Search Results - "Milligan, John F"

Current concepts in antisense drug design by Milligan, John F, Matteucci, Mark D, Martin, John C

“…Antisense oligodeoxynucleotides (ODNs) have been proposed as a major class of new pharmaceuticals. In general, antisense refers to the use of small, synthetic…”
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Determination of RNA-protein contacts using thiophosphate substitutions by Milligan, John F, Uhlenbeck, Olke C

“…The binding of the bacteriophage R17 coat protein to its RNA binding site is an example of a specific RNA-protein interaction. Extensive analysis has revealed…”
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Synthesis and binding properties of pyrimidine oligodeoxynucleoside analogs containing neutral phosphodiester replacements: the formacetal and 3'-thioformacetal internucleoside linkages by Jones, Robert J, Lin, Kuei Ying, Milligan, John F, Wadwani, Shalini, Matteucci, Mark D

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Oligonucleotides containing a covalent conformationally restricted phosphodiester analog for high-affinity triple helix formation: the riboacetal internucleotide linkage by Jones, Robert J, Swaminathan, S, Milligan, John F, Wadwani, Shalini, Froehler, Brian C, Matteucci, Mark D

“…The high-affinity, sequence-specific recognition of duplex (ds) DNA is an area of biological and chemical interest. Oligonucleotides (ONs) have been shown to…”
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Synthesis of small RNAs using T7 RNA polymerase by Milligan, J F, Uhlenbeck, O C

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Site and Mechanism of Antisense Inhibition by C-5 Propyne Oligonucleotides by Moulds, Courtney, Lewis, Jason G, Froehler, Brian C, Grant, Deborah, Huang, Teresa, Milligan, John F, Matteucci, Mark D, Wagner, Richard W

“…Antisense gene inhibition occurs when an oligonucleotide (ON) has sufficient binding affinity such that it hybridizes its reverse complementary target RNA and…”
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Oligonucleotide-Mediated Triple Helix Formation Using an N3-Protonated Deoxycytidine Analog Exhibiting pH-Independent Binding Within the Physiological Range by Krawczyk, Steven H., Milligan, John F., Wadwani, Shalini, Moulds, Courtney, Froehler, Brian C., Matteucci, Mark D.

“…Triple helix formation with pyrimidine deoxyoligonucleotides for the sequence-specific recognition of DNA duplex targets suffers from a decrease in affinity as…”
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Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates by MILLIGAN, J. F, GROEBE, D. R, WITHERELL, G. W, UHLENBECK, O. C

“…A method is described to synthesize small RNAs of defined length and sequence using T7 RNA polymerase and templates of synthetic DNA which contain the T7…”
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An anti-parallel triple helix motif with oligodeoxynucleotidescontaining 2'-deoxyguanosine and 7-deaza-2'-deoxy xanthosine by Milligan, John F., Krawazyk, Stevan H., Wadwani, Shalini, Matteucci, Mark D.

“…Triple helix formation of oligodeoxynucleotides (ODNs) with a 15 base pair poly-purine DNA target in the HER2 promoter was examined by footprinting analysis…”
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Triple helix DNA alters nucleosomal histone-DNA interactions and acts as a nucleosome barrier by Westin, Lorelei, Blomquist, Patrik, Milligan, John F., Wrange, Örjan

“…Oligonucleotides which form triple helical complexes on double-stranded DNA have been previously reported to selectively inhibit transcription both In vitro…”
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Development of antisense therapeutics. Implications for cancer gene therapy by Milligan, J F, Jones, R J, Froehler, B C, Matteucci, M D

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Specific, high-efficiency, triple-helix-mediated cross-linking to duplex DNA by Shaw, Jeng Pyng, Milligan, John, Krawczyk, Steven H, Matteucci, Mark

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