Search Results - "Miller, Miles C"

Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier by Osgood, Doreen, PhD, Miller, Miles C., MSc, Messier, Arthur A., PhD, Gonzalez, Liliana, PhD, Silverberg, Gerald D., MD

“…Abstract Decreased clearance of potentially toxic metabolites, due to aging changes, likely plays a significant role in the accumulation of amyloid-beta…”
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P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations by Chiu, Catherine, Miller, Miles C, Monahan, Renée, Osgood, Doreen P, Stopa, Edward G, Silverberg, Gerald D

“…Abstract P-glycoprotein (P-gp), part of the blood-brain barrier, limits drug access to the brain and is the target for therapies designed to improve drug…”
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Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis by Stopa, Edward G, Tanis, Keith Q, Miller, Miles C, Nikonova, Elena V, Podtelezhnikov, Alexei A, Finney, Eva M, Stone, David J, Camargo, Luiz M, Parker, Lisan, Verma, Ajay, Baird, Andrew, Donahue, John E, Torabi, Tara, Eliceiri, Brian P, Silverberg, Gerald D, Johanson, Conrad E

“…In Alzheimer's disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression…”
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Ontogeny of inter‐alpha inhibitor protein (IAIP) expression in human brain by Kim, Boram, De La Monte, Suzanne, Hovanesian, Virginia, Patra, Aparna, Chen, Xiaodi, Chen, Ray H., Miller, Miles C., Pinar, Mehmet Halit, Lim, Yow‐Pin, Stopa, Edward G., Stonestreet, Barbara S.

“…Inter‐alpha inhibitor proteins (IAIPs) are naturally occurring immunomodulatory molecules found in most tissues. We have reported ontogenic changes in the…”
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RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease by Donahue, John E, Flaherty, Stephanie L, Johanson, Conrad E, Duncan, 3rd, John A, Silverberg, Gerald D, Miller, Miles C, Tavares, Rosemarie, Yang, Wentian, Wu, Qian, Sabo, Edmond, Hovanesian, Virginia, Stopa, Edward G

“…The receptor for advanced glycation end products (RAGE) is thought to be a primary transporter of beta-amyloid across the blood-brain barrier (BBB) into the…”
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Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent by Pascale, Crissey L, Miller, Miles C, Chiu, Catherine, Boylan, Matthew, Caralopoulos, Ilias N, Gonzalez, Liliana, Johanson, Conrad E, Silverberg, Gerald D

“…Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's disease (AD). There is an accumulation of amyloid-beta peptides (Aβ) in…”
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Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months by Chiu, Catherine, Miller, Miles C, Caralopoulos, Ilias N, Worden, Michael S, Brinker, Thomas, Gordon, Zachary N, Johanson, Conrad E, Silverberg, Gerald D

“…Amyloid accumulation in the brain parenchyma is a hallmark of Alzheimer's disease (AD) and is seen in normal aging. Alterations in cerebrospinal fluid (CSF)…”
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Amyloid Deposition and Influx Transporter Expression at the Blood-Brain Barrier Increase in Normal Aging by Silverberg, Gerald D, Miller, Miles C, Messier, Arthur A, Majmudar, Samir, Machan, Jason T, Donahue, John E, Stopa, Edward G, Johanson, Conrad E

“…Aging is the most important single risk factor for developing Alzheimer disease. We measured amyloid-β peptide (Aβ) levels in rat cerebral cortex and…”
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Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury by Podvin, Sonia, Gonzalez, Ana-Maria, Miller, Miles C, Dang, Xitong, Botfield, Hannah, Donahue, John E, Kurabi, Arwa, Boissaud-Cooke, Matthew, Rossi, Ryan, Leadbeater, Wendy E, Johanson, Conrad E, Coimbra, Raul, Stopa, Edward G, Eliceiri, Brian P, Baird, Andrew

“…By virtue of its ability to regulate the composition of cerebrospinal fluid (CSF), the choroid plexus (CP) is ideally suited to instigate a rapid response to…”
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Amyloid Efflux Transporter Expression at the Blood-Brain Barrier Declines in Normal Aging by SILVERBERG, Gerald D, MESSIER, Arthur A, MILLER, Miles C, MACHAN, Jason T, MAJMUDAR, Samir S, STOPA, Edward G, DONAHUE, John E, JOHANSON, Conrad E

