Search Results - "Miller, Sam R"

Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study by Hegade, Vinod S, Dr, Kendrick, Stuart F W, PhD, Dobbins, Robert L, MD, Miller, Sam R, MSc, Thompson, Douglas, PhD, Richards, Duncan, FRCP, Storey, James, PhD, Dukes, George E, PharmD, Corrigan, Margaret, MRCP, Oude Elferink, Ronald P J, PhD, Beuers, Ulrich, Prof, Hirschfield, Gideon M, Prof, Jones, David E, Prof

“…Summary Background Up to 70% of patients with primary biliary cholangitis develop pruritus (itch) during the course of their disease. Treatment of pruritus in…”
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Within-subject comparison of [ C]-(+)-PHNO and [ C]raclopride sensitivity to acute amphetamine challenge in healthy humans by Shotbolt, Paul, Tziortzi, Andri C, Searle, Graham E, Colasanti, Alessandro, van der Aart, Jasper, Abanades, Sergio, Plisson, Christophe, Miller, Sam R, Huiban, Mickael, Beaver, John D, Gunn, Roger N, Laruelle, Marc, Rabiner, Eugenii A

“…[11C]PHNO is a D2/D3 agonist positron emission tomography radiotracer, with higher in vivo affinity for D3 than for D2 receptors. As [11C]-( + )-PHNO is an…”
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Assessment of plasma acylcarnitines before and after weight loss in obese subjects by Schooneman, Marieke G., Napolitano, Antonella, Houten, Sander M., Ambler, Graeme K., Murgatroyd, Peter R., Miller, Sam R., Hollak, Carla E.M., Tan, Chong Y., Virtue, Samuel, Vidal-Puig, Antonio, Nunez, Derek J., Soeters, Maarten R.

“…Acylcarnitines, fatty acid oxidation (FAO) intermediates, have been implicated in diet-induced insulin resistance and type 2 diabetes mellitus, as increased…”
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Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI by TANG, Tjun, HOWARTH, Simon P. S, GILLARD, Jonathan H, MILLER, Sam R, TRIVEDI, Rikin, GRAVES, Martin J, KING-IM, Jean U, LI, Zhi Y, BROWN, Andrew P, KIRKPATRICK, Peter J, GAUNT, Michael E

“…It is well known that the vulnerable atheromatous plaque has a thin, fibrous cap and large lipid core with associated inflammation. This inflammation can be…”
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T1-weighted sodium MRI of the articulator cartilage in osteoarthritis: a cross sectional and longitudinal study by Newbould, Rexford D, Miller, Sam R, Upadhyay, Neil, Rao, Anil W, Swann, Peter, Gold, Garry E, Strachan, Robin K, Matthews, Paul M, Taylor, Peter C, Brown, Andrew P

“…Structural magnetic resonance imaging (MRI) has shown great utility in diagnosing soft tissue burden in osteoarthritis (OA), though MRI measures of cartilage…”
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Cross-Modal Associations in Synaesthesia: Vowel Colours in the Ear of the Beholder by Moos, Anja, Smith, Rachel, Miller, Sam R., Simmons, David R.

“…Human speech conveys many forms of information, but for some exceptional individuals (synaesthetes), listening to speech sounds can automatically induce visual…”
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Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functional BDNF Val66Met polymorphism by Soltész, Fruzsina, Suckling, John, Lawrence, Phil, Tait, Roger, Ooi, Cinly, Bentley, Graham, Dodds, Chris M, Miller, Sam R, Wille, David R, Byrne, Misha, McHugh, Simon M, Bellgrove, Mark A, Croft, Rodney J, Lu, Bai, Bullmore, Edward T, Nathan, Pradeep J

“…Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor…”
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Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks by Dodds, Chris M, Henson, Richard N, Suckling, John, Miskowiak, Kamilla W, Ooi, Cinly, Tait, Roger, Soltesz, Fruzsina, Lawrence, Phil, Bentley, Graham, Maltby, Kay, Skeggs, Andrew, Miller, Sam R, McHugh, Simon, Bullmore, Edward T, Nathan, Pradeep J

“…It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI…”
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The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study: Evaluation Using Ultrasmall Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging in Carotid Disease by TANG, Tjun Y, HOWARTH, Simon P. S, WARBURTON, Elizabeth A, HAYES, Paul D, VARTY, Kevin, BOYLE, Jonathan R, GAUNT, Michael E, ZALEWSKI, Andrew, GILLARD, Jonathan H, MILLER, Sam R, GRAVES, Martin J, PATTERSON, Andrew J, U-KING-IM, Jean-Marie, LI, Zhi Y, WALSH, Stewart R, BROWN, Andrew P, KIRKPATRICK, Peter J

