Search Results - "Milligan, E."

Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin by Gage, BF, Eby, C, Johnson, JA, Deych, E, Rieder, MJ, Ridker, PM, Milligan, PE, Grice, G, Lenzini, P, Rettie, AE, Aquilante, CL, Grosso, L, Marsh, S, Langaee, T, Farnett, LE, Voora, D, Veenstra, DL, Glynn, RJ, Barrett, A, McLeod, HL

“…Initiation of warfarin therapy using trial‐and‐error dosing is problematic. Our goal was to develop and validate a pharmacogenetic algorithm. In the derivation…”
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Clinical classification schemes for predicting hemorrhage: Results from the National Registry of Atrial Fibrillation (NRAF) by Gage, Brian F., Yan, Yan, Milligan, Paul E., Waterman, Amy D., Culverhouse, Robert, Rich, Michael W., Radford, Martha J.

“…Although warfarin and other anticoagulants can prevent ischemic events, they can cause hemorrhage. Quantifying the rate of hemorrhage is crucial for…”
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The Endocannabinoid System and Oligodendrocytes in Health and Disease by Ilyasov, Alexander A, Milligan, Carolanne E, Pharr, Emily P, Howlett, Allyn C

“…Cannabinoid-based interventions are being explored for central nervous system (CNS) pathologies such as neurodegeneration, demyelination, epilepsy, stroke, and…”
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Regulation of heat shock protein 70 release in astrocytes: Role of signaling kinases by Taylor, Anna R., Robinson, Mac B., Gifondorwa, David J., Tytell, Michael, Milligan, Carolanne E.

“…The ability to mount a successful stress response in the face of injury is critical to the long‐term viability of individual cells and to the organism in…”
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Complete Dissociation of Motor Neuron Death from Motor Dysfunction by Bax Deletion in a Mouse Model of ALS by Gould, Thomas W, Buss, Robert R, Vinsant, Sharon, Prevette, David, Sun, Woong, Knudson, C. Michael, Milligan, Carol E, Oppenheim, Ronald W

“…The death of cranial and spinal motoneurons (MNs) is believed to be an essential component of the pathogenesis of amyotrophic lateral sclerosis (ALS). We…”
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Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing by Lenzini, P, Wadelius, M, Kimmel, S, Anderson, J L, Jorgensen, A L, Pirmohamed, M, Caldwell, M D, Limdi, N, Burmester, J K, Dowd, M B, Angchaisuksiri, P, Bass, A R, Chen, J, Eriksson, N, Rane, A, Lindh, J D, Carlquist, J F, Horne, B D, Grice, G, Milligan, P E, Eby, C, Shin, J, Kim, H, Kurnik, D, Stein, C M, McMillin, G, Pendleton, R C, Berg, R L, Deloukas, P, Gage, B F

“…Well‐characterized genes that affect warfarin metabolism (cytochrome P450 (CYP) 2C9) and sensitivity (vitamin K epoxide reductase complex 1 (VKORC1)) explain…”
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The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture by Sanchez, J.E., Noor, S., Sun, M.S., Zimmerly, J., Pasmay, A., Sanchez, J.J., Vanderwall, A.G., Haynes, M.K., Sklar, L.A., Escalona, P.R., Milligan, E.D.

“…•Pramipexole and dexpramipexole are anti-inflammatory agents and induce anti-allodynia.•Pramipexole directly blunts IL-1β protein levels in human stimulated…”
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An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine by Milligan, E., Zapata, V., Schoeniger, D., Chacur, M., Green, P., Poole, S., Martin, D., Maier, S. F., Watkins, L. R.

“…Fractalkine is a chemokine that is tethered to the extracellular surface of neurons. Fractalkine can be released, forming a diffusible signal. Spinal…”
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Glia in pathological pain: A role for fractalkine by Milligan, E.D, Sloane, E.M, Watkins, L.R

“…Abstract Microglia and/or astrocytes play a significant role in the creation and maintenance of exaggerated pain states with inflammatory and/or neuropathic…”
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Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats by Milligan, E. D., Zapata, V., Chacur, M., Schoeniger, D., Biedenkapp, J., O'Connor, K. A., Verge, G. M., Chapman, G., Green, P., Foster, A. C., Naeve, G. S., Maier, S. F., Watkins, L. R.

