Search Results - "Millership, Steven"

Genomic imprinting and its effects on postnatal growth and adult metabolism by Millership, Steven J., Van de Pette, Mathew, Withers, Dominic J.

“…Imprinted genes display parent-of-origin-specific expression with this epigenetic system of regulation found exclusively in therian mammals. Historically,…”
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Importance of Both Imprinted Genes and Functional Heterogeneity in Pancreatic Beta Cells: Is There a Link? by Chabosseau, Pauline, Rutter, Guy A, Millership, Steven J

“…Diabetes mellitus now affects more than 400 million individuals worldwide, with significant impacts on the lives of those affected and associated…”
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Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice by Rosell, Meritxell, Kaforou, Myrsini, Frontini, Andrea, Okolo, Anthony, Chan, Yi-Wah, Nikolopoulou, Evanthia, Millership, Steven, Fenech, Matthew E, MacIntyre, David, Turner, Jeremy O, Moore, Jonathan D, Blackburn, Edith, Gullick, William J, Cinti, Saverio, Montana, Giovanni, Parker, Malcolm G, Christian, Mark

“…Brown adipocytes dissipate energy, whereas white adipocytes are an energy storage site. We explored the plasticity of different white adipose tissue depots in…”
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Imprinted Genes Impact Upon Beta Cell Function in the Current (and Potentially Next) Generation by Villanueva-Hayes, Chelsie, Millership, Steven J

“…Beta cell failure lies at the centre of the aetiology and pathogenesis of type 2 diabetes and the epigenetic control of the expression of critical beta cell…”
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β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins by Ninkina, Natalia, Millership, Steven J., Peters, Owen M., Connor-Robson, Natalie, Chaprov, Kirill, Kopylov, Arthur T., Montoya, Alex, Kramer, Holger, Withers, Dominic J., Buchman, Vladimir L.

“…Synucleins, a family of three proteins highly expressed in neurons, are predominantly known for the direct involvement of α-synuclein in the etiology and…”
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Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice by Van de Pette, Mathew, Dimond, Andrew, Galvão, António M., Millership, Steven J., To, Wilson, Prodani, Chiara, McNamara, Gráinne, Bruno, Ludovica, Sardini, Alessandro, Webster, Zoe, McGinty, James, French, Paul M. W., Uren, Anthony G., Castillo-Fernandez, Juan, Watkinson, William, Ferguson-Smith, Anne C., Merkenschlager, Matthias, John, Rosalind M., Kelsey, Gavin, Fisher, Amanda G.

“…Transmission of epigenetic information between generations occurs in nematodes, flies and plants, mediated by specialised small RNA pathways, modified histones…”
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Neuronatin regulates pancreatic β cell insulin content and secretion by Millership, Steven J, Da Silva Xavier, Gabriela, Choudhury, Agharul I, Bertazzo, Sergio, Chabosseau, Pauline, Pedroni, Silvia Ma, Irvine, Elaine E, Montoya, Alex, Faull, Peter, Taylor, William R, Kerr-Conte, Julie, Pattou, Francois, Ferrer, Jorge, Christian, Mark, John, Rosalind M, Latreille, Mathieu, Liu, Ming, Rutter, Guy A, Scott, James, Withers, Dominic J

“…Neuronatin (Nnat) is an imprinted gene implicated in human obesity and widely expressed in neuroendocrine and metabolic tissues in a hormone- and…”
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Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity by Yu, Vanessa, Yong, Fiona, Marta, Angellica, Khadayate, Sanjay, Osakwe, Adrien, Bhattacharya, Supriyo, Varghese, Sneha S., Chabosseau, Pauline, Tabibi, Sayed M., Chen, Keran, Georgiadou, Eleni, Parveen, Nazia, Suleiman, Mara, Stamoulis, Zoe, Marselli, Lorella, De Luca, Carmela, Tesi, Marta, Ostinelli, Giada, Delgadillo-Silva, Luis, Wu, Xiwei, Hatanaka, Yuki, Montoya, Alex, Elliott, James, Patel, Bhavik, Demchenko, Nikita, Whilding, Chad, Hajkova, Petra, Shliaha, Pavel, Kramer, Holger, Ali, Yusuf, Marchetti, Piero, Sladek, Robert, Dhawan, Sangeeta, Withers, Dominic J., Rutter, Guy A., Millership, Steven J.

“…Aims/hypothesis Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions…”
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Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis by Mousavy Gharavy, S. Neda, Owen, Bryn M., Millership, Steven J., Chabosseau, Pauline, Pizza, Grazia, Martinez-Sanchez, Aida, Tasoez, Emirhan, Georgiadou, Eleni, Hu, Ming, Fine, Nicholas H. F., Jacobson, David A., Dickerson, Matthew T., Idevall-Hagren, Olof, Montoya, Alex, Kramer, Holger, Mehta, Zenobia, Withers, Dominic J., Ninov, Nikolay, Gadue, Paul J., Cardenas-Diaz, Fabian L., Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Voz, Marianne, Rutter, Guy A.

“…Aims/hypothesis Variants close to the VPS13C / C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies…”
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Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice by Millership, Steven J., Tunster, Simon J., Van de Pette, Mathew, Choudhury, Agharul I., Irvine, Elaine E., Christian, Mark, Fisher, Amanda G., John, Rosalind M., Scott, James, Withers, Dominic J.

