Search Results - "Milligan, Erin D."

Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management by Vanderwall, Arden G, Milligan, Erin D

“…Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between…”
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Pathological and protective roles of glia in chronic pain by Milligan, Erin D, Watkins, Linda R

“…Key Points Pain processing involves neurons, microglia and astrocytes. The functions of glia extend beyond basic support for neurons. Once activated, they…”
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Lifelong Impacts of Moderate Prenatal Alcohol Exposure on Neuroimmune Function by Noor, Shahani, Milligan, Erin D

“…alcohol exposure is emerging as a major risk factor for lifelong aberrant neuroimmune function. Fetal alcohol spectrum disorder encompasses a range of…”
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Independent and Combined Effects of Prenatal Alcohol Exposure and Prenatal Stress on Fetal HPA Axis Development by Bakhireva, Ludmila N, Solomon, Elizabeth, Roberts, Melissa H, Ma, Xingya, Rai, Rajani, Wiesel, Alexandria, Jacobson, Sandra W, Weinberg, Joanne, Milligan, Erin D

“…Prenatal alcohol exposure (PAE) and prenatal stress (PS) are highly prevalent conditions known to affect fetal programming of the…”
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Prenatal alcohol exposure alters mRNA expression for stress peptides, glucocorticoid receptor function and immune factors in acutely stressed neonatal brain by Ruffaner-Hanson, Chaselyn D, Fernandez-Oropeza, Annette K, Sun, Melody S, Caldwell, Kevin K, Allan, Andrea M, Savage, Daniel D, Valenzuela, C Fernando, Noor, Shahani, Milligan, Erin D

“…The amygdala, hippocampus and hypothalamus are critical stress regulatory areas that undergo functional maturation for stress responding initially established…”
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Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy by Noor, Shahani, Pritha, Ariana N, Pasmay, Andrea A, Sanchez, Jacob E, Sanchez, Joshua J, Fernandez-Oropeza, Annette K, Sun, Melody S, Dell'Orco, Michela, Davies, Suzy, Savage, Daniel D, Mellios, Nikolaos, Milligan, Erin D

“…Alcohol consumption during pregnancy is associated with Fetal Alcohol Spectrum Disorders (FASD) that results in a continuum of central nervous system (CNS)…”
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Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation by Ledeboer, Annemarie, Sloane, Evan M., Milligan, Erin D., Frank, Matthew G., Mahony, John H., Maier, Steven F., Watkins, Linda R.

“…Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating enhanced pain states by releasing proinflammatory cytokines…”
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The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions by Noor, Shahani, Sanchez, Joshua J., Sun, Melody S., Pervin, Zinia, Sanchez, Jacob E., Havard, Mara A., Epler, Lauren T., Nysus, Monique V., Norenberg, Jeffrey P., Wagner, Carston R., Davies, Suzy, Wagner, Jennifer L., Savage, Daniel D., Jantzie, Lauren L., Mellios, Nikolaos, Milligan, Erin D.

“…•Prenatal alcohol exposure (PAE) creates a risk of neuropathic pain in female rats.•Enhanced T cell proinflammatory factors are observed in PAE nerve-injured…”
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Prenatal alcohol exposure potentiates chronic neuropathic pain, spinal glial and immune cell activation and alters sciatic nerve and DRG cytokine levels by Noor, Shahani, Sanchez, Joshua J, Vanderwall, Arden G, Sun, Melody S, Maxwell, Jessie R, Davies, Suzy, Jantzie, Lauren L, Petersen, Timothy R, Savage, Daniel D, Milligan, Erin D

“…Highlights • Moderate prenatal alcohol exposure (PAE) potentiates chronic neuropathic pain. • PAE induces exaggerated spinal glial activation following…”
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Prenatal alcohol exposure is a risk factor for adult neuropathic pain via aberrant neuroimmune function by Sanchez, Joshua J, Noor, Shahani, Davies, Suzy, Savage, Daniel, Milligan, Erin D

