapaillerie, Delphine, Parissi, Vincent, Rocha, Eduardo P. C., Mazel, Didier

“…Integrons are genetic elements involved in bacterial adaptation which capture, shuffle and express genes encoding adaptive functions embedded in cassettes…”
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Mosaicism and prenatal diagnosis options: insights from retinoblastoma by Dehainault, Catherine, Golmard, Lisa, Millot, Gaël A, Charpin, Agathe, Laugé, Anthony, Tarabeux, Julien, Aerts, Isabelle, Cassoux, Nathalie, Stoppa-Lyonnet, Dominique, Gauthier-Villars, Marion, Houdayer, Claude

“…In sporadic cases, a post-zygotic mutational event signifies a somatic mosaicism in the affected child only, which implies that these mutations affect only a…”
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