“…Imprinted genes are crucial for the growth and development of fetal and juvenile mammals. Altered imprinted gene dosage causes a variety of human disorders,…”
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Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome by Van De Pette, Matthew, Tunster, Simon J, McNamara, Grainne I, Shelkovnikova, Tatyana, Millership, Steven, Benson, Lindsay, Peirson, Stuart, Christian, Mark, Vidal-Puig, Antonio, John, Rosalind M

“…The accurate diagnosis and clinical management of the growth restriction disorder Silver Russell Syndrome (SRS) has confounded researchers and clinicians for…”
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Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity by Rached, Marie-Therese, Millership, Steven J., Pedroni, Silvia M.A., Choudhury, Agharul I., Costa, Ana S.H., Hardy, Darran G., Glegola, Justyna A., Irvine, Elaine E., Selman, Colin, Woodberry, Megan C., Yadav, Vijay K., Khadayate, Sanjay, Vidal-Puig, Antonio, Virtue, Samuel, Frezza, Christian, Withers, Dominic J.

“…Sympathetic nervous system and immune cell interactions play key roles in the regulation of metabolism. For example, recent convergent studies have shown that…”
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Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis by Peters, Owen M, Millership, Steven, Shelkovnikova, Tatyana A, Soto, Ileana, Keeling, Lora, Hann, Anthony, Marsh-Armstrong, Nicholas, Buchman, Vladimir L, Ninkina, Natalia

“…Abstract Amyotrophic lateral sclerosis (ALS) is characterised by substantial loss of both upper and lower motor neuron function, with sensory and cognitive…”
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Increased lipolysis and altered lipid homeostasis protect γ-synuclein-null mutant mice from diet-induced obesity by Millership, Steven, Ninkina, Natalia, Guschina, Irina A., Norton, Jessica, Brambilla, Ricardo, Oort, Pieter J., Adams, Sean H., Dennis, Rowena J., Voshol, Peter J., Rochford, Justin J., Buchman, Vladimir L.

“…Synucleins are a family of homologous proteins principally known for their involvement in neurodegeneration. γ-Synuclein is highly expressed in human white…”
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Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism by Connor-Robson, Natalie, Peters, Owen M, Millership, Steven, Ninkina, Natalia, Buchman, Vladimir L

“…Abstract Synucleins are involved in multiple steps of the neurotransmitter turnover but the largely normal synaptic function in young adult animals completely…”
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A link between FTO, ghrelin, and impaired brain food-cue responsivity by Karra, Efthimia, O'Daly, Owen G, Choudhury, Agharul I, Yousseif, Ahmed, Millership, Steven, Neary, Marianne T, Scott, William R, Chandarana, Keval, Manning, Sean, Hess, Martin E, Iwakura, Hiroshi, Akamizu, Takashi, Millet, Queensta, Gelegen, Cigdem, Drew, Megan E, Rahman, Sofia, Emmanuel, Julian J, Williams, Steven C R, Rüther, Ulrich U, Brüning, Jens C, Withers, Dominic J, Zelaya, Fernando O, Batterham, Rachel L

“…Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with human obesity and obesity-prone behaviors, including increased food intake…”
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Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family by Anwar, Sabina, Peters, Owen, Millership, Steven, Ninkina, Natalia, Doig, Natalie, Connor-Robson, Natalie, Threlfell, Sarah, Kooner, Gurdeep, Deacon, Robert M, Bannerman, David M, Bolam, J Paul, Chandra, Sreeganga S, Cragg, Stephanie J, Wade-Martins, Richard, Buchman, Vladimir L

“…The synucleins (α, β, and γ) are highly homologous proteins thought to play a role in regulating neurotransmission and are found abundantly in presynaptic…”
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γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein by Ninkina, Natalia, Peters, Owen, Millership, Steven, Salem, Hatem, van der Putten, Herman, Buchman, Vladimir L.

“…The role of α-synuclein in pathogenesis of familial and idiopathic forms of Parkinson’s disease, and other human disorders known as α-synucleinopathies, is…”
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Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice by Al-Wandi, Abdelmojib, Ninkina, Natalia, Millership, Steven, Williamson, Sally J.M, Jones, Paul A, Buchman, Vladimir L

“…Abstract Despite numerous evidences for neurotoxicity of overexpressed α-synuclein, a protective function was suggested for endogenous α-synuclein and other…”
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Neuronatin regulates pancreatic [beta] cell insulin content and secretion by Millership, Steven J, Xavier, Gabriela Da Silva, Choudhury, Agharul I, Bertazzo, Sergio, Chabosseau, Pauline, Pedroni, Silvia M.A, Irvine, Elaine E, Montoya, Alex, Faull, Peter, Taylor, William R, Kerr-Conte, Julie, Pattou, Francois, Ferrer, Jorge, Christian, Mark, John, Rosalind M, Latreille, Mathieu, Liu, Ming, Rutter, Guy A, Scott, James, Withers, Dominic J

“…Neuronatin (Nnat) is an imprinted gene implicated in human obesity and widely expressed in neuroendocrine and metabolic tissues in a hormone- and…”
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