Search Results - "Milligan, James A"

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy by Myers, Robert W., Guan, Hong-Ping, Ehrhart, Juliann, Petrov, Aleksandr, Prahalada, Srinivasa, Tozzo, Effie, Yang, Xiaodong, Kurtz, Marc M., Trujillo, Maria, Trotter, Dinko Gonzalez, Feng, Danqing, Xu, Shiyao, Eiermann, George, Holahan, Marie A., Rubins, Daniel, Conarello, Stacey, Niu, Xiaoda, Souza, Sandra C., Miller, Corin, Liu, Jinqi, Lu, Ku, Feng, Wen, Li, Ying, Painter, Ronald E., Milligan, James A., He, Huaibing, Liu, Franklin, Ogawa, Aimie, Wisniewski, Douglas, Rohm, Rory J., Wang, Liyang, Bunzel, Michelle, Qian, Ying, Zhu, Wei, Wang, Hongwu, Bennet, Bindu, Scheuch, Lisa LaFranco, Fernandez, Guillermo E., Li, Cai, Klimas, Michael, Zhou, Gaochao, van Heek, Margaret, Biftu, Tesfaye, Weber, Ann, Kelley, David E., Thornberry, Nancy, Erion, Mark D., Kemp, Daniel M., Sebhat, Iyassu K.

“…5′-Adenosine monophosphate–activated protein kinase (AMPK) is a master regulator of energy homeostasis in eukaryotes. Despite three decades of investigation,…”
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Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P 1) receptor by Vachal, Petr, Toth, Leslie M., Hale, Jeffrey J., Yan, Lin, Mills, Sander G., Chrebet, Gary L., Koehane, Carol A., Hajdu, Richard, Milligan, James A., Rosenbach, Mark J., Mandala, Suzanne

“…Novel series of sphingosine-1-phosphate (S1P) receptor agonists were developed through a systematic SAR aimed to achieve high selectivity for a single member…”
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Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720 by Hale, Jeffrey J., Yan, Lin, Neway, William E., Hajdu, Richard, Bergstrom, James D., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary L., Thornton, Rosemary A., Card, Deborah, Rosenbach, Mark, HughRosen, Mandala, Suzanne

“…[Display omitted] The novel immunosuppressive agent FTY720 (1) is phosphorylated in vivo in a variety of species yielding an active metabolite that is an…”
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Discovery of N‑[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia by Debenham, John S, Madsen-Duggan, Christina, Clements, Matthew J, Walsh, Thomas F, Kuethe, Jeffrey T, Reibarkh, Mikhail, Salowe, Scott P, Sonatore, Lisa M, Hajdu, Richard, Milligan, James A, Visco, Denise M, Zhou, Dan, Lingham, Russell B, Stickens, Dominique, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Pang, Jianmei, Miller, Randy R, Sherer, Edward C, Hale, Jeffrey J

“…The discovery of novel 4-hydroxy-2-(heterocyclic)­pyrimidine-5-carboxamide inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) is described…”
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1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia by Vachal, Petr, Miao, Shouwu, Pierce, Joan M, Guiadeen, Deodial, Colandrea, Vincent J, Wyvratt, Matthew J, Salowe, Scott P, Sonatore, Lisa M, Milligan, James A, Hajdu, Richard, Gollapudi, Anantha, Keohane, Carol A, Lingham, Russell B, Mandala, Suzanne M, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Steinhuebel, Dietrich, Kieczykowski, Gerard R, Fleitz, Fred J, Chapman, Kevin, Athanasopoulos, John, Adam, Gregory, Akyuz, Can D, Jena, Dhirendra K, Lusen, Jeffrey W, Meng, Juncai, Stein, Benjamin D, Xia, Lei, Sherer, Edward C, Hale, Jeffrey J

“…The discovery of 1,3,8-triazaspiro[4.5]­decane-2,4-diones (spirohydantoins) as a structural class of pan-inhibitors of the prolyl hydroxylase (PHD) family of…”
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Utilizing Low-Volume Aqueous Acoustic Transfer with the Echo 525 to Enable Miniaturization of qRT-PCR Assay by Agrawal, Sony, Cifelli, Steven, Johnstone, Richard, Pechter, David, Barbey, Deborah A., Lin, Karen, Allison, Tim, Agrawal, Shree, Rivera-Gines, Aida, Milligan, James A., Schneeweis, Jonathan, Houle, Kevin, Struck, Alice J., Visconti, Richard, Sills, Matthew, Wildey, Mary Jo

