Search Results - "Millhauser, Glenn L"

Copper and the prion protein: methods, structures, function, and disease by Millhauser, Glenn L

“…The transmissible spongiform encephalopathies (TSEs) arise from conversion of the membrane-bound prion protein from PrP(C) to PrP(Sc). Examples of the TSEs…”
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Interaction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation by Evans, Eric G.B., Pushie, M. Jake, Markham, Kate A., Lee, Hsiau-Wei, Millhauser, Glenn L.

“…Copper plays a critical role in prion protein (PrP) physiology. Cu2+ binds with high affinity to the PrP N-terminal octarepeat (OR) domain, and intracellular…”
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Mechanistic Study on the Solution-Phase n‑Doping of 1,3-Dimethyl-2-aryl-2,3-dihydro‑1H‑benzoimidazole Derivatives by Naab, Benjamin D, Guo, Song, Olthof, Selina, Evans, Eric G. B, Wei, Peng, Millhauser, Glenn L, Kahn, Antoine, Barlow, Stephen, Marder, Seth R, Bao, Zhenan

“…The discovery of air-stable n-dopants for organic semiconductor materials has been hindered by the necessity of high-energy HOMOs and the air sensitivity of…”
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Photocatalytic Generation of Singlet Oxygen by Graphitic Carbon Nitride for Antibacterial Applications by DuBois, Davida Briana, Rivera, Isabelle, Liu, Qiming, Yu, Bingzhe, Singewald, Kevin, Millhauser, Glenn L, Saltikov, Chad, Chen, Shaowei

“…Carbon-based functional nanocomposites have emerged as potent antimicrobial agents and can be exploited as a viable option to overcome antibiotic resistance of…”
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The rich electrochemistry and redox reactions of the copper sites in the cellular prion protein by Zhou, Feimeng, Millhauser, Glenn L.

“…► We review the structures and electrochemical properties of PrP-copper complexes. ► Electrochemical behavior depends strongly on the copper load in the prion…”
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Testing the Conformational Hypothesis of Passive Membrane Permeability Using Synthetic Cyclic Peptide Diastereomers by Rezai, Taha, Yu, Bin, Millhauser, Glenn L, Jacobson, Matthew P, Lokey, R. Scott

“…Little is known about the effect of conformation on passive membrane diffusion rates in small molecules. Evidence suggests that intramolecular hydrogen bonding…”
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The N-terminus of the prion protein is a toxic effector regulated by the C-terminus by Wu, Bei, McDonald, Alex J, Markham, Kathleen, Rich, Celeste B, McHugh, Kyle P, Tatzelt, Jörg, Colby, David W, Millhauser, Glenn L, Harris, David A

“…PrP , the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrP , the infectious isoform, but how this occurs is mysterious…”
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Zinc Drives a Tertiary Fold in the Prion Protein with Familial Disease Mutation Sites at the Interface by Spevacek, Ann R., Evans, Eric G.B., Miller, Jillian L., Meyer, Heidi C., Pelton, Jeffrey G., Millhauser, Glenn L.

“…The cellular prion protein PrPC consists of two domains—a flexible N-terminal domain, which participates in copper and zinc regulation, and a largely helical…”
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The Affinity of Copper Binding to the Prion Protein Octarepeat Domain:  Evidence for Negative Cooperativity by Walter, Eric D, Chattopadhyay, Madhuri, Millhauser, Glenn L

“…The prion protein (PrP) binds Cu2+ in its N-terminal octarepeat domain, composed of four or more tandem PHGGGWGQ segments. Previous work from our laboratory…”
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The Prion Protein is a Combined Zinc and Copper Binding Protein:  Zn2+ Alters the Distribution of Cu2+ Coordination Modes by Walter, Eric D, Stevens, Daniel J, Visconte, Micah P, Millhauser, Glenn L

“…PrP binds copper in the highly conserved, unstructured N-terminal half of the protein. The octarepeat region consists of four tandem repeats of PHGGGWGQ and…”
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n-Dopants Based on Dimers of Benzimidazoline Radicals: Structures and Mechanism of Redox Reactions by Zhang, Siyuan, Naab, Benjamin D., Jucov, Evgheni V., Parkin, Sean, Evans, Eric G. B., Millhauser, Glenn L., Timofeeva, Tatiana V., Risko, Chad, Brédas, Jean-Luc, Bao, Zhenan, Barlow, Stephen, Marder, Seth R.

