Search Results - "Millings, Elizabeth J."

ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression by Watanabe, Kazuhisa, Nakayama, Kazuhiro, Ohta, Satoshi, Tago, Kenji, Boonvisut, Supichaya, Millings, Elizabeth J., Fischer, Stuart G., LeDuc, Charles A., Leibel, Rudolph L., Iwamoto, Sadahiko

“…A diabetes susceptibility gene, immunoglobulin-like domain containing receptor 2 (Ildr2), encodes a transmembrane protein localized to the endoplasmic…”
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ILDR2 has a negligible role in hepatic steatosis by Millings, Elizabeth J, De Rosa, Maria Caterina, Fleet, Sarah, Watanabe, Kazuhisa, Rausch, Richard, Egli, Dieter, Li, Gen, Leduc, Charles A, Zhang, Yiying, Fischer, Stuart G, Leibel, Rudolph L

“…We have previously reported that Ildr2 knockdown via adenovirally-delivered shRNA causes hepatic steatosis in mice. In the present study we investigated…”
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ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis by Watanabe, Kazuhisa, Watson, Elizabeth, Cremona, Maria Laura, Millings, Elizabeth J, Lefkowitch, Jay H, Fischer, Stuart G, LeDuc, Charles A, Leibel, Rudolph L

“…Ildr2, a modifier of diabetes susceptibility in obese mice, is expressed in most organs, including islets and hypothalamus, with reduced levels in livers of…”
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Development of the First Low Nanomolar Liver Receptor Homolog‑1 Agonist through Structure-guided Design by Mays, Suzanne G, Flynn, Autumn R, Cornelison, Jeffery L, Okafor, C. Denise, Wang, Hongtao, Wang, Guohui, Huang, Xiangsheng, Donaldson, Heather N, Millings, Elizabeth J, Polavarapu, Rohini, Moore, David D, Calvert, John W, Jui, Nathan T, Ortlund, Eric A

“…As a key regulator of metabolism and inflammation, the orphan nuclear hormone receptor, liver receptor homolog-1 (LRH-1), has potential as a therapeutic target…”
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A phospholipid mimetic targeting LRH-1 ameliorates colitis by Mays, Suzanne G, D'Agostino, Emma H, Flynn, Autumn R, Huang, Xiangsheng, Wang, Guohui, Liu, Xu, Millings, Elizabeth J, Okafor, C Denise, Patel, Anamika, Cato, Michael L, Cornelison, Jeffery L, Melchers, Diana, Houtman, René, Moore, David D, Calvert, John W, Jui, Nathan T, Ortlund, Eric A

“…Phospholipids are ligands for nuclear hormone receptors (NRs) that regulate transcriptional programs relevant to normal physiology and disease. Here, we…”
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ILDR2 Alters Hepatic Phospholipid Composition via MBOAT7—Effects on Liver Fat by WATANABE, KAZUHISA, NAKAYAMA, KAZUHIRO, YOSHIDA, KEN, MILLINGS, ELIZABETH J., LEDUC, CHARLES A., LEIBEL, RUDOLPH, IWAMOTO, SADAHIKO

“…Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes, and increases the risk for liver cirrhosis and cancer. A diabetes…”
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Investigating the Role of ILDR2 in Hepatic Lipid Metabolism and Pancreas Islet Function by Millings, Elizabeth J

“…Metabolic syndrome defines a cluster of related comorbidities including obesity, Type 2 diabetes, fatty liver disease, and cardiovascular diseases…”
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