Search Results - "Miller, WH"

Role of the histone deacetylase complex in acute promyelocytic leukaemia by Evans, Ronald M, Lin, Richard J, Nagy, Laszlo, Inoue, Satoshi, Shao, Wenlin, Miller, Wilson H

“…Non-liganded retinoic acid receptors (RARs) repress transcription of target genes by recruiting the histone deacetylase complex through a class of silencing…”
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Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo by FAZI, Francesco, TRAVAGLINI, Lorena, NERVI, Clara, CAROTTI, Daniela, PALITTI, Franco, DIVERIO, Daniela, ALCALAY, Myriam, MCNAMARA, Suzan, MILLER, Wilson H, LO COCO, Francesco, GIUSEPPE PELICCI, Pier

“…The acute promyelocytic leukemia (PML)-retinoic acid receptor alpha (RARalpha) fusion product recruits histone deacetylase (HDAC) and DNA methyltransferase…”
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The Pharmacokinetics and Pharmacodynamics of Zoledronic Acid in Cancer Patients with Varying Degrees of Renal Function by Skerjanec, Andrej, Berenson, James, Hsu, ChyiHung, Major, Pierre, Miller Jr, Wilson H., Ravera, Christina, Schran, Horst, Seaman, John, Waldmeier, Felix

“…An open‐label pharmacokinetic and pharmacodynamic study of zoledronic acid (Zometaθ) was performed in 19 cancer patients with bone metastases and known,…”
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Nuclear insulin receptor substrate 1 interacts with estrogen receptor α at ERE promoters by MORELLI, Catia, GAROFALO, Cecilia, SISCI, Diego, DEL RINCON, Sonia, CASCIO, Sandra, XIAO TU, VECCHIONE, Andrea, SAUTER, Edward R, MILLER, Wilson H, SURMACZ, Eva

“…Insulin receptor substrate 1 (IRS-1) is a major signaling molecule activated by the insulin and insulin-like growth factor I receptors. Recent data obtained in…”
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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein by Dyck, J A, Maul, G G, Miller, Jr, W H, Chen, J D, Kakizuka, A, Evans, R M

“…Acute promyelocytic leukemia (APL) is associated with a t(15;17) translocation that creates the promyelocyte-retinoic acid receptor alpha (PML-RAR alpha)…”
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Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism by DEL RINCON, Sonia V, QI GUO, MORELLI, Catia, SHIU, Hoi-Ying, SURMACZ, Eva, MILLER, Wilson H

“…Insulin receptor substrate-1 (IRS-1) mediates signaling from the insulin-like growth factor type-I receptor. We found that all-trans retinoic acid (RA)…”
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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML by Kakizuka, A, Miller, Jr, W H, Umesono, K, Warrell, Jr, R P, Frankel, S R, Murty, V V, Dmitrovsky, E, Evans, R M

“…A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor…”
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Enhanced retinoid-induced apoptosis of MDA-MB-231 breast cancer cells by PKC inhibitors involves activation of ERK by PETTERSSON, Filippa, COUTURE, Marie-Claude, HANNA, Nessrine, MILLER, Wilson H

“…Retinoids are vitamin A derivatives, which cause growth inhibition, differentiation and/or apoptosis in various cell types, including some breast cancer cells…”
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Early Mortality and the Retinoic Acid Syndrome in Acute Promyelocytic Leukemia: Impact of Leukocytosis, Low-Dose Chemotherapy, PMN/RAR-α Isoform, and CD13 Expression in Patients Treated With All-Trans Retinoic Acid by Vahdat, Linda, Maslak, Peter, Miller, Wilson H., Eardley, Anna, Heller, Glenn, Scheinberg, David A., Warrell, Raymond P.

“…All-trans retinoic acid (RA) has proven a major advance in the treatment of acute promyelocytic leukemia (APL). However, the proper management of patients who…”
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The PML/RARα Oncoprotein Is a Direct Molecular Target of Retinoic Acid in Acute Promyelocytic Leukemia Cells by Raelson, John V., Nervi, Clara, Rosenauer, Angelika, Benedetti, Laura, Monczak, Yury, Pearson, Mark, Pelicci, Pier Giuseppe, Miller, Wilson H.