“…Clinical studies show that prenatal alcohol exposure (PAE) results in effects that persist into adulthood. Experimental animal models of moderate PAE…”
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CXCR2 Blockade Mitigates Neural Cell Injury Following Preclinical Chorioamnionitis by Yellowhair, Tracylyn R, Newville, Jessie C, Noor, Shahani, Maxwell, Jessie R, Milligan, Erin D, Robinson, Shenandoah, Jantzie, Lauren L

“…Minimizing central nervous system (CNS) injury from preterm birth depends upon identification of the critical pathways that underlie essential…”
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Glial activation: a driving force for pathological pain by Watkins, Linda R., Milligan, Erin D., Maier, Steven F.

“…Pain is classically viewed as being mediated solely by neurons, as are other sensory phenomena. The discovery that spinal cord glia (microglia and astrocytes)…”
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Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids by Watkins, Linda R, Hutchinson, Mark R, Ledeboer, Annemarie, Wieseler-Frank, Julie, Milligan, Erin D, Maier, Steven F

“…Abstract Within the past decade, there has been increasing recognition that glia are far more than simply “housekeepers” for neurons. This review explores two…”
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Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels by Wilkerson, Jenny L., Gentry, Katherine R., Dengler, Ellen C., Wallace, James A., Kerwin, Audra A., Armijo, Leisha M., Kuhn, Megan N., Thakur, Ganesh A., Makriyannis, Alexandros, Milligan, Erin D.

“…Spinal AM1710 suppresses allodynia with corresponding anti-inflammatory and anti-MAGL (monoacylglycerol lipase) effects in the spinal cord and dorsal root…”
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Spinal Glia and Proinflammatory Cytokines Mediate Mirror-Image Neuropathic Pain in Rats by Milligan, Erin D, Twining, Carin, Chacur, Marucia, Biedenkapp, Joseph, O'Connor, Kevin, Poole, Stephen, Tracey, Kevin, Martin, David, Maier, Steven F, Watkins, Linda R

“…Mirror-image allodynia is a mysterious phenomenon that occurs in association with many clinical pain syndromes. Allodynia refers to pain in response to light…”
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Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions by Verge, Gail M., Milligan, Erin D., Maier, Steve F., Watkins, Linda R., Naeve, Gregory S., Foster, Alan C.

“…Fractalkine is a unique chemokine reported to be constitutively expressed by neurons. Its only receptor, CX3CR1, is expressed by microglia. Little is known…”
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A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine by Johnston, Ian N, Milligan, Erin D, Wieseler-Frank, Julie, Frank, Matthew G, Zapata, Varlin, Campisi, Jay, Langer, Stephen, Martin, David, Green, Paula, Fleshner, M, Leinwand, Leslie, Maier, Steven F, Watkins, Linda R

“…The present experiments examined the role of spinal proinflammatory cytokines [interleukin-1beta (IL-1)] and chemokines (fractalkine) in acute analgesia and in…”
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Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats by Ledeboer, Annemarie, Jekich, Brian M, Sloane, Evan M, Mahoney, John H, Langer, Stephen J, Milligan, Erin D, Martin, David, Maier, Steven F, Johnson, Kirk W, Leinwand, Leslie A, Chavez, Raymond A, Watkins, Linda R

“…Abstract Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful peripheral neuropathies. The mechanisms underlying this…”
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Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain by Wilkerson, Jenny L., Alberti, Lauren B., Kerwin, Audra A., Ledent, Catherine A., Thakur, Ganesh A., Makriyannis, Alexandros, Milligan, Erin D.

“…The CB2R agonist AM1710, examined in animal models of peripheral neuropathy, is effective in controlling aberrant light touch sensitivity, referred to as…”
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Spinal interleukin-10 therapy to treat peripheral neuropathic pain by Milligan, Erin D, Penzkover, Kathryn R, Soderquist, Ryan G, Mahoney, Melissa J

“…Current research indicates that chronic peripheral neuropathic pain includes a role for glia and the actions of proinflammatory factors. This review briefly…”
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