“…Recent evidence suggests that spinal cord glia can contribute to enhanced nociceptive responses. However, the signals that cause glial activation are unknown…”
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Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin by Gage, Brian F, Eby, Charles, Milligan, Paul E, Banet, Gerald A, Duncan, Jill R, McLeod, Howard L

“…Knowledge of pharmacogenetics may help clinicians predict their patients' therapeutic dose of warfarin, thereby decreasing the risk of bleeding during warfarin…”
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Genetic-based dosing in orthopedic patients beginning warfarin therapy by Millican, Eric A., Lenzini, Petra A., Milligan, Paul E., Grosso, Leonard, Eby, Charles, Deych, Elena, Grice, Gloria, Clohisy, John C., Barrack, Robert L., Burnett, R. Stephen J., Voora, Deepak, Gatchel, Susan, Tiemeier, Amy, Gage, Brian F.

“…High variability in drug response and a narrow therapeutic index complicate warfarin therapy initiation. No existing algorithm provides recommendations on…”
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Exogenous Delivery of Heat Shock Protein 70 Increases Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis by Gifondorwa, David J, Robinson, Mac B, Hayes, Crystal D, Taylor, Anna R, Prevette, David M, Oppenheim, Ronald W, Caress, James, Milligan, Carolanne E

“…Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder that results in the progressive loss of motoneurons (MNs) in the CNS. Several…”
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Does Age, Residency, or Feeding Guild Coupled with a Drought Index Predict Avian Health during Fall Migration? by Stanek, Jenna E, Thompson, Brent E, Milligan, Sarah E, Tranquillo, Keegan A, Fettig, Stephen M, Hathcock, Charles D

“…Birds are good indicators of environmental change and are often studied for responses to climate. Many studies focus on breeding birds, while fewer look at the…”
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Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy by Sloane, Evan, Ledeboer, A, Seibert, W, Coats, B, van Strien, M, Maier, S.F, Johnson, K.W, Chavez, R, Watkins, L.R, Leinwand, L, Milligan, E.D, Van Dam, A.M

“…Abstract Multiple Sclerosis (MS) is an autoimmune inflammatory disease that presents clinically with a range of symptoms including motor, sensory, and…”
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A Polymorphism in the VKORC1 Regulator Calumenin Predicts Higher Warfarin Dose Requirements in African Americans by Voora, D, Koboldt, D C, King, C R, Lenzini, P A, Eby, C S, Porche‐Sorbet, R, Deych, E, Crankshaw, M, Milligan, P E, McLeod, H L, Patel, S R, Cavallari, L H, Ridker, P M, Grice, G R, Miller, R D, Gage, B F

“…Warfarin demonstrates a wide interindividual variability in response that is mediated partly by variants in cytochrome P450 2C9 (CYP2C9) and vitamin K…”
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Analysis and design of membrane structures: Results of a round robin exercise by Gosling, P.D., Bridgens, B.N., Albrecht, A., Alpermann, H., Angeleri, A., Barnes, M., Bartle, N., Canobbio, R., Dieringer, F., Gellin, S., Lewis, W.J., Mageau, N., Mahadevan, R., Marion, J.-M., Marsden, P., Milligan, E., Phang, Y.P., Sahlin, K., Stimpfle, B., Suire, O., Uhlemann, J.

“…[Display omitted] ► Twenty two participants have analysed four precisely defined tensile membrane structures. ► Results show high levels of variability of…”
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Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype by Voora, Deepak, Eby, Charles, Linder, Mark W, Milligan, Paul E, Bukaveckas, Bonny L, McLeod, Howard L, Maloney, William, Clohisy, John, Burnett, R Steven, Grosso, Leonard, Gatchel, Susan K, Gage, Brian F

“…Cytochrome P-450 2C9 (CYP2C9) polymorphisms (CYP2C9*2 and CYP2C9*3) reduce the clearance of warfarin, increase the risk of bleeding, and prolong the time to…”
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Extracellular Heat Shock Protein 70: A Critical Component for Motoneuron Survival by Robinson, Mac B, Tidwell, J. Lille, Gould, Thomas, Taylor, Anna R, Newbern, Jason M, Graves, Jason, Tytell, Michael, Milligan, Carol E

“…The dependence of developing spinal motoneuron survival on a soluble factor(s) from their target, muscle tissue is well established both in vivo and in vitro…”
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A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis by Markert, Chad D, Kim, Eunkuk, Gifondorwa, David J, Childers, Martin K, Milligan, Carol E

“…The underlying causes of denervation of the neuromuscular junction and eventual motor neuron death in amyotrophic lateral sclerosis (ALS) have not been…”
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