“…Dimers of 2‐substituted N,N′‐dimethylbenzimidazoline radicals, (2‐Y‐DMBI)2 (Y=cyclohexyl (Cyc), ferrocenyl (Fc), ruthenocenyl (Rc)), have recently been…”
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Pineal-specific agouti protein regulates teleost background adaptation by Zhang, Chao, Song, Youngsup, Thompson, Darren A., Madonna, Michael A., Millhauser, Glenn L., Toro, Sabrina, Varga, Zoltan, Westerfield, Monte, Gamse, Joshua, Chen, Wenbiao, Cone, Roger D.

“…Background adaptation is used by teleosts as one of a variety of camouflage mechanisms for avoidance of predation. Background adaptation is known to involve…”
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Antimicrobial activity of graphene oxide quantum dots: impacts of chemical reduction by Rojas-Andrade, Mauricio D, Nguyen, Tuan Anh, Mistler, William P, Armas, Juan, Lu, Jia En, Roseman, Graham, Hollingsworth, William R, Nichols, Forrest, Millhauser, Glenn L, Ayzner, Alexander, Saltikov, Chad, Chen, Shaowei

“…Design and engineering of graphene-based functional nanomaterials for effective antimicrobial applications has been attracting extensive interest. In the…”
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Quantification of the Binding Properties of Cu2+ to the Amyloid Beta Peptide: Coordination Spheres for Human and Rat Peptides and Implication on Cu2+-Induced Aggregation by Hong, Lian, Carducci, Tessa M, Bush, William D, Dudzik, Christopher G, Millhauser, Glenn L, Simon, John D

“…There is no consensus on the coordinating ligands for Cu2+ by Aβ. However, the differences in peptide sequence between human and rat have been hypothesized to…”
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Early onset prion disease from octarepeat expansion correlates with copper binding properties by Stevens, Daniel J, Walter, Eric D, Rodríguez, Abel, Draper, David, Davies, Paul, Brown, David R, Millhauser, Glenn L

“…Insertional mutations leading to expansion of the octarepeat domain of the prion protein (PrP) are directly linked to prion disease. While normal PrP has four…”
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Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax) by Sánchez, Elisa, Rubio, Vera Cruz, Thompson, Darren, Metz, Juriaan, Flik, Gert, Millhauser, Glenn L, Cerdá-Reverter, José Miguel

“…The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor mainly expressed in the central nervous system of vertebrates. Activation of the MC4R leads…”
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Copper Coordination in the Full-Length, Recombinant Prion Protein by Burns, Colin S, Aronoff-Spencer, Eliah, Legname, Giuseppe, Prusiner, Stanley B, Antholine, William E, Gerfen, Gary J, Peisach, Jack, Millhauser, Glenn L

“…The prion protein (PrP) binds divalent copper at physiologically relevant conditions and is believed to participate in copper regulation or act as a…”
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Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System by Nix, Matthew A., Kaelin, Christopher B., Palomino, Rafael, Miller, Jillian L., Barsh, Gregory S., Millhauser, Glenn L.

“…The β-defensins are a class of small cationic proteins that serve as components of numerous systems in vertebrate biology, including the immune and…”
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Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein by Burns, Colin S, Aronoff-Spencer, Eliah, Dunham, Christine M, Lario, Paula, Avdievich, Nikolai I, Antholine, William E, Olmstead, Marilyn M, Vrielink, Alice, Gerfen, Gary J, Peisach, Jack, Scott, William G, Millhauser, Glenn L

“…Recent evidence suggests that the prion protein (PrP) is a copper binding protein. The N-terminal region of human PrP contains four sequential copies of the…”
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Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway by Hida, Tokimasa, Wakamatsu, Kazumasa, Sviderskaya, Elena V., Donkin, Andrew J., Montoliu, Lluis, Lynn Lamoreux, M., Yu, Bin, Millhauser, Glenn L., Ito, Shosuke, Barsh, Gregory S., Jimbow, Kowichi, Bennett, Dorothy C.

“…Summary Melanocortin‐1 receptor (MC1R) and its ligands, α‐melanocyte stimulating hormone (αMSH) and agouti signaling protein (ASIP), regulate switching between…”
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