“…Quantitative reverse transcription PCR (qRT-PCR) is a valuable tool for characterizing the effects of inhibitors on viral replication. The amplification of…”
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Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3 by Li, Zhen, Chen, Weirong, Hale, Jeffrey J, Lynch, Christopher L, Mills, Sander G, Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J, Milligan, James A, Shei, Gan-Ju, Chrebet, Gary, Parent, Stephen A, Bergstrom, James, Card, Deborah, Forrest, Michael, Quackenbush, Elizabeth J, Wickham, L. Alexandra, Vargas, Hugo, Evans, Rose M, Rosen, Hugh, Mandala, Suzanne

“…A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal…”
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A Rational Utilization of High-Throughput Screening Affords Selective, Orally Bioavailable 1-Benzyl-3-carboxyazetidine Sphingosine-1-phosphate-1 Receptor Agonists by Hale, Jeffrey J, Lynch, Christopher L, Neway, William, Mills, Sander G, Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J, Milligan, James A, Shei, Gan-Ju, Parent, Stephen A, Chrebet, Gary, Bergstrom, James, Card, Deborah, Ferrer, Marc, Hodder, Peter, Strulovici, Berta, Rosen, Hugh, Mandala, Suzanne

“…Moderately potent, selective S1P1 receptor agonists identified from high-throughput screening have been adapted into lipophilic tails for a class of orally…”
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SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with enhanced pharmacokinetic properties by Yan, Lin, Huo, Pei, Hale, Jeffrey J., Mills, Sander G., Hajdu, Richard, Keohane, Carol A., Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Mandala, Suzanne M.

“…Structure–activity relationship (SAR) studies of 3-arylpropionic acids—a class of novel S1P 1 selective agonists—by introducing substitution to the propionic…”
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Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with high selectivity against all other known S1P receptor subtypes by Yan, Lin, Huo, Pei, Doherty, George, Toth, Lesile, Hale, Jeffrey J., Mills, Sander G., Hajdu, Richard, Keohane, Carol A., Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Quackenbush, Elizabeth, Wickham, Alexandra, Mandala, Suzanne M.

“…A series of 3-arylpropionic acids were synthesized as potent and orally bioavailable S1P 1 receptor agonists that were highly selective against other S1P…”
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors by Yan, Lin, Budhu, Richard, Huo, Pei, Lynch, Christopher L., Hale, Jeffrey J., Mills, Sander G., Hajdu, Richard, Keohane, Carol A., Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Mandala, Suzanne M.

“…A series of 2-aryl(pyrrolidine-4-yl)acetic acids (e.g., 22g) were synthesized and evaluated as S1P receptor agonists and were found to lower peripheral…”
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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists by Colandrea, Vincent J., Legiec, Irene E., Huo, Pei, Yan, Lin, Hale, Jeffrey J., Mills, Sander G., Bergstrom, James, Card, Deborah, Chebret, Gary, Hajdu, Richard, Keohane, Carol Ann, Milligan, James A., Rosenbach, Mark J., Shei, Gan-Ju, Mandala, Suzanne M.

“…A series of 2-aryl(pyrrolidine-5-yl)acetic acids (e.g., 21) were synthesized and evaluated as S1P receptor agonists. Compounds 15– 21 were identified with good…”
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Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors by Yan, Lin, Hale, Jeffrey J., Lynch, Christopher L., Budhu, Richard, Gentry, Amy, Mills, Sander G., Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Rosen, Hugh, Mandala, Suzanne M.

“…A series of conformationally constrained analogs of 3 were synthesized and evaluated as S1P receptor agonists. Several novel scaffolds were identified as…”
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Assessment of blood pressure in cats presented with urethral obstruction by Malouin, Annie, Milligan, James A., Drobatz, Kenneth J.

“…Objective: To determine the arterial blood pressure at presentation in male cats with acute urethral obstruction, and to determine whether there was any…”
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Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1Preceptor subtypes by LIN YAN, PEI HUO, SHEI, Gan-Ju, CHREBET, Gary, BERGSTROM, James, CARD, Deborah, QUACKENBUSH, Elizabeth, WICKHAM, Alexandra, MANDALA, Suzanne M, DOHERTY, George, TOTH, Lesile, HALE, Jeffrey J, MILLS, Sander G, HAJDU, Richard, KEOHANE, Carol A, ROSENBACH, Mark J, MILLIGAN, James A

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Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P 1 ) Receptor Agonists with Exceptional Selectivity against S1P 2 and S1P 3 by Li, Zhen, Chen, Weirong, Hale, Jeffrey J., Lynch, Christopher L., Mills, Sander G., Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Parent, Stephen A., Bergstrom, James, Card, Deborah, Forrest, Michael, Quackenbush, Elizabeth J., Wickham, L. Alexandra, Vargas, Hugo, Evans, Rose M., Rosen, Hugh, Mandala, Suzanne

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The Power of Missouri Telephone Corporations to Increase Their Capital Stock and to Sell Such Increase at Less Than the Par Value by Milligan, James A

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