Search Results - "Millman, R"

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells by Hogrebe, Nathaniel J., Augsornworawat, Punn, Maxwell, Kristina G., Velazco-Cruz, Leonardo, Millman, Jeffrey R.

“…Generation of pancreatic β cells from human pluripotent stem cells (hPSCs) holds promise as a cell replacement therapy for diabetes. In this study, we…”
Get full text

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation by Augsornworawat, Punn, Maxwell, Kristina G., Velazco-Cruz, Leonardo, Millman, Jeffrey R.

“…Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet organoids could provide an unlimited cell source for diabetes…”
Get full text

Generation of stem cell-derived β-cells from patients with type 1 diabetes by Millman, Jeffrey R., Xie, Chunhui, Van Dervort, Alana, Gürtler, Mads, Pagliuca, Felicia W., Melton, Douglas A.

“…We recently reported the scalable in vitro production of functional stem cell-derived β-cells (SC-β cells). Here we extend this approach to generate the first…”
Get full text

Generation of Functional Human Pancreatic β Cells In Vitro by Pagliuca, Felicia W., Millman, Jeffrey R., Gürtler, Mads, Segel, Michael, Van Dervort, Alana, Ryu, Jennifer Hyoje, Peterson, Quinn P., Greiner, Dale, Melton, Douglas A.

“…The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide an unprecedented cell source for drug discovery and cell…”
Get full text

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells by Velazco-Cruz, Leonardo, Song, Jiwon, Maxwell, Kristina G., Goedegebuure, Madeleine M., Augsornworawat, Punn, Hogrebe, Nathaniel J., Millman, Jeffrey R.

“…Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have generated insulin-producing cells resembling pancreatic β cells. While…”
Get full text

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice by Vegas, Arturo J, Veiseh, Omid, Gürtler, Mads, Millman, Jeffrey R, Pagliuca, Felicia W, Bader, Andrew R, Doloff, Joshua C, Li, Jie, Chen, Michael, Olejnik, Karsten, Tam, Hok Hei, Jhunjhunwala, Siddharth, Langan, Erin, Aresta-Dasilva, Stephanie, Gandham, Srujan, McGarrigle, James J, Bochenek, Matthew A, Hollister-Lock, Jennifer, Oberholzer, Jose, Greiner, Dale L, Weir, Gordon C, Melton, Douglas A, Langer, Robert, Anderson, Daniel G

“…When encapsulated with alginate derivatives that resist the foreign-body response, human embryonic stem cell–derived beta cells restore long-term normoglycemia…”
Get full text

Differentiated human stem cells resemble fetal, not adult, β cells by Hrvatin, Siniša, O'Donnell, Charles W., Deng, Francis, Millman, Jeffrey R., Pagliuca, Felicia Walton, Dilorio, Philip, Rezania, Alireza, Gifford, David K., Melton, Douglas A.

“…Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type, and one widely recognized goal is to make pancreatic β cells. To this…”
Get full text

Applications of iPSC-derived beta cells from patients with diabetes by Maxwell, Kristina G., Millman, Jeffrey R.

“…Improved stem cell-derived pancreatic islet (SC-islet) differentiation protocols robustly generate insulin-secreting β cells from patient induced pluripotent…”
Get full text

Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells by Schmidt, Mason D, Ishahak, Matthew, Augsornworawat, Punn, Millman, Jeffrey R

“…Diabetes cell replacement therapy has the potential to be transformed by human pluripotent stem cell-derived β cells (SC-β cells). However, the precise…”
Get full text

A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes by Wang, Xi, Maxwell, Kristina G, Wang, Kai, Bowers, Daniel T, Flanders, James A, Liu, Wanjun, Wang, Long-Hai, Liu, Qingsheng, Liu, Chengyang, Naji, Ali, Wang, Yong, Wang, Bo, Chen, Jing, Ernst, Alexander U, Melero-Martin, Juan M, Millman, Jeffrey R, Ma, Minglin

“…Transplantation of stem cell-derived β (SC-β) cells represents a promising therapy for type 1 diabetes (T1D). However, the delivery, maintenance, and retrieval…”
Get more information

Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial by Clarke, N.W., Ali, A., Ingleby, F.C., Hoyle, A., Amos, C.L., Attard, G., Brawley, C.D., Calvert, J., Chowdhury, S., Cook, A., Cross, W., Dearnaley, D.P., Douis, H., Gilbert, D., Gillessen, S., Jones, R.J., Langley, R.E., MacNair, A., Malik, Z., Mason, M.D., Matheson, D., Millman, R., Parker, C.C., Ritchie, A.W.S., Rush, H., Russell, J.M., Brown, J., Beesley, S., Birtle, A., Capaldi, L., Gale, J., Gibbs, S., Lydon, A., Nikapota, A., Omlin, A., O'Sullivan, J.M., Parikh, O., Protheroe, A., Rudman, S., Srihari, N.N., Simms, M., Tanguay, J.S., Tolan, S., Wagstaff, J., Wallace, J., Wylie, J., Zarkar, A., Sydes, M.R., Parmar, M.K.B., James, N.D.

“…STAMPEDE has previously reported that the use of upfront docetaxel improved overall survival (OS) for metastatic hormone naïve prostate cancer patients…”
Get full text

Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques by Hu, Xiaomeng, White, Kathy, Olroyd, Ari G., DeJesus, Rowena, Dominguez, Antonia A., Dowdle, William E., Friera, Annabelle M., Young, Chi, Wells, Frank, Chu, Elaine Y., Ito, Cade Ellis, Krishnapura, Harini, Jain, Surbhi, Ankala, Ramya, McGill, Trevor J., Lin, August, Egenberger, Kyla, Gagnon, Allison, Michael Rukstalis, J., Hogrebe, Nathaniel J., Gattis, Corie, Basco, Ron, Millman, Jeffrey R., Kievit, Paul, Davis, Mark M., Lanier, Lewis L., Connolly, Andrew J., Deuse, Tobias, Schrepfer, Sonja

“…Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a recipient’s immune system would abolish the requirement for…”
Get full text

Identification of unique cell type responses in pancreatic islets to stress by Maestas, Marlie M., Ishahak, Matthew, Augsornworawat, Punn, Veronese-Paniagua, Daniel A., Maxwell, Kristina G., Velazco-Cruz, Leonardo, Marquez, Erica, Sun, Jiameng, Shunkarova, Mira, Gale, Sarah E., Urano, Fumihiko, Millman, Jeffrey R.

“…Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing from human samples and studies using in vitro and in vivo models…”
Get full text

Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification by Augsornworawat, Punn, Hogrebe, Nathaniel J., Ishahak, Matthew, Schmidt, Mason D., Marquez, Erica, Maestas, Marlie M., Veronese-Paniagua, Daniel A., Gale, Sarah E., Miller, Julia R., Velazco-Cruz, Leonardo, Millman, Jeffrey R.

“…Insulin-producing β cells created from human pluripotent stem cells have potential as a therapy for insulin-dependent diabetes, but human pluripotent stem…”
Get full text

SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro by Velazco-Cruz, Leonardo, Goedegebuure, Madeleine M., Maxwell, Kristina G., Augsornworawat, Punn, Hogrebe, Nathaniel J., Millman, Jeffrey R.

“…Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell therapy. Human embryonic stem cells (hESCs) and human induced…”
Get full text

Single-cell transcriptome profiling reveals β cell maturation in stem cell-derived islets after transplantation by Augsornworawat, Punn, Maxwell, Kristina G., Velazco-Cruz, Leonardo, Millman, Jeffrey R.

Get full text

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells by Velazco-Cruz, Leonardo, Goedegebuure, Madeleine M, Millman, Jeffrey R

“…Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy…”
Get full text

Binaural summation of amplitude modulation involves weak interaural suppression by Baker, D. H., Vilidaite, G., McClarnon, E., Valkova, E., Bruno, A., Millman, R. E.

“…The brain combines sounds from the two ears, but what is the algorithm used to achieve this summation of signals? Here we combine psychophysical amplitude…”
Get full text

Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes by Goswami, Debkalpa, Domingo‐Lopez, Daniel A., Ward, Niamh A., Millman, Jeffrey R., Duffy, Garry P., Dolan, Eimear B., Roche, Ellen T.

“…Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently…”
Get full text

Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors by Velev, Orlin D, Millman, Jeffrey R, Bhatt, Ketan H, Prevo, Brian G

“…The miniaturization of chemical and biological processes in microfluidic devices and bioarrays is a major technological achievement. Microchips performing…”
Get full text