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Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury by Gonzalez, Ana Maria, Podvin, Sonia, Lin, Shuh-Yow, Miller, Miles C, Botfield, Hannah, Leadbeater, Wendy E, Roberton, Andrew, Dang, Xitong, Knowling, Stuart E, Cardenas-Galindo, Elena, Donahue, John E, Stopa, Edward G, Johanson, Conrad E, Coimbra, Raul, Eliceiri, Brian P, Baird, Andrew

“…The content and composition of cerebrospinal fluid (CSF) is determined in large part by the choroid plexus (CP) and specifically, a specialized epithelial cell…”
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The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation by Benallegue, Nail, Kebir, Hania, Kapoor, Richa, Crockett, Alexis, Li, Cen, Cheslow, Lara, Abdel-Hakeem, Mohamed S, Gesualdi, James, Miller, Miles C, Wherry, E John, Church, Molly E, Blanco, M Andres, Alvarez, Jorge I

“…The concerted actions of the CNS and the immune system are essential to coordinating the outcome of neuroinflammatory responses. Yet, the precise mechanisms…”
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Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis by Church, Molly E, Ceja, Guadalupe, McGeehan, Megan, Miller, Miles C, Farias, Priscilla, Sánchez, Melissa D, Swain, Gary P, Assenmacher, Charles-Antoine, Stopa, Edward G, Vite, Charles H, Bar-Or, Amit, Alvarez, Jorge I

“…Multiple sclerosis (MS) is an idiopathic demyelinating disease in which meningeal inflammation correlates with accelerated disease progression. The study of…”
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Therapeutic concentrations of glucagon-like peptide-1 in cerebrospinal fluid following cell-based delivery into the cerebral ventricles of cats by Glage, Silke, Klinge, Petra M, Miller, Miles C, Wallrapp, Christine, Geigle, Peter, Hedrich, Hans J, Brinker, Thomas

“…Neuropeptides may have considerable potential in the treatment of acute and chronic neurological diseases. Encapsulated genetically engineered cells have been…”
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Amyloid Efflux Transporter Expression at the Blood-Brain Barrier Declines in Normal Aging by Silverberg, Gerald D, Messier, Arthur A, Miller, Miles C, Machan, Jason T, Majmudar, Samir S, Stopa, Edward G, Donahue, John E, Johanson, Conrad E

“…Reduced clearance of amyloid β peptides (Aβ) across the blood-brain barrier contributes to amyloid accumulation in Alzheimer disease. Amyloid β efflux…”
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Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease by Miller, Miles C, Tavares, Rosemarie, Johanson, Conrad E, Hovanesian, Virginia, Donahue, John E, Gonzalez, Liliana, Silverberg, Gerald D, Stopa, Edward G

“…Abstract Microvascular accumulation and neuronal overproduction of amyloid-β peptide (Aβ) are pathologic features of Alzheimer's disease (AD). In this study,…”
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Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer's disease by Klinge, Petra M., Harmening, Kathrin, Miller, Miles C., Heile, Anna, Wallrapp, Christine, Geigle, Peter, Brinker, Thomas

“…► Cerebral transplantation of mesenchymal stem cell (MSC) in mice model of Alzheimers disease. ► Comparison of encapsulated native and glucagon-like peptide-1…”
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Changes in Brain β-Amyloid Deposition and Aquaporin 4 Levels in Response to Altered Agrin Expression in Mice by Rauch, Steven M, Huen, Kathy, Miller, Miles C, Chaudry, Hira, Lau, Melissa, Sanes, Joshua R, Johanson, Conrad E, Stopa, Edward G, Burgess, Robert W

“…ABSTRACTConditions that compromise the blood-brain barrier (BBB) have been increasingly implicated in the pathogenesis of Alzheimer disease (AD). AGRIN is a…”
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Amyloid-Beta Accumulation, Neurogenesis, Behavior, and the Age of Rats by Church, Russell M, Miller, Miles C, Freestone, David, Chiu, Catharine, Osgood, Doreen P, Machan, Jason T, Messier, Arthur A, Johanson, Conrad E, Silverberg, Gerald D

“…The goals of this research were to describe age-related changes in brain biochemistry and behavior, and the relationships between them. The chronological ages…”
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Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP by Silverberg, Gerald D, Miller, Miles C, Pascale, Crissey L, Caralopoulos, Ilias N, Agca, Yuksel, Agca, Cansu, Stopa, Edward G

“…Normal pressure hydrocephalus (NPH) is most common in the elderly and has a high co-morbidity with Alzheimer's disease (AD) and cerebrovascular disease (CVD)…”
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