Search Results - "Millership, Jeff S."
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Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine
Published in British journal of clinical pharmacology (01-10-2008)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • 6‐Mercaptopurine (6‐MP) and azathioprine (AZA) are both inactive prodrugs that require intracellular activation into…”
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Adherence to antiepileptic medicines in children: A multiple‐methods assessment involving dried blood spot sampling
Published in Epilepsia (Copenhagen) (01-06-2013)“…Summary Purpose To evaluate adherence to prescribed antiepileptic drugs (AEDs) in children with epilepsy using a combination of adherence‐assessment methods…”
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Microassay of drugs and modern measurement techniques
Published in Pediatric anesthesia (01-03-2011)“…Summary Details of the development of conventional analytical methods for the determination of drugs in pediatric plasma/serum samples via microassays are…”
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Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells
Published in Journal of pharmaceutical and biomedical analysis (20-02-2009)“…An HPLC method has been developed and validated for the rapid determination of mercaptopurine and four of its metabolites; thioguanine, thiouric acid,…”
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Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant
Published in British journal of clinical pharmacology (01-09-2009)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Currently tacrolimus is the mainstay of immunosuppression for most children undergoing liver transplantation (LT). •…”
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A sensitive gas chromatographic/mass spectrometric method for the resolution and quantification of ethosuximide enantiomers in biological fluids
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (05-06-2002)“…A modified specific, sensitive and reproducible chiral gas chromatographic (GC) method for the resolution and quantification of ethosuximide enantiomers in…”
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Population pharmacokinetic and pharmacogenetic analysis of 6‐mercaptopurine in paediatric patients with acute lymphoblastic leukaemia
Published in British journal of clinical pharmacology (01-12-2008)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The cytotoxic effects of 6‐mercaptopurine (6‐MP) were found to be due to drug‐derived intracellular metabolites…”
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development of an objective methodology to measure medication adherence to oral thiopurines in paediatric patients with acute lymphoblastic leukaemia—an exploratory study
Published in European journal of clinical pharmacology (01-11-2009)“…Aims To develop a method that prospectively assesses adherence rates in paediatric patients with acute lymphoblastic leukaemia (ALL) who are receiving the oral…”
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Facile Syntheses of the Three Major Metabolites of Thioridazine
Published in Helvetica chimica acta (01-05-2005)“…Efficient, mild syntheses of the three major metabolites 2–4 of the important antipsychotic drug thioridazine (1) have been developed. The cardiotoxic…”
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Diastereotopic analysis of mesoridazine besylate (serentil)
Published in Chirality (New York, N.Y.) (2004)“…NMR studies were conducted with the aim of determining the diastereoisomeric ratio of a commercially supplied sample of mesoridazine (MES) and to compare the…”
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