“…The aim of this study was to evaluate the effects of low-dose (10 mg) and high-dose (80 mg) atorvastatin on carotid plaque inflammation as determined by…”
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Direct visualisation of collateral ventilation in COPD with hyperpolarised gas MRI by Marshall, Helen, Deppe, Martin H, Parra-Robles, Juan, Hillis, Susan, Billings, Catherine G, Rajaram, Smitha, Swift, Andrew, Miller, Sam R, Watson, Joanna H, Wolber, Jan, Lipson, David A, Lawson, Rod, Wild, Jim M

“…Collateral ventilation has been proposed as a mechanism of compensation of respiratory function in obstructive lung diseases but observations of it in vivo are…”
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The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial by Boyle, Yvonne, Fernando, Disala, Kurz, Hazel, Miller, Sam R., Zucchetto, Mauro, Storey, James

“…The combination of gabapentin plus donepezil reduced the area of hyperalgesia and allodynia vs gabapentin alone in an experimental pain model in healthy…”
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The effects of GSK2981710, a medium‐chain triglyceride, on cognitive function in healthy older participants: A randomised, placebo‐controlled study by O'Neill, Barry V., Dodds, Chris M., Miller, Sam R., Gupta, Ashutosh, Lawrence, Philip, Bullman, Jonathan, Chen, Chao, Dewit, Odile, Kumar, Subramanya, Dustagheer, Mushi, Price, Jeffrey, Shabbir, Shaila, Nathan, Pradeep J.

“…Objective This double‐blind, randomised, placebo‐controlled, two‐part study assessed the impact of GSK2981710, a medium‐chain triglyceride (MCT) that liberates…”
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Structural neuroimaging correlates of allelic variation of the BDNF val66met polymorphism by Forde, Natalie J., Ronan, Lisa, Suckling, John, Scanlon, Cathy, Neary, Simon, Holleran, Laurena, Leemans, Alexander, Tait, Roger, Rua, Catarina, Fletcher, Paul C., Jeurissen, Ben, Dodds, Chris M., Miller, Sam R., Bullmore, Edward T., McDonald, Colm, Nathan, Pradeep J., Cannon, Dara M.

“…The brain-derived neurotrophic factor (BDNF) val66met polymorphism is associated with altered activity dependent secretion of BDNF and a variable influence on…”
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The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice by Ripley, Tamzin L., Sanchez-Roige, Sandra, Bullmore, Edward T., Mugnaini, Manolo, Maltby, Kay, Miller, Sam R., Wille, David R., Nathan, Pradeep, Stephens, David N.

“…Rationale Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed…”
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T2 measurement of the knee articular cartilage in osteoarthritis at 3T by Newbould, Rexford D., Miller, Sam R., Toms, Laurence D., Swann, Peter, Tielbeek, Jeroen A.W., Gold, Garry E., Strachan, Robin K., Taylor, Peter C., Matthews, Paul M., Brown, Andrew P.

“…Purpose: To measure reproducibility, longitudinal and cross‐sectional differences in T2* maps at 3 Tesla (T) in the articular cartilage of the knee in subjects…”
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The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study by Tang, Tjun Y., MB, BChir, Howarth, Simon P.S., BMBCh (Oxon), Miller, Sam R., MSc, Graves, Martin J., MSc, Patterson, Andrew J., PhD, U-King-Im, Jean-Marie, PhD, Li, Zhi Y., PhD, Walsh, Stewart R., MSc, Brown, Andrew P., BSc, Kirkpatrick, Peter J., FmedSci, Warburton, Elizabeth A., DM, Hayes, Paul D., MD, Varty, Kevin, MD, Boyle, Jonathan R., MD, Gaunt, Michael E., MD, Zalewski, Andrew, PhD, Gillard, Jonathan H., MD

“…Objectives The aim of this study was to evaluate the effects of low-dose (10 mg) and high-dose (80 mg) atorvastatin on carotid plaque inflammation as…”
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Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum by Fletcher, Paul C, Napolitano, Antonella, Skeggs, Andrew, Miller, Sam R, Delafont, Bruno, Cambridge, Victoria C, de Wit, Sanne, Nathan, Pradeep J, Brooke, Allison, O'Rahilly, Stephen, Farooqi, I Sadaf, Bullmore, Edward T

“…We used functional magnetic resonance imaging to explore brain responses to food images in overweight humans, examining independently the impact of a prescan…”
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Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Vasist Johnson, Lakshmi, Fletcher, Paul C, Bullmore, Edward T

“…The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The…”
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BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial by Hegade, Vinod S, Kendrick, Stuart F W, Dobbins, Robert L, Miller, Sam R, Richards, Duncan, Storey, James, Dukes, George, Gilchrist, Kim, Vallow, Susan, Alexander, Graeme J, Corrigan, Margaret, Hirschfield, Gideon M, Jones, David E J

“…Pruritus (itch) is a symptom commonly experienced by patients with cholestatic liver diseases such as primary biliary cholangitis (PBC, previously referred to…”
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Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype by Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Johnson, Lakshmi Vasist, Fletcher, Paul C, Bullmore, Edward T

“…This corrects the article DOI: 10.1038/npp.2016.60…”
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