“…Acute promyelocytic leukemia (APL) is characterized by the translocation, t(15;17) and the expression of a PML/RARα fusion protein that is diagnostic of the…”
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Differentiation induction as a treatment for hematologic malignancies by Miller, WH Jr, Waxman, S

“…In many acute leukemias and some lymphomas, aberrant differentiation is a major feature of the malignant phenotype that often results from a single genetic…”
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Loss of retinoic acid receptor β gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines by SUH, Young-Ah, LEE, Ho-Young, VIRMANI, Arvind, JIEMIN WONG, MANN, Koren K, MILLER, Wilson H, GAZDAR, Adi, KURIE, Jonathan M

“…Most lung cancer cell lines do not express retinoic acid receptor (RAR)-beta in response to all-trans retinoic acid (RA) because of a defect in RARbeta gene…”
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Retinoic acid-induced growth arrest of MCF-7 cells involves the selective regulation of the IRS-1 PI 3-kinase AKT pathway by DEL RINCON, Sonia V, ROUSSEAU, Caroline, SAMANTA, Ratna, MILLER, Wilson H

“…In the MCF-7 breast cancer cell line, insulin-like growth factors (IGFs) are known to elicit antiproliferative actions via the insulin receptor substrate-1…”
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Clinical and Molecular Characterization of a Rare Syndrome of Acute Promyelocytic Leukemia Associated With Translocation (11; 17) by Licht, Jonathan D., Chomienne, Christine, Goy, Andre, Chen, Alex, Scott, Amy A., Head, David R., Michaux, Jean Louis, Wu, Yu, DeBlasio, Anthony, Miller, Wilson H., Zelenetz, Andrew D., Willman, Cheryl L., Chen, Zhu, Chen, Sai-Juan, Zelent, A., Macintyre, Elizabeth, Veil, Agnes, Cortes, Jorge, Kantarjian, Hagop, Waxman, Samuel

“…Analysis of a variant translocation t(11; 17) in a case of acute promyelocytic leukemia (APL) led to discovery of a novel zinc finger gene, PLZF, fused to the…”
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Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations : implications for relapse and retinoid resistance in patients with acute promyelocytic leukemia by MUINDI, J, FRANKEL, S. R, MILLER, W. H, JAKUBOWSKI, A, SCHEINBERG, D. A, YOUNG, C. W, DMITROVSKY, E, WARRELL, R. P

“…Although all-trans retinoic acid (RA) induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL), all groups have…”
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Sensitive nested reverse transcription polymerase chain reaction detection of circulating prostatic tumor cells: comparison of prostate-specific membrane antigen and prostate-specific antigen-based assays by ISRAELI, R. S, MILLER, W. H, HESTON, W. D. W, SU, S. L, POWELL, C. T, FAIR, W. R, SAMADI, D. S, HURYK, R. F, DEBLASIO, A, EDWARDS, E. T, WISE, G. J

“…A highly sensitive nested reverse transcriptase-PCR assay, with primers derived from the prostate-specific antigen (PSA) and prostate-specific membrane antigen…”
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The N-terminal of the estrogen receptor (ERα) mediates transcriptional cross-talk with the retinoic acid receptor in human breast cancer cells by Rousseau, Caroline, Pettersson, Filippa, Couture, Marie-Claude, Paquin, Andre, Galipeau, Jacques, Mader, Sylvie, Miller, Wilson H.

“…Transcriptional cross-talk exists between the estrogen receptor (ERα) and retinoic acid receptor (RAR) pathways in human breast cancer cells. We have…”
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Reverse Transcription Polymerase Chain Reaction for the Rearranged Retinoic Acid Receptor α Clarifies Diagnosis and Detects Minimal Residual Disease in Acute Promyelocytic Leukemia by Miller, Wilson H., Kakizuka, Akira, Frankel, Stanley R., Warrell, Raymond P., DeBlasio, Anthony, Levine, Kristi, Evans, Ronald M., Dmitrovsky, Ethan

“…The characteristic t(15;17) of acute promyelocytic leukemia (APL) fuses the retinoic acid receptor α (RAR-α) gene on chromosome 17 to a gene on chromosome 15…”
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The Semiclassical Initial Value Representation:  A Potentially Practical Way for Adding Quantum Effects to Classical Molecular Dynamics Simulations by Miller, William H.

“…The semiclassical (SC) initial value representation (IVR) provides a potentially practical way for adding quantum mechanical effects to classical molecular…”
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Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wild-type retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines by ROSENAUER, A, RAELSON, J. V, NERVI, C, EYDOUX, P, DEBLASIO, A, MILLER, W. H

“…All-trans retinoic acid (tRA), a naturally occurring ligand of the nuclear retinoic acid receptors (RARs), induces differentiation of leukemic